DNA Damage/DNA Repair
- MTH1(4)
- PARP(84)
- ATM/ATR(30)
- DNA Alkylating(20)
- DNA Ligases(3)
- DNA Methyltransferase(25)
- DNA-PK(30)
- HDAC(136)
- Nucleoside Antimetabolite/Analogue(140)
- Telomerase(17)
- Topoisomerase(151)
- tankyrase(5)
- Antifolate(38)
- CDK(250)
- Checkpoint Kinase (Chk)(31)
- CRISPR/Cas9(9)
- Deubiquitinase(72)
- DNA Alkylator/Crosslinker(71)
- DNA/RNA Synthesis(400)
- Eukaryotic Initiation Factor (eIF)(23)
- IRE1(23)
- LIM Kinase (LIMK)(9)
- TOPK(5)
- Casein Kinase(61)
- DNA Intercalating Agents(7)
- DNA/RNA Oxidative Damage(12)
Products for DNA Damage/DNA Repair
- Cat.No. Product Name Information
- GC32333 Beaucage reagent Beaucage reagent is found to be potent in causing DNA cleavage.
- GC42912 Becatecarin Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin.
- GC33066 Belotecan hydrochloride (CKD-602) Belotecan hydrochloride (CKD-602) (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
- GC64354 Bendamustine Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties.
- GC34305 Bendamustine D4 (SDX-105 D4)
- GC10744 Bendamustine HCl Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties.
- GC49781 Benomyl A carbamate pesticide
- GC12844 Benzamide poly (ADP-ribose) synthetase inhibitor
- GC30763 Benzenebutyric acid (4-Phenylbutyric acid) Benzenebutyric acid (4-Phenylbutyric acid) (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
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GN10221
Berberine
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.
- GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
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GN10208
Berberine hydrochloride
Berberine hydrochloride is an isoquinoline alkaloid derived from the Ranunculaceae medicinal plant Coptis chinensis. It has various pharmacological activities such as anti-tumor, anti-inflammatory, and hypoglycemic activities.
- GN10523 Berberine Sulfate
- GC10734 Beta-Lapachone Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
- GC10480 Betulinic acid A plant triterpenoid similar to bile acids
- GC12074 BG45 Novel HDAC3-selective inhibitor
- GC19067 BGG463 BGG463 is a CDK2 inhibitor.
- GC14380 BGP-15 PARP inhibitor
- GC35512 BI-1347 BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM). BI-1347 shows anti-tumoral activity.
- GC13636 BIBR 1532 Telomerase inhibitor,novel and selective
- GC62653 bio-THZ1 bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM.
- GC25139 Biphenyl-4-sulfonyl chloride Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
- GC19073 Bisantrene Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases.
- GC18354 Bisindolylmaleimide X (hydrochloride) Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).
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GC18094
Blasticidin S HCl
Blasticidin S HCl is a nucleoside antibiotic isolated from Streptomyces griseochromogenes[1].
- GC60089 Bleomycin hydrochloride Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic.
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GC15819
Bleomycin Sulfate
Bleomycin is produced by Streptomyces verticillis.
- GC15190 BMH-21 RNA polymerase I Inhibitior
- GC12822 BML-210(CAY10433) BML-210(CAY10433) is a novel HDAC inhibitor, and its mechanism of action has not been characterized.
- GC11648 BML-277 Chk2 inhibitor,potent and highly selective
- GC19076 BMS-3 BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
- GC12865 BMS265246 CDK1/2 inhibitor,potent and selective
- GC34498 Bobcat339 hydrochloride Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.
- GC11040 Borrelidin threonyl-tRNA synthetase (ThrRS) inhibitor
- GC48365 Bottromycin A2 An antibiotic
- GC35547 BR102375 BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%.
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GC50140
BRACO 19 trihydrochloride
Telomerase inhibitor
- GC62128 Bractoppin Bractoppin is a inhibitor of phosphopeptide recognition by the human BRCA1 tBRCT domain with IC50 of 74 nM.
- GC32702 Branaplam (LMI070) Branaplam (LMI070) (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam (LMI070) inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam (LMI070) elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- GC64383 Branaplam hydrochloride Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- GC33223 BRCA1-IN-1 BRCA1-IN-1 is a novel small-molecule-like BRCA1 inhibitor with IC50 and Ki of 0.53 μM and 0.71 μM, respecrively.
- GC35550 BRCA1-IN-2 BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.
- GC33331 BRD 4354 BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
- GC35551 BRD 4354 ditrifluoroacetate BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.
- GC50452 BRD 6989 Cdk8 inhibitor; enhances IL-10 production
- GC38742 BRD-6929 An HDAC1 and HDAC2 inhibitor
- GC64111 BRD0539 BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9.
- GC12484 BRD73954 potent and selective HDAC inhibitor
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GC17683
Brefeldin A
Brefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.
- GC19083 Briciclib Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
- GC42978 Bromamphenicol Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol.
- GC50217 BS 181 dihydrochloride Selective cdk7 inhibitor
- GC12001 BS-181 A selective Cdk7 inhibitor
- GC13690 BS-181 HCl BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM, and > 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9.
- GC65128 BSJ-03-123 BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.
- GC50615 BSJ-03-204 Selective Cdk4/6 degrader
- GC62263 BSJ-4-116 BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib.
- GC62880 BTX161 BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2.
- GC15410 Bufexamac COX inhibitor
- GC13671 Busulfan DNA alkylating agent
- GC46962 Busulfan-d8 An internal standard for the quantification of busulfan
- GC64761 Butyric acid-13C1
- GC62136 BVDV-IN-1 BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.
- GC61735 Bz-rA Phosphoramidite Bz-rA Phosphoramidite is used for ribonucleotides modification.
- GC66885 Bz-rC Phosphoramidite Bz-rC Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides.
- GC13892 C527 Inhibitor of USP1/USF1 complex
- GC43109 C8 D-threo Ceramide (d18:1/8:0) C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.
- GC43111 C8 L-threo Ceramide (d18:1/8:0) C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.
- GC30977 Ca2+ channel agonist 1 Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.
- GC15306 Calcium N5-methyltetrahydrofolate Calcium salt of levomefolic acid
- GC19086 Calicheamicin Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks.
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GC15439
Camptothecin
Topoisomerase I inhibitor
- GC60669 Camptothecin-20(S)-O-propionate Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.
- GC15866 Capecitabine DNA, RNA and protein synthesis inhibitor
- GC49415 Capsorubin A carotenoid with diverse biological activities
- GC38896 Caracemide Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli.
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GC11207
Carboplatin
Antitumor agent that forms platinum-DNA adducts.
- GC49286 Carboplatin-d4 An internal standard for the quantification of carboplatin
- GC49147 Carboxyphosphamide An inactive metabolite of cyclophosphamide
- GC12748 Carmofur Cytostatic derivative of fluorouracilm,antineoplatic agent
- GC15793 Carmustine cell-cycle phase nonspecific alkylating antineoplastic agent
- GC66033 Casein kinase 1δ-IN-1 Casein kinase 1δ-IN-1 (compound 822) is an inhibitor of casein kinase 1 delta (CK1δ), exhibits inhibition of greater than 5%. Casein kinase 1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research.
- GC67775 Casein kinase 1δ-IN-3
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GC30276
Casein Kinase II Inhibitor IV
Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC50 of 9 nM.
- GC34356 Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocytedifferentiation.
- GC62442 Casein Kinase inhibitor A51 Casein Kinase inhibitor A51 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities.
- GC63463 Casein Kinase inhibitor A86 Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities.
- GC43175 CAY10574 CAY10574 is a potent, ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. CAY10574 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. Antitumor activity.
- GC40515 CAY10577 Casein kinase 2 (CK2) is a serine/threonine-selective protein kinase involved in many signal transduction pathways.
- GC43177 CAY10578 Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways.
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GC12971
CAY10603
potent and selective inhibitor of HDAC6
- GC46113 CAY10744 A topoisomerase II-α poison
- GC47059 CAY10760 An inhibitor of the RAD51-BRCA2 interaction
- GC52006 CB-096 An inhibitor of RAN translation
- GC43209 CB-1954 CB-1954 (CB 1954), an antitumor prodrug, is highly selective against the Walker 256 rat tumour line. CB-1954 is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. CB-1954 in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1).
- GC14058 CBHA CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis and suppresses tumor growth.
- GC16654 CC-115 mTOR/DNA-PK inhibitor
- GC34121 CC-115 hydrochloride CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
- GC19089 CC-671 CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC50s of 0.005 and 0.006 uM for TTK and CLK2, respectively.
- GC50085 CCT 241533 dihydrochloride Potent Chk2 inhibitor