DNA Damage/DNA Repair
- MTH1(4)
- PARP(84)
- ATM/ATR(30)
- DNA Alkylating(20)
- DNA Ligases(3)
- DNA Methyltransferase(25)
- DNA-PK(30)
- HDAC(136)
- Nucleoside Antimetabolite/Analogue(140)
- Telomerase(17)
- Topoisomerase(151)
- tankyrase(5)
- Antifolate(38)
- CDK(250)
- Checkpoint Kinase (Chk)(31)
- CRISPR/Cas9(9)
- Deubiquitinase(72)
- DNA Alkylator/Crosslinker(71)
- DNA/RNA Synthesis(400)
- Eukaryotic Initiation Factor (eIF)(23)
- IRE1(23)
- LIM Kinase (LIMK)(9)
- TOPK(5)
- Casein Kinase(61)
- DNA Intercalating Agents(7)
- DNA/RNA Oxidative Damage(12)
Products for DNA Damage/DNA Repair
- Cat.No. Product Name Information
- GC30782 ACY-775 An HDAC6 inhibitor
- GC30526 ACY-957 ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
- GC17186 Acyclovir Antiviral agent
- GC13432 Adenine High affinity adenine receptor agonist
- GC11825 Adenine HCl Adenine HCl (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine HCl acts as a chemical component of DNA and RNA. Adenine HCl also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
- GC17278 Adenine sulfate Adenine sulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine sulfate acts as a chemical component of DNA and RNA. Adenine sulfate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
- GC67946 Adenine-d1
- GC14106 Adenosine nucleoside
- GC49004 Adenosine 3’-monophosphate (sodium salt hydrate) A nucleotide
- GC42732 Adenosine 3',5'-diphosphate (sodium salt) Adenosine 3',5'-diphosphate (sodium salt) is an hydroxysteroid sulfotransferases inhibitor.
- GC65462 Adenosine 5′-monophosphoramidate sodium Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis.
- GC49285 Adenosine 5’-methylenediphosphate (hydrate) An inhibitor of ecto-5’-nucleotidase
- GC42733 Adenosine 5'-monophosphate (sodium salt hydrate) Adenosine 5'-monophosphate (AMP) is a central nucleotide with functions in metabolism and cell signaling.
- GC42734 Adenosine 5'-phosphosulfate (sodium salt) Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S.
- GC49231 Adenylosuccinic Acid (ammonium salt) A purine nucleotide and an intermediate in the purine nucleotide cycle
- GC65330 AES-135 AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM.
- GC46810 Aflatoxin B1-13C17 An internal standard for the quantification of aflatoxin B1
- GC62470 AG-636 AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects.
- GC42765 Aldehyde Reactive Probe (trifluoroacetate salt) DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis.
- GC14858 Aldoxorubicin An albumin-binding prodrug of doxorubicin
- GC15841 Alsterpaullone CDKs and GSK3β inhibitor
- GC67984 Alteminostat
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GC10779
Alternariol
A mycotoxin with antifungal and phytotoxic activity
- GC18437 Alternariol monomethyl ether Alternariol monomethyl ether, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species.
- GC49039 Althiomycin A thiazole antibiotic
- GC14564 Altretamine Antineoplastic agent
- GC35310 Altretamine hydrochloride Altretamine hydrochloride is an alkylating antineoplastic agent.
- GC64638 ALV1 ALV1 is a potent Ikaros and Helios degrader.
- GC64818 AMA-37 AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively.
- GC42783 Ametantrone Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break.
- GC50366 AMG 18 hydrochloride AMG 18 hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
-
GC14899
AMG 548
P38α inhibitor,potent and selective
- GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective
- GC35315 AMG 925 HCl AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
- GC38518 AMG-548 dihydrochloride AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ.
- GC42789 Aminopterin Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis.
- GC11019 Amonafide DNA intercalator,Topo II inhibitor
- GC15644 Amrubicin A synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic.
- GC12326 Amsacrine Topoisomerase 2 inhibitor
- GC11747 Amsacrine hydrochloride Topoisomerase 2 inhibitor
- GC39284 ANI-7 ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines.
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GC11559
Anisomycin
JNK agonist, potent and specific
-
GC68667
Anticancer agent 73
Anticancer agent 73 (compound CIB-3b) is an anticancer drug that targets TAR RNA binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 has inhibitory effects on the proliferation and metastasis of hepatocellular carcinoma (HCC) cells both in vitro and in vivo.
- GC40032 Antipain (hydrochloride) Antipain (hydrochloride) is a protease inhibitor isolated from Actinomycetes.
- GC68448 AOH1160
- GC67876 APE1-IN-1
- GC17139 APY29 IRE1α inhibitor
- GC45385 Ara-G
- GC62425 ARN-21934 ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research.
- GC46880 ARN24139 A topoisomerase II poison
- GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19
- GC38737 AS2863619 free base AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases.
- GC38463 ASLAN003 ASLAN003 (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice.
- GC61821 AT-130 AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor.
- GC15870 AT7519 Multi-CDK inhibitor
- GC13998 AT7519 Hydrochloride A Cdk inhibitor
- GC15597 AT7519 trifluoroacetate
- GC65327 ATM Inhibitor-5 ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1).
- GC65514 ATR inhibitor 1 ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ.
-
GC68707
ATR-IN-4
ATR-IN-4 is an effective ATR inhibitor. ATR-IN-4 inhibits the growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460, with IC50 values of 130.9 nM and 41.33 nM, respectively (excerpted from patent CN112142744A, compound 13).
- GC34422 Atuveciclib (BAY-1143572)
- GC34059 Atuveciclib Racemate (BAY-1143572 Racemate) Atuveciclib Racemate (BAY-1143572 Racemate) (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib. Atuveciclib is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM.
- GC34421 Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer)
- GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively.
- GC46895 Aurintricarboxylic Acid (ammonium salt) A protein synthesis inhibitor with diverse biological activities
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GC40005
Aurodox
Aurodox is a polyketide antibiotic originally isolated from S.
- GC60062 AV-153 free base AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity.
- GC67960 AVG-233
- GC63449 Avotaciclib Avotaciclib (BEY1107) is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). Avotaciclib can be used for the research of locally advanced or metastatic pancreatic cancer.
- GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
- GC14949 AZ20 A potent, selective ATR inhibitor
- GC19047 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 uM for ATM in cell.
- GC65899 AZ3391 AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23).
- GC16725 AZ6102 TNKS1/2 inhibitor
- GC46900 AZ9482 A PARP inhibitor
- GC11843 Azaguanine-8 Azaguanine-8 is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.
- GC15033 Azathioprine purine synthesis and GTP-binding protein Rac1 activation inhibitor
- GC50119 AZD 7762 hydrochloride Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing
- GC12438 AZD-5438 Potent CDK1/2/9 inhibitor
- GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity.
- GC11593 AZD0156 ATM kinase inhibitor
-
GC19468
AZD1390
AZD1390 is a potent and selective ATM inhibitor
- GC32717 AZD4573 AZD4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM) that enables transient target engagement for the treatment of hematologic malignancies.
- GC16941 AZD6738 AZD6738 (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM.
- GC10546 AZD7762 Checkpoint kinase inhibitor,ATP competitive
- GC60616 AZT triphosphate AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT).
- GC60617 AZT triphosphate TEA AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) is a active triphosphate metabolite of Zidovudine (AZT).
- GC33406 B I09 B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
- GC33240 Banoxantrone D12 (AQ4N D12) Banoxantrone D12 (AQ4N D12) is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
- GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) Banoxantrone-d12 (AQ4N-d12) dihydrochloride is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
- GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride) Banoxantrone dihydrochloride (AQ4N dihydrochloride) is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
-
GC13035
Bay 11-7821
A selective and irreversible NF-κB inhibitor
- GC50656 BAY 707 BAY 707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY 707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy.
- GC33420 BAY-1895344 BAY-1895344 (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. BAY-1895344 has anti-tumor activity. BAY-1895344 can be used for the research of solid tumors and lymphomas.
- GC34374 BAY-1895344 hydrochloride An ATR inhibitor
- GC32838 BAY-2402234 A DHODH inhibitor
- GC63763 BAY-8400 BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer.
- GC65259 BC-1471 BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor.
- GC50572 BC-LI-0186 Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
- GC62863 BCH001 BCH001, a quinoline derivative, is a specific PAPD5 inhibitor.