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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC45353 4-oxo-27-TBDMS Withaferin A 4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.4-oxo-27-TBDMS Withaferin A induces tumor cells apoptosis. 4-oxo-27-TBDMS Withaferin A is a anticancer agent. 4-oxo-27-TBDMS Withaferin A Chemical Structure
  3. GC68557 4-Thio-2'-deoxyuridine

    4-Thio-2'-deoxyuridine is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity, targeting inert lymphatic system malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis and inducing cell apoptosis.

     4-Thio-2'-deoxyuridine Chemical Structure
  4. GC40477 4-Thiouracil 4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil Chemical Structure
  5. GC42474 4-Thiouridine 4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. 4-Thiouridine Chemical Structure
  6. GC13104 4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 4E1RCat Chemical Structure
  7. GC30785 4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 4E2RCat Chemical Structure
  8. GC10468 4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1 Chemical Structure
  9. GC12667 4SC-202 4SC-202 (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 4SC-202 Chemical Structure
  10. GC65520 5'-DMT-3'-TBDMS-ibu-rG 5'-DMT-3'-TBDMS-ibu-rG is is a modified nucleoside. 5'-DMT-3'-TBDMS-ibu-rG Chemical Structure
  11. GC65402 5'-O-DMT-2'-O-TBDMS-Bz-rC 5'-O-DMT-2'-O-TBDMS-Bz-rC is a modified nucleoside and can be used to synthesize DNA or RNA. 5'-O-DMT-2'-O-TBDMS-Bz-rC Chemical Structure
  12. GC65164 5'-O-DMT-2'-O-TBDMS-rI 5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI Chemical Structure
  13. GC65396 5'-O-DMT-ibu-dC 5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides. 5'-O-DMT-ibu-dC Chemical Structure
  14. GC64982 5'-O-DMT-N2-DMF-dG 5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-N2-DMF-dG Chemical Structure
  15. GC65482 5'-O-DMT-N6-ibu-dA 5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides. 5'-O-DMT-N6-ibu-dA Chemical Structure
  16. GC65562 5'-O-DMT-N6-Me-2'-dA 5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects. 5'-O-DMT-N6-Me-2'-dA Chemical Structure
  17. GC65401 5'-O-TBDMS-dU 5'-O-TBDMS-dU can be used in the synthesis of oligoribonucleotides. 5'-O-TBDMS-dU Chemical Structure
  18. GC62157 5’-O-DMT-2’-O-TBDMS-Ac-rC 5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA. 5’-O-DMT-2’-O-TBDMS-Ac-rC Chemical Structure
  19. GC62149 5’-O-DMT-2’-TBDMS-Uridine 5’-O-DMT-2’-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis. 5’-O-DMT-2’-TBDMS-Uridine Chemical Structure
  20. GC62532 5’-O-DMT-3’-O-TBDMS-Ac-rC 5’-O-DMT-3’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA. 5’-O-DMT-3’-O-TBDMS-Ac-rC Chemical Structure
  21. GC62573 5’-O-DMT-Bz-rC 5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA. 5’-O-DMT-Bz-rC Chemical Structure
  22. GC62574 5’-O-DMT-N4-Ac-2’-F-dC 5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA. 5’-O-DMT-N4-Ac-2’-F-dC Chemical Structure
  23. GC62575 5’-O-DMT-N4-Bz-2’-F-dC 5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects. 5’-O-DMT-N4-Bz-2’-F-dC Chemical Structure
  24. GC62576 5’-O-DMT-N4-Bz-5-Me-dC 5’-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside. 5’-O-DMT-N4-Bz-5-Me-dC Chemical Structure
  25. GC62812 5’-O-DMT-PAC-dA 5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides. 5’-O-DMT-PAC-dA Chemical Structure
  26. GC62813 5’-O-DMT-rI 5'-O-DMT-Ri can be used in the synthesis of oligoribonucleotides. 5’-O-DMT-rI Chemical Structure
  27. GC62577 5’-O-DMT-rU 5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA. 5’-O-DMT-rU Chemical Structure
  28. GC62578 5’-O-TBDMS-Bz-dA 5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects. 5’-O-TBDMS-Bz-dA Chemical Structure
  29. GC62579 5’-O-TBDMS-dA 5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA. 5’-O-TBDMS-dA Chemical Structure
  30. GC62580 5’-O-TBDMS-dG 5’-O-TBDMS-dG is a modified nucleoside. 5’-O-TBDMS-dG Chemical Structure
  31. GC62581 5’-O-TBDMS-dT 5’-O-TBDMS-dT is a nucleoside with protective and modification effects. 5’-O-TBDMS-dT Chemical Structure
  32. GC40641 5'-Ethynyl-2'-deoxycytidine 5'-Ethynyl-2'-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 μg/mL). 5'-Ethynyl-2'-deoxycytidine Chemical Structure
  33. GC61432 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine?is an adenosine derivative and can be used as an intermediate for oligonucleotides synthesis. 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine Chemical Structure
  34. GC61726 5'-O-DMT-N4-Ac-dC 5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis. 5'-O-DMT-N4-Ac-dC Chemical Structure
  35. GC48662 5'-Thymidylic Acid (sodium salt) 5'-Thymidylic Acid (sodium salt) is an endogenous metabolite. 5'-Thymidylic Acid (sodium salt) Chemical Structure
  36. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 5,7,4'-Trimethoxyflavone Chemical Structure
  37. GC68161 5-AIQ 5-AIQ Chemical Structure
  38. GC64952 5-Aza-7-deazaguanine 5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides. 5-Aza-7-deazaguanine Chemical Structure
  39. GC10946 5-Azacytidine

    A DNA methyltransferase inhibitor

     5-Azacytidine Chemical Structure
  40. GC11940 5-BrdU

    Synthetic thymidine analog

     5-BrdU Chemical Structure
  41. GC46681 5-Bromouridine A brominated uridine analog 5-Bromouridine Chemical Structure
  42. GC49245 5-Ethynyluridine 5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine Chemical Structure
  43. GC42545 5-Fluorouracil-13C,15N2 5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil-13C,15N2 Chemical Structure
  44. GC46033 5-Heneicosylresorcinol An alkylresorcinol 5-Heneicosylresorcinol Chemical Structure
  45. GC62389 5-Iminodaunorubicin 5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells. 5-Iminodaunorubicin Chemical Structure
  46. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime Chemical Structure
  47. GC66658 5-Me-dC(Ac) amidite 5-Me-dC(Ac) amidite is used for synthesizing DNA or RNA. 5-Me-dC(Ac) amidite Chemical Structure
  48. GC31187 5-Methoxyflavone 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. 5-Methoxyflavone Chemical Structure
  49. GC42562 5-Methyl-2'-deoxycytidine 5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. 5-Methyl-2'-deoxycytidine Chemical Structure
  50. GC67671 5-Methylcytidine 5′-triphosphate trisodium 5-Methylcytidine 5′-triphosphate trisodium Chemical Structure
  51. GC35166 5-Methylcytosine 5-Methylcytosine is a well-characterized DNA modification, and is also predominantly in abundant non-coding RNAs in both prokaryotes and eukaryotes. 5-Methylcytosine Chemical Structure
  52. GC62547 5-O-TBDMS-N4-Benzoyl-2-deoxycytidine 5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside. 5-O-TBDMS-N4-Benzoyl-2-deoxycytidine Chemical Structure
  53. GC66055 5-Phenylpentan-2-one 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. 5-Phenylpentan-2-one Chemical Structure
  54. GC46713 5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate) An intermediate in several biochemical pathways 5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate) Chemical Structure
  55. GC46079 5-Tricosylresorcinol 5-Tricosylresorcinolthe is the first cyst lipid. 5-Tricosylresorcinol Chemical Structure
  56. GC45772 6(5H)-Phenanthridinone An inhibitor of PARP1 and 2 6(5H)-Phenanthridinone Chemical Structure
  57. GC60532 6-(Dimethylamino)purine 6-(Dimethylamino)purine is a dual inhibitor of protein kinase and CDK. 6-(Dimethylamino)purine Chemical Structure
  58. GC30548 6-Amino-5-nitropyridin-2-one 6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine. 6-Amino-5-nitropyridin-2-one Chemical Structure
  59. GC60031 6-Azathymine 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine Chemical Structure
  60. GC50249 6-Hydroxy-DL-DOPA 6-Hydroxy-DL-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DL-DOPA can be used for the research of cancer. 6-Hydroxy-DL-DOPA Chemical Structure
  61. GC32975 6-Mercaptopurine hydrate An inhibitor of purine synthesis and interconversion 6-Mercaptopurine hydrate Chemical Structure
  62. GC35180 6-Methyl-5-azacytidine 6-Methyl-5-azacytidine is a potent DNMT inhibitor. 6-Methyl-5-azacytidine Chemical Structure
  63. GC49235 6-Methylmercaptopurine A metabolite of 6-mercaptopurine 6-Methylmercaptopurine Chemical Structure
  64. GC49488 6-Methylmercaptopurine-d3 An internal standard for the quantification of 6-MMP 6-Methylmercaptopurine-d3 Chemical Structure
  65. GC65082 6-O-Methyl Guanosine 6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine Chemical Structure
  66. GC12193 6-Thio-dG 6-Thio-dG is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. 6-Thio-dG Chemical Structure
  67. GC35171 6-Thioinosine 6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα. 6-Thioinosine Chemical Structure
  68. GC39625 6RK73 6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 ?M. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 ?M). 6RK73 specifically inhibit UCHL1 activity in breast cancer. 6RK73 Chemical Structure
  69. GC46733 7,12-Dimethylbenz[a]anthracene 7,12-Dimethylbenz[a]anthracene has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). 7,12-Dimethylbenz[a]anthracene is used to induce tumor formation in various rodent models. 7,12-Dimethylbenz[a]anthracene Chemical Structure
  70. GC33577 7-Aminoactinomycin D (7-AAD) 7-Aminoactinomycin D (7-AAD) (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D (7-AAD) Chemical Structure
  71. GC65408 7-Deaza-2'-deoxy-7-iodoadenosine 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine. 7-Deaza-2'-deoxy-7-iodoadenosine Chemical Structure
  72. GC66060 7-Iodo-2',3'-dideoxy-7-deaza-guanosine 7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions. 7-Iodo-2',3'-dideoxy-7-deaza-guanosine Chemical Structure
  73. GC65675 7-Iodo-7-deaza-2'-deoxyguanosine 7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a deoxyguanosine derivative that can be used in DNA synthesis and sequencing reactions. 7-Iodo-7-deaza-2'-deoxyguanosine Chemical Structure
  74. GC30531 7-Methylguanosine A nucleotide analog 7-Methylguanosine Chemical Structure
  75. GC49561 7-Methylguanosine-d3 An internal standard for the quantification of 7-methylguanosine 7-Methylguanosine-d3 Chemical Structure
  76. GC66058 7-TFA-ap-7-Deaza-dA 7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid. 7-TFA-ap-7-Deaza-dA Chemical Structure
  77. GC65525 7-TFA-ap-7-Deaza-dG 5'-O-TBDMS-dG is a modified nucleoside. 7-TFA-ap-7-Deaza-dG Chemical Structure
  78. GC12777 8-Chloroadenosine Nucleoside analog, inhibits RNA synthesis 8-Chloroadenosine Chemical Structure
  79. GC42627 8-Hydroxyguanine (hydrochloride) 8-Hydroxyguanine is produced by oxidative degradation of DNA by hydroxyl radical. 8-Hydroxyguanine (hydrochloride) Chemical Structure
  80. GC18426 8-Nitroguanine 8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents. 8-Nitroguanine Chemical Structure
  81. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid 9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid Chemical Structure
  82. GC11903 9-amino Camptothecin 9-amino Camptothecin (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity. 9-amino Camptothecin Chemical Structure
  83. GC45367 9-Hydroxyellipticine (hydrochloride)   9-Hydroxyellipticine (hydrochloride) Chemical Structure
  84. GN10035 9-Methoxycamptothecin 9-Methoxycamptothecin Chemical Structure
  85. GC48840 9-Methoxyellipticine An alkaloid with anticancer activity 9-Methoxyellipticine Chemical Structure
  86. GC60037 A-3 hydrochloride A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride Chemical Structure
  87. GC13805 Abacavir Abacavir Chemical Structure
  88. GC63728 Abemaciclib metabolite M18 hydrochloride Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib, is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader. Abemaciclib metabolite M18 hydrochloride Chemical Structure
  89. GC38749 Abemaciclib metabolite M20 Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer. Abemaciclib metabolite M20 Chemical Structure
  90. GC35218 Abemaciclib Metabolites M2 Abemaciclib Metabolites M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity. Abemaciclib Metabolites M2 Chemical Structure
  91. GC64280 Abemaciclib-d8 Abemaciclib-d8 (LY2835219-d8) is the deuterium labeled Abemaciclib. Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively. Abemaciclib-d8 Chemical Structure
  92. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  93. GC61763 Ac-rC Phosphoramidite Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA). Ac-rC Phosphoramidite Chemical Structure
  94. GC34090 Acelarin (NUC-1031) Acelarin (NUC-1031) (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. Acelarin (NUC-1031) Chemical Structure
  95. GC35238 Aclacinomycin A hydrochloride Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors. Aclacinomycin A hydrochloride Chemical Structure
  96. GC49804 Acridine An azaarene Acridine Chemical Structure
  97. GC16866 Actinomycin D

    A DNA-interacting transcription blocker with anti-cancer activity

     Actinomycin D Chemical Structure
  98. GC35247 ACX-362E ACX-362E (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. ACX-362E Chemical Structure
  99. GC34458 ACY-1083

    ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

     ACY-1083 Chemical Structure
  100. GC10417 ACY-241 ACY-241 (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). ACY-241 has anticancer effects. ACY-241 Chemical Structure
  101. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM. ACY-738 Chemical Structure

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