Wee1
Wee1 is a tyrosine kinase nuclear protein that catalyzes tyrosine phosphorylation of CDC2/Cyclin B kinase. It negatively regulates the entry to mitosis by protecting nucleus from cytoplasmically activated CDC2 kinase.
Products for Wee1
- Cat.No. Product Name Information
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GC16030
MK-1775
MK1775,MK 1775
MK-1775 is a potent and selective small-molecule inhibitor of Wee1 kinase with an IC50 value of 5.2 nM. -
GC50045
PD 166285 dihydrochloride
PD 166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD 166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1.
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GC38216
PD 407824
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GC32853
PD0166285
PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1.
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GC72924
PD173952
PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively.
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GC71010
RSS0680
RSS0680 (Example 22) is a bifunctional compound targeted protein degradation of kinases.
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GC62449
WEE1-IN-3
WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. WEE1-IN-3 has anticancer activities.
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GC65994
WEE1-IN-5
WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer.
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GC62697
ZN-c3