Proteolysis
Products for Proteolysis
- Cat.No. Product Name Information
- GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC49390 13C6-4-Nitroaniline An internal standard for the quantification of 4-nitroaniline
- GC18359 4-Epianhydrochlortetracycline (hydrochloride) 4-Epianhydrochlortetracycline is a derivative of tetracycline .
- GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
- GC41423 5-trans Prostaglandin E2 5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1.
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GC40202
7α-hydroxy Cholesterol-d7
7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.
- GC42665 AAF-CMK (trifluoroacetate salt) Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.
- GC42683 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1).
- GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase
- GC42684 Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt) Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1).
- GA20494 Ac-Asp-Glu-Val-Asp-pNA The cleavage of the chromogenic caspase-3 substrate Ac-DEVD-pNA can be monitored at 405 nm.
- GC48470 Ac-DEVD-CHO (trifluoroacetate salt) A dual caspase3/caspase7 inhibitor
- GC42689 Ac-DNLD-AMC Ac-WLA-AMC is a fluorogenic substrate of caspase-3.
- GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11
- GC18226 Ac-LEHD-AMC (trifluoroacetate salt) Ac-LEHD-AMC (trifluoroacetate salt) is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm).
- GC40556 Ac-LETD-AFC Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8.
- GC13400 Ac-VDVAD-AFC Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer.
- GC52372 Ac-VDVAD-AFC (trifluoroacetate salt) A fluorogenic substrate for caspase-2
- GC48974 Ac-VEID-AMC (ammonium acetate salt) A caspase-6 fluorogenic substrate
- GC18021 Ac-YVAD-CHO Selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1)
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GC42721
Ac-YVAD-CMK
Ac-YVAD-CMK is a selective irreversible inhibitor of caspase-1 (Ki=0.8nM), which can prevent the proinflammatory cytokine IL-1β activation. Ac-YVAD-CMK can reduce the inflammatory response and induce a long-lasting neuroprotective effect.
- GC42788 Aminopeptidase N Inhibitor Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).
- GC46867 Apremilast-d5 An internal standard for the quantification of apremilast
- GC46878 Aranciamycin A fungal metabolite with diverse biological activities
- GC46895 Aurintricarboxylic Acid (ammonium salt) A protein synthesis inhibitor with diverse biological activities
- GC46937 Boc-Glu-OBzl An amino acid-containing building block
- GC45394 Bz-IEGR-pNA (acetate)
- GC18315 Calpain Inhibitor VI Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases u-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM).
- GC43150 CAY10406 CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7.
- GC43154 CAY10443 Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome.
- GC47079 Chloramine-T (hydrate) A common reagent
- GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt) A colorimetric chymotrypsin substrate
- GC18421 Dabcyl-YVADAPV-EDANS Dabcyl-YVADAPV-EDANS is a fluorogenic substrate for caspase-1.
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GC43371
Dabigatran Acyl-β-D-Glucuronide
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran.
- GC49684 Dabigatran-13C-d3 An internal standard for the quantification of dabigatran
- GC49682 Dabigatran-d3 An internal standard for the quantification of dabigatran
- GC43545 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9.
- GC43546 Dnp-PLALWAR (trifluoroacetate salt) Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8.
- GC43547 Dnp-PLAYWAR (trifluoroacetate salt) Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26.
- GC43550 Dnp-PLGMWSR (trifluoroacetate salt) Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9.
- GC43552 Dnp-RPLALWRS (trifluoroacetate salt) Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7).
- GC43614 Enteropeptidase Fluorogenic Substrate Enteropeptidase fluorogenic substrate is a substrate for enteropeptidase that contains a 7-amino-4-trifluoromethylcoumarin (AFC) moiety.
- GC48995 Enteropeptidase Fluorogenic Substrate (trifluoroacetate salt) A fluorogenic substrate of enteropeptidase
- GC49322 GGACK (hydrochloride) A uPA and factor Xa inhibitor
- GC49437 Gliotoxin-13C13 An internal standard for the quantification of gliotoxin
- GC45668 Gly-Arg-AMC (hydrochloride) A fluorogenic substrate for cathepsin C
- GA22303 H-D-Pro-Phe-Arg-pNA . 2 HCl pFR-pNA, chromogenic substrate for the determination of plasma kallikrein-like activity. CAS Number (net): 64816-19-9.
- GC45471 H-Gly-Arg-pNA (hydrochloride)
- GC49605 H-Gly-Pro-Hyp-OH (acetate) A peptide DPP-4 inhibitor
- GC49915 Hexa-D-Arginine (trifluoroacetate salt) A furin inhibitor
- GC45639 Hexapeptide-11 (acetate) A synthetic hexapeptide
- GC48387 Inostamycin A A bacterial metabolite with anticancer activity
- GC52472 Inostamycin A (sodium salt) A bacterial metabolite with anticancer activity
- GC49142 Isorhoifolin A flavonoid glycoside with diverse biological activities
- GC43922 Isovaleryl-L-carnitine (chloride) Isovaleryl-L-carnitine (chloride), a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils.
- GC18699 JCP174 An inhibitor of palmitoyl protein thioesterase-1
- GC49547 L-Glutamic Acid γ-p-Nitroanilide (hydrate) A colorimetric substrate for γ-glutamyl transpeptidase
- GC49205 L-Leu-AMC (hydrochloride) L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase).
- GC49751 Lefamulin Lefamulin (BC-3781) is an orally active antibiotic.
- GC18363 Mca-DEVDAPK(Dnp)-OH Mca-DEVDAPK(Dnp)-OH is a fluorogenic substrate for caspase-3.
- GC44132 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).
- GC44235 MMP Inhibitor I (trifluoroacetate salt) MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively).
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GC18218
MMP-3 Inhibitor
MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with a Ki value of 95 nM.
- GC40624 MMP-3 Inhibitor VIII Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.
- GC18616 MMP-8 Inhibitor I MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.
- GC45515 MX1013
- GC45667 N-(p-Tosyl)-GPR-pNA (acetate) A colorimetric thrombin substrate
- GC47806 N-p-Tosyl-Gly-Pro-Lys-pNA (acetate) A colorimetric plasmin substrate
- GC44313 Naphthofluorescein Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway.
- GC49186 O-Demethyl Apremilast An active metabolite of apremilast
- GC40256 p-APMSF (hydrochloride) p-APMSF is an irreversible inhibitor of serine proteases with Ki values of 1.02, 1.18, 1.5, and 1.54 μM for bovine trypsin, human thrombin, bovine plasmin, and bovine Factor Xa, respectively.
- GC49024 Palmitic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC49023 Palmitic Acid-d9 MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC49702 Papain Inhibitor (trifluoroacetate salt) A peptide inhibitor of papain
- GC40622 Penicillide Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities.
- GC40265 Pheleuin Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde.
- GC46019 Pluviatolide A lignan
- GC49108 Racecadotril-d5 An internal standard for the quantification of racecadotril
- GC48101 SSAA09E1 A SARS-CoV entry inhibitor
- GC18565 Suc-AAP-Abu-pNA Suc-AAP-Abu-pNA is a chromogenic peptide substrate for pancreatic elastase.
- GC52447 Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) A fluorogenic substrate for the 20S proteasome and calpains
- GC44963 Suc-Leu-Tyr-AMC The calpains are a family of calcium-dependent cysteine proteases, with calpain I (μ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium.
- GA23570 Suc-Tyr-Val-Ala-Asp-pNA Suc-YVAD-pNA, a chromogenic caspase-1 substrate.
- GC44967 Suc-YVAD-AMC (acetate) Suc-YVAD-AMC is a fluorogenic substrate for caspase-1.
- GC48764 Sydowinin B A xanthone polyketide with immunosuppressant activity
- GC48174 Thiorphan-d5 An internal standard for the quantification of thiorphan
- GC45066 Tosyl Phenylalanyl Chloromethyl Ketone Tosyl Phenylalanyl Chloromethyl Ketone (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-Tosyl Phenylalanyl Chloromethyl Ketone) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability.
- GC49685 Trifluoroacetyl Tripeptide-2 (acetate) A peptide inhibitor of pancreatic and neutrophil elastases
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GC45086
Trigalacturonic Acid
Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 μg/plant).
- GC49835 Tumulosic Acid Tumulosic Acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM).
- GC48471 Z-(L-Arg)-AMC (hydrochloride) Z-(L-Arg)-AMC (hydrochloride) is a fluorogenic substrate for trypsin and papain.
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GC45177
Z-AEVD-FMK
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.
- GA23742 Z-D-Arg-Gly-Arg-pNA . 2 HCl Z-RGR-pNA is a chromogenic substrate for the determination of factor Xa.
- GC13859 Z-DEVD-AFC A caspase-3 fluorogenic substrate
- GC49145 Z-FR-AMC (trifluoroacetate salt) A fluorogenic substrate for cathepsin L
- GC45181 Z-IETD-AFC Z-IETD-AFC is a fluorogenic substrate for caspase-8 and granzyme B.
- GC40151 Z-VAD-AMC (acetate) Z-VAD-AMC is a fluorogenic substrate for caspase-1.