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DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC32333 Beaucage reagent Beaucage reagent is found to be potent in causing DNA cleavage. Beaucage reagent  Chemical Structure
  3. GC42912 Becatecarin Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. Becatecarin  Chemical Structure
  4. GC33066 Belotecan hydrochloride (CKD-602) Belotecan hydrochloride (CKD-602) (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. Belotecan hydrochloride (CKD-602)  Chemical Structure
  5. GC64354 Bendamustine Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties. Bendamustine  Chemical Structure
  6. GC34305 Bendamustine D4 (SDX-105 D4) Bendamustine D4 (SDX-105 D4)  Chemical Structure
  7. GC10744 Bendamustine HCl Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties. Bendamustine HCl  Chemical Structure
  8. GC49781 Benomyl A carbamate pesticide Benomyl  Chemical Structure
  9. GC12844 Benzamide poly (ADP-ribose) synthetase inhibitor Benzamide  Chemical Structure
  10. GC30763 Benzenebutyric acid (4-Phenylbutyric acid) Benzenebutyric acid (4-Phenylbutyric acid) (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Benzenebutyric acid (4-Phenylbutyric acid)  Chemical Structure
  11. GN10221 Berberine

    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.

    Berberine  Chemical Structure
  12. GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Berberine chloride hydrate  Chemical Structure
  13. GN10208 Berberine hydrochloride

    Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.

    Berberine hydrochloride  Chemical Structure
  14. GN10523 Berberine Sulfate Berberine Sulfate  Chemical Structure
  15. GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression. Beta-Lapachone  Chemical Structure
  16. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid  Chemical Structure
  17. GC12074 BG45 Novel HDAC3-selective inhibitor BG45  Chemical Structure
  18. GC19067 BGG463 BGG463 is a CDK2 inhibitor. BGG463  Chemical Structure
  19. GC14380 BGP-15 PARP inhibitor BGP-15  Chemical Structure
  20. GC35512 BI-1347 BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM). BI-1347 shows anti-tumoral activity. BI-1347  Chemical Structure
  21. GC13636 BIBR 1532 Telomerase inhibitor,novel and selective BIBR 1532  Chemical Structure
  22. GC62653 bio-THZ1 bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. bio-THZ1  Chemical Structure
  23. GC25139 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Biphenyl-4-sulfonyl chloride  Chemical Structure
  24. GC19073 Bisantrene Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. Bisantrene  Chemical Structure
  25. GC18354 Bisindolylmaleimide X (hydrochloride) Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). Bisindolylmaleimide X (hydrochloride)  Chemical Structure
  26. GC18094 Blasticidin S HCl

    Blasticidin S HCl is a nucleoside antibiotic isolated from Streptomyces griseochromogenes[1].

    Blasticidin S HCl  Chemical Structure
  27. GC60089 Bleomycin hydrochloride Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic. Bleomycin hydrochloride  Chemical Structure
  28. GC15819 Bleomycin Sulfate

    Bleomycin is produced by Streptomyces verticillis.

    Bleomycin Sulfate  Chemical Structure
  29. GC15190 BMH-21 RNA polymerase I Inhibitior BMH-21  Chemical Structure
  30. GC12822 BML-210(CAY10433) BML-210(CAY10433) is a novel HDAC inhibitor, and its mechanism of action has not been characterized. BML-210(CAY10433)  Chemical Structure
  31. GC11648 BML-277 Chk2 inhibitor,potent and highly selective BML-277  Chemical Structure
  32. GC19076 BMS-3 BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. BMS-3  Chemical Structure
  33. GC12865 BMS265246 CDK1/2 inhibitor,potent and selective BMS265246  Chemical Structure
  34. GC34498 Bobcat339 hydrochloride Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription. Bobcat339 hydrochloride  Chemical Structure
  35. GC11040 Borrelidin threonyl-tRNA synthetase (ThrRS) inhibitor Borrelidin  Chemical Structure
  36. GC48365 Bottromycin A2 An antibiotic Bottromycin A2  Chemical Structure
  37. GC35547 BR102375 BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%. BR102375  Chemical Structure
  38. GC50140 BRACO 19 trihydrochloride

    Telomerase inhibitor

    BRACO 19 trihydrochloride  Chemical Structure
  39. GC62128 Bractoppin Bractoppin is a inhibitor of phosphopeptide recognition by the human BRCA1 tBRCT domain with IC50 of 74 nM. Bractoppin  Chemical Structure
  40. GC32702 Branaplam (LMI070) Branaplam (LMI070) (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam (LMI070) inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam (LMI070) elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model. Branaplam (LMI070)  Chemical Structure
  41. GC64383 Branaplam hydrochloride Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model. Branaplam hydrochloride  Chemical Structure
  42. GC33223 BRCA1-IN-1 BRCA1-IN-1 is a novel small-molecule-like BRCA1 inhibitor with IC50 and Ki of 0.53 μM and 0.71 μM, respecrively. BRCA1-IN-1  Chemical Structure
  43. GC35550 BRCA1-IN-2 BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions. BRCA1-IN-2  Chemical Structure
  44. GC33331 BRD 4354 BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354  Chemical Structure
  45. GC35551 BRD 4354 ditrifluoroacetate BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 ditrifluoroacetate  Chemical Structure
  46. GC50452 BRD 6989 Cdk8 inhibitor; enhances IL-10 production BRD 6989  Chemical Structure
  47. GC38742 BRD-6929 An HDAC1 and HDAC2 inhibitor BRD-6929  Chemical Structure
  48. GC64111 BRD0539 BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539  Chemical Structure
  49. GC12484 BRD73954 potent and selective HDAC inhibitor BRD73954  Chemical Structure
  50. GC17683 Brefeldin A

    Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.

    Brefeldin A  Chemical Structure
  51. GC19083 Briciclib Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. Briciclib  Chemical Structure
  52. GC42978 Bromamphenicol Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol. Bromamphenicol  Chemical Structure
  53. GC50217 BS 181 dihydrochloride Selective cdk7 inhibitor BS 181 dihydrochloride  Chemical Structure
  54. GC12001 BS-181 A selective Cdk7 inhibitor BS-181  Chemical Structure
  55. GC13690 BS-181 HCl BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. BS-181 HCl  Chemical Structure
  56. GC65128 BSJ-03-123 BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader. BSJ-03-123  Chemical Structure
  57. GC50615 BSJ-03-204 Selective Cdk4/6 degrader BSJ-03-204  Chemical Structure
  58. GC62263 BSJ-4-116 BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib. BSJ-4-116  Chemical Structure
  59. GC62880 BTX161 BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2. BTX161  Chemical Structure
  60. GC15410 Bufexamac COX inhibitor Bufexamac  Chemical Structure
  61. GC13671 Busulfan DNA alkylating agent Busulfan  Chemical Structure
  62. GC46962 Busulfan-d8 An internal standard for the quantification of busulfan Busulfan-d8  Chemical Structure
  63. GC64761 Butyric acid-13C1 Butyric acid-13C1  Chemical Structure
  64. GC62136 BVDV-IN-1 BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1  Chemical Structure
  65. GC61735 Bz-rA Phosphoramidite Bz-rA Phosphoramidite is used for ribonucleotides modification. Bz-rA Phosphoramidite  Chemical Structure
  66. GC66885 Bz-rC Phosphoramidite Bz-rC Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides. Bz-rC Phosphoramidite  Chemical Structure
  67. GC13892 C527 Inhibitor of USP1/USF1 complex C527  Chemical Structure
  68. GC43109 C8 D-threo Ceramide (d18:1/8:0) C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. C8 D-threo Ceramide (d18:1/8:0)  Chemical Structure
  69. GC43111 C8 L-threo Ceramide (d18:1/8:0) C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. C8 L-threo Ceramide (d18:1/8:0)  Chemical Structure
  70. GC30977 Ca2+ channel agonist 1 Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. Ca2+ channel agonist 1  Chemical Structure
  71. GC15306 Calcium N5-methyltetrahydrofolate Calcium salt of levomefolic acid Calcium N5-methyltetrahydrofolate  Chemical Structure
  72. GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin  Chemical Structure
  73. GC15439 Camptothecin

    Topoisomerase I inhibitor

    Camptothecin  Chemical Structure
  74. GC60669 Camptothecin-20(S)-O-propionate Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor. Camptothecin-20(S)-O-propionate  Chemical Structure
  75. GC15866 Capecitabine DNA, RNA and protein synthesis inhibitor Capecitabine  Chemical Structure
  76. GC49415 Capsorubin A carotenoid with diverse biological activities Capsorubin  Chemical Structure
  77. GC38896 Caracemide Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide  Chemical Structure
  78. GC11207 Carboplatin

    Antitumor agent that forms platinum-DNA adducts.

    Carboplatin  Chemical Structure
  79. GC49286 Carboplatin-d4 An internal standard for the quantification of carboplatin Carboplatin-d4  Chemical Structure
  80. GC49147 Carboxyphosphamide An inactive metabolite of cyclophosphamide Carboxyphosphamide  Chemical Structure
  81. GC12748 Carmofur Cytostatic derivative of fluorouracilm,antineoplatic agent Carmofur  Chemical Structure
  82. GC15793 Carmustine cell-cycle phase nonspecific alkylating antineoplastic agent Carmustine  Chemical Structure
  83. GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research. Casein kinase 1δ-IN-1  Chemical Structure
  84. GC67775 Casein kinase 1δ-IN-3 Casein kinase 1δ-IN-3  Chemical Structure
  85. GC30276 Casein Kinase II Inhibitor IV

    Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.

    Casein Kinase II Inhibitor IV  Chemical Structure
  86. GC34356 Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocytedifferentiation. Casein Kinase II Inhibitor IV Hydrochloride  Chemical Structure
  87. GC62442 Casein Kinase inhibitor A51 Casein Kinase inhibitor A51 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Casein Kinase inhibitor A51  Chemical Structure
  88. GC63463 Casein Kinase inhibitor A86 Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Casein Kinase inhibitor A86  Chemical Structure
  89. GC43175 CAY10574 CAY10574 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. CAY10574 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. Antitumor activity. CAY10574  Chemical Structure
  90. GC40515 CAY10577 Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase involved in many signal transduction pathways. CAY10577  Chemical Structure
  91. GC43177 CAY10578 Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CAY10578  Chemical Structure
  92. GC12971 CAY10603

    potent and selective inhibitor of HDAC6

    CAY10603  Chemical Structure
  93. GC46113 CAY10744 A topoisomerase II-α poison CAY10744  Chemical Structure
  94. GC47059 CAY10760 An inhibitor of the RAD51-BRCA2 interaction CAY10760  Chemical Structure
  95. GC52006 CB-096 An inhibitor of RAN translation CB-096  Chemical Structure
  96. GC43209 CB-1954 CB-1954 (CB 1954), an antitumor prodrug, is highly selective against the Walker 256 rat tumour line. CB-1954 is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. CB-1954 in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). CB-1954  Chemical Structure
  97. GC14058 CBHA CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis and suppresses tumor growth. CBHA  Chemical Structure
  98. GC16654 CC-115 mTOR/DNA-PK inhibitor CC-115  Chemical Structure
  99. GC34121 CC-115 hydrochloride CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. CC-115 hydrochloride  Chemical Structure
  100. GC19089 CC-671 CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC50s of 0.005 and 0.006 uM for TTK and CLK2, respectively. CC-671  Chemical Structure
  101. GC50085 CCT 241533 dihydrochloride Potent Chk2 inhibitor CCT 241533 dihydrochloride  Chemical Structure

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