DNA Damage/DNA Repair
- MTH1(4)
- PARP(78)
- ATM/ATR(29)
- DNA Alkylating(25)
- DNA Ligases(3)
- DNA Methyltransferase(21)
- DNA-PK(31)
- HDAC(124)
- Nucleoside Antimetabolite/Analogue(160)
- Telomerase(16)
- Topoisomerase(175)
- tankyrase(5)
- Antifolate(33)
- CDK(271)
- Checkpoint Kinase (Chk)(33)
- CRISPR/Cas9(9)
- Deubiquitinase(76)
- DNA Alkylator/Crosslinker(72)
- DNA/RNA Synthesis(472)
- Eukaryotic Initiation Factor (eIF)(27)
- IRE1(23)
- LIM Kinase (LIMK)(12)
- TOPK(6)
- Casein Kinase(61)
- DNA Intercalating Agents(8)
- DNA/RNA Oxidative Damage(13)
- Poly(ADP-ribose) Glycohydrolase (PARG)(1)
- Early 2 Factor (E2F)(1)
Products for DNA Damage/DNA Repair
- Cat.No. Product Name Information
-
GC65082
6-O-Methyl Guanosine
6-O-Methyl Guanosine is a modified nucleoside.
-
GC12193
6-Thio-dG
β-TGdR; 6-Thio-2'-Deoxyguanosine
6-Thio-dG is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. -
GC35171
6-Thioinosine
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα.
-
GC39625
6RK73
6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 ?M. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 ?M). 6RK73 specifically inhibit UCHL1 activity in breast cancer.
-
GC46733
7,12-Dimethylbenz[a]anthracene
DMBA
7,12-Dimethylbenz[a]anthracene is an immunosuppressor as well as a potent organ-specific carcinogen. -
GC33577
7-Aminoactinomycin D (7-AAD)
7-AAD, NSC 239759
7-Aminoactinomycin D is a fluorescent derivative of actinomycin D that selectively binds to the GC region of DNA.
-
GC65408
7-Deaza-2'-deoxy-7-iodoadenosine
7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.
-
GC66060
7-Iodo-2',3'-dideoxy-7-deaza-guanosine
7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions.
-
GC65675
7-Iodo-7-deaza-2'-deoxyguanosine
7-Deaza-7-Iodo-2'-deoxyguanosine
7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a deoxyguanosine derivative that can be used in DNA synthesis and sequencing reactions. -
GC71545
7-Methyl-guanosine-5'-triphosphate sodium
7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate.
-
GC30531
7-Methylguanosine
m7G, 7-MeGua
A nucleotide analog -
GC49561
7-Methylguanosine-d3
m7G-d3, 7-MeGua-d3
An internal standard for the quantification of 7-methylguanosine -
GC66058
7-TFA-ap-7-Deaza-dA
7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
-
GC65525
7-TFA-ap-7-Deaza-dG
5'-O-TBDMS-dG is a modified nucleoside.
-
GC90899
8-Aminoadenosine-5'-O-triphosphate (sodium salt)
An aminated derivative of ATP
-
GC90960
8-Bromo-2'-deoxyadenosine-5'-O-triphosphate (sodium salt)
A dATP derivative
-
GC46744
8-Bromoadenosine 5′-triphosphate (sodium salt hydrate)
8-bromo ATP
A neuropeptide with diverse biological activities -
GC12777
8-Chloroadenosine
Nucleoside analog, inhibits RNA synthesis
-
GC90841
8-Chloroadenosine-5'-triphosphate (sodium salt)
An active metabolite of 8-chloro cAMP
-
GC42627
8-Hydroxyguanine (hydrochloride)
NSC 22720, 8Oxoguanine
8-Hydroxyguanine is produced by oxidative degradation of DNA by hydroxyl radical. -
GC18426
8-Nitroguanine
8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.
-
GC41643
9(Z),11(E),13(E)-Octadecatrienoic Acid
αEleostearic Acid, αESA, LAF 237
9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. -
GC73399
9-(β-D-Xylofuranosyl)adenine
9-(β-D-Xylofuranosyl)adenine is an adenosine analog.
-
GC11903
9-amino Camptothecin
NSC 603071
9-amino Camptothecin (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity. -
GC45367
9-Hydroxyellipticine (hydrochloride)
9-OH-Ellipticine, NSC 210717
-
GN10035
9-Methoxycamptothecin
-
GC48840
9-Methoxyellipticine
Methoxy-9-ellipticine, NSC 69187
An alkaloid with anticancer activity -
GC60037
A-3 hydrochloride
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.
-
GC91113
A011
An inhibitor of ATM kinase
-
GC13805
Abacavir
-
GC63728
Abemaciclib metabolite M18 hydrochloride
LSN3106729 hydrochloride
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib, is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader. -
GC38749
Abemaciclib metabolite M20
LSN3106726
Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer. -
GC35218
Abemaciclib Metabolites M2
LSN2839567
Abemaciclib Metabolites M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity. -
GC64280
Abemaciclib-d8
LY2835219-d8
Abemaciclib-d8 (LY2835219-d8) is the deuterium labeled Abemaciclib. Abemaciclib (LY2835219) is a selective CDK4/6 inhibitor with IC50 values of 2 nM and 10 nM for CDK4 and CDK6, respectively. -
GC17418
AbK
H-L-Photo-lysine
AbK (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. -
GC74178
Ac-Exatecan
Ac-Exatecan is acetylated Exatecan.
-
GA20605
Ac-Lys-AMC
Ac-Lys-AMC is cleaved by trypsin.
-
GC61763
Ac-rC Phosphoramidite
Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
-
GC34090
Acelarin (NUC-1031)
Acelarin (NUC-1031) (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.
-
GC35238
Aclacinomycin A hydrochloride
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors.
-
GC49804
Acridine
2,3,5,6-Dibenzopyridine, 10-Azaanthracene, Dibenzopyridine, NSC 3408
An azaarene -
GC16866
Actinomycin D
Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K
Actinomycin D (dactinomycin) is a natural chromopeptide isolated from Streptomyces species, and has one heterocyclic chromophore and two cyclic pentapeptide lactone rings. [1] -
GC35247
ACX-362E
ACX-362E; GLS-362E
ACX-362E (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. -
GC34458
ACY-1083
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.
-
GC10417
ACY-241
Citarinostat
ACY-241 (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). ACY-241 has anticancer effects. -
GC19020
ACY-738
ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.
-
GC30782
ACY-775
An HDAC6 inhibitor
-
GC30526
ACY-957
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
-
GC17186
Acyclovir
ACV, BW 248U, NSC 645011
Acyclovir is a potent oral antiviral drug. Acyclovir has anti-herpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle disruption and apoptosis. -
GC13432
Adenine
High affinity adenine receptor agonist
-
GC11825
Adenine HCl
Adenine HCl (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine HCl acts as a chemical component of DNA and RNA. Adenine HCl also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
-
GC17278
Adenine sulfate
Adenine sulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine sulfate acts as a chemical component of DNA and RNA. Adenine sulfate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
-
GC68624
Adenine-13C
Adenine-8-C13; 9H-Purin-6-amine-8-13C
Adenine-13C is a 13C-labeled Adenine. Adenine (6-Aminopurine) is a purine and one of the four nucleobases in DNA. Adenine is a chemical component of both DNA and RNA. It plays an important role in cellular respiration, the formation of ATP, coenzymes NAD and FAD, as well as protein synthesis.
-
GC67946
Adenine-d1
6-Aminopurine-d1; Vitamin B4-d1
-
GC14106
Adenosine
NSC 7652
nucleoside -
GC49004
Adenosine 3’-monophosphate (sodium salt hydrate)
3’-AMP
A nucleotide -
GC42732
Adenosine 3',5'-diphosphate (sodium salt)
Adenosine 3',5'-bisphosphate, 3',5'-ADP, 3′-Phosphoadenosine 5′-phosphate
Adenosine 3',5'-diphosphate (sodium salt) is an hydroxysteroid sulfotransferases inhibitor. -
GC90794
Adenosine 5'-methylenediphosphate (sodium salt)
An inhibitor of ecto-5’-nucleotidase
-
GC65462
Adenosine 5′-monophosphoramidate sodium
Adenosine 5′-monophosphoramidate sodium is an adenosine derivative and can be used as an intermediate for nucleotide synthesis.
-
GC49285
Adenosine 5’-methylenediphosphate (hydrate)
Adenosine 5'-(α,β-methylene)diphosphate, AMP-CP, APCP, 5'-APCP
An inhibitor of ecto-5’-nucleotidase -
GC46806
Adenosine 5'-diphosphate (potassium salt hydrate)
5'-ADP, ADP
A neuropeptide with diverse biological activities -
GC42733
Adenosine 5'-monophosphate (sodium salt hydrate)
5’-AMP, AMP
Adenosine 5'-monophosphate (AMP) is a central nucleotide with functions in metabolism and cell signaling. -
GC42734
Adenosine 5'-phosphosulfate (sodium salt)
Adenosine 5'-phosphosulfate is an ATP and sulfate competitive inhibitor of ATP sulfurylase in humans, S. cerevisiae, and P. chrysogenum (Ki = 18, 2500, and 1500 nM, respectively).
-
GC68625
Adenosine-d2
Adenine riboside-d2; D-Adenosine-d2
Adenosine-d2 is the deuterated form of adenosine. Adenosine (adenine riboside) is a commonly occurring endogenous secretion that acts through four G protein-coupled receptors (A1, A2A, A2B, and A3). Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
-
GC49231
Adenylosuccinic Acid (ammonium salt)
A purine nucleotide and an intermediate in the purine nucleotide cycle
-
GC65330
AES-135
AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM.
-
GC46810
Aflatoxin B1-13C17
AFB1-13C17
An internal standard for the quantification of aflatoxin B1 -
GC46814
Aflatoxin M1-13C17
AFM1-13C17
A neuropeptide with diverse biological activities -
GC62470
AG-636
AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects.
-
GC71063
Akt1&PKA-IN-1
Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively.
-
GC42765
Aldehyde Reactive Probe (trifluoroacetate salt)
ARP, O(Biotinylcarbazoylmethyl) Hydroxylamine
DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. -
GC14858
Aldoxorubicin
INNO-206;Doxorubicin-EMCH;INNO 206
An albumin-binding prodrug of doxorubicin -
GC73642
ALK-IN-26
ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase.
-
GC73524
Alpha-Adenosine
Alpha-Adenosine is a purine nucleoside analog.
-
GC73525
Alpha-Guanosine
Alpha-Guanosine is a purine nucleoside analog.
-
GC15841
Alsterpaullone
9-Nitropaullone,NSC 705701
CDKs and GSK3β inhibitor -
GC67984
Alteminostat
CKD-581
-
GC10779
Alternariol
AOH,NSC 638263
A mycotoxin with antifungal and phytotoxic activity
-
GC18437
Alternariol monomethyl ether
AME, NSC 638262
Alternariol monomethyl ether, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species. -
GC49039
Althiomycin
NSC 102809
A thiazole antibiotic -
GC14564
Altretamine
2,4,6-Tris(dimethylamino)-1,3,5-triazine, Hexamethylmelamine, HMM, NSC 13875
Antineoplastic agent -
GC35310
Altretamine hydrochloride
ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride
Altretamine hydrochloride is an alkylating antineoplastic agent. -
GC64638
ALV1
ALV1 is a potent Ikaros and Helios degrader.
-
GC64818
AMA-37
AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively.
-
GC70420
Amelparib
Amelparib is a potent, orally active, and water-soluble inhibitor of PARP-1.
-
GC70421
Amelparib hydrochloride
Amelparib (JPI-289) hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1.
-
GC42783
Ametantrone
NSC 196473, NSC 290813
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break. -
GC50366
AMG 18 hydrochloride
AMG-18 Hydrochloride
AMG 18 hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. -
GC14899
AMG 548
P38α inhibitor,potent and selective
-
GC14974
AMG 925
FLT3/CDK4 inhibitor,potent and selective
-
GC35315
AMG 925 HCl
AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively.
-
GC91790
AMG PERK 44 (hydrochloride)
AMG PERK 44 is a protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 6 nM).
-
GC38518
AMG-548 dihydrochloride
AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ.
-
GC42789
Aminopterin
4-amino Folic Acid, 4-amino PGA, APGA, NSC 739
Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. -
GC11019
Amonafide
AS1413, Benzisoquinolinedione, Nafidimide, NCI 308847, NSC 308847
DNA intercalator,Topo II inhibitor -
GC15644
Amrubicin
SM-5887
A synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic. -
GC12326
Amsacrine
Topoisomerase 2 inhibitor
-
GC11747
Amsacrine hydrochloride
AMSA, m-AMSA, NSC 141549
Topoisomerase 2 inhibitor -
GC39284
ANI-7
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI50 of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines.
-
GC11559
Anisomycin
Flagecidin, NSC 76712, Wuningmeisu C
Anisomycin, an antibiotic isolated from Streptomyces griseus, is also a JNK activator.