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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair

Products for  DNA Damage/DNA Repair

  1. Cat.No. Product Name Information
  2. GC68667 Anticancer agent 73

    Anticancer agent 73 (compound CIB-3b) is an anticancer drug that targets TAR RNA binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 has inhibitory effects on the proliferation and metastasis of hepatocellular carcinoma (HCC) cells both in vitro and in vivo.

     Anticancer agent 73 Chemical Structure
  3. GC40032 Antipain (hydrochloride) Antipain (hydrochloride) is a protease inhibitor isolated from Actinomycetes. Antipain (hydrochloride) Chemical Structure
  4. GC68448 AOH1160 AOH1160 Chemical Structure
  5. GC91176 AOH1996

    An inhibitor of PCNA

     AOH1996 Chemical Structure
  6. GC67876 APE1-IN-1 APE1-IN-1 Chemical Structure
  7. GC17139 APY29 IRE1α inhibitor APY29 Chemical Structure
  8. GC45385 Ara-G

    ara-Guanosine, Guanine Arabinoside, NSC 76352

       Ara-G Chemical Structure
  9. GC72841 Arabinosylhypoxanthine Arabinosylpoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine Chemical Structure
  10. GC62425 ARN-21934 ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etoposide (IC50=120 μM). ARN-21934 exhibits a favorable in vivo pharmacokinetic profile and is a promising lead compound for anticancer research. ARN-21934 Chemical Structure
  11. GC46880 ARN24139 A topoisomerase II poison ARN24139 Chemical Structure
  12. GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19 AS2863619 Chemical Structure
  13. GC38737 AS2863619 free base AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base Chemical Structure
  14. GC38463 ASLAN003

    ASLAN003

     ASLAN003 (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice. ASLAN003 Chemical Structure
  15. GC61821 AT-130 AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 Chemical Structure
  16. GC15870 AT7519 Multi-CDK inhibitor AT7519 Chemical Structure
  17. GC13998 AT7519 Hydrochloride A Cdk inhibitor AT7519 Hydrochloride Chemical Structure
  18. GC15597 AT7519 trifluoroacetate AT7519 trifluoroacetate Chemical Structure
  19. GC65327 ATM Inhibitor-5

    M4076; ATM Inhibitor-5

     ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1). ATM Inhibitor-5 Chemical Structure
  20. GC65514 ATR inhibitor 1

    M1774; ATR inhibitor 1

     ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ. ATR inhibitor 1 Chemical Structure
  21. GC74316 ATR kinase substrate peptide ATR kinase substrate peptide (compound 45) is a potent and selective inhibitor of ATR (Ataxia Telangiectasia and Rad3 related) protein kinase (Ki=6 nM). ATR kinase substrate peptide Chemical Structure
  22. GC68707 ATR-IN-4

    ATR-IN-4 is an effective ATR inhibitor. ATR-IN-4 inhibits the growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460, with IC50 values of 130.9 nM and 41.33 nM, respectively (excerpted from patent CN112142744A, compound 13).

     ATR-IN-4 Chemical Structure
  23. GC34422 Atuveciclib (BAY-1143572) Atuveciclib (BAY-1143572) Chemical Structure
  24. GC34059 Atuveciclib Racemate (BAY-1143572 Racemate)

    BAY-1143572 Racemate

     Atuveciclib Racemate (BAY-1143572 Racemate) (BAY-1143572 Racemate) is the racemate mixture of Atuveciclib. Atuveciclib is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM. Atuveciclib Racemate (BAY-1143572 Racemate) Chemical Structure
  25. GC34421 Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) Chemical Structure
  26. GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid Chemical Structure
  27. GC46895 Aurintricarboxylic Acid (ammonium salt)

    ATA

     A protein synthesis inhibitor with diverse biological activities Aurintricarboxylic Acid (ammonium salt) Chemical Structure
  28. GC40005 Aurodox

    1-methyl-Mocimycin

    Aurodox is a polyketide antibiotic originally isolated from S.

     Aurodox Chemical Structure
  29. GC60062 AV-153 free base AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity. AV-153 free base Chemical Structure
  30. GC67960 AVG-233 AVG-233 Chemical Structure
  31. GC63449 Avotaciclib

    BEY1107

     Avotaciclib (BEY1107) is a potent and orally active inhibitor of cyclin dependent kinase 1 (CDK1). Avotaciclib can be used for the research of locally advanced or metastatic pancreatic cancer. Avotaciclib Chemical Structure
  32. GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable AZ 5704 Chemical Structure
  33. GC14949 AZ20

    AZ-20;AZ 20

     A potent, selective ATR inhibitor AZ20 Chemical Structure
  34. GC19047 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 uM for ATM in cell. AZ32 Chemical Structure
  35. GC65899 AZ3391 AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23). AZ3391 Chemical Structure
  36. GC68712 AZ5576

    AZ5576 is a potent and highly selective inhibitor of CDK9 (IC50: <5 nM). It can be used for research on hematologic malignancies.

     AZ5576 Chemical Structure
  37. GC16725 AZ6102 TNKS1/2 inhibitor AZ6102 Chemical Structure
  38. GC46900 AZ9482 A PARP inhibitor AZ9482 Chemical Structure
  39. GC11843 Azaguanine-8

    8-AG

     Azaguanine-8 is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth. Azaguanine-8 Chemical Structure
  40. GC15033 Azathioprine

    Azamune, Azoran, BW 57322, Imuran, NSC 39084

     purine synthesis and GTP-binding protein Rac1 activation inhibitor Azathioprine Chemical Structure
  41. GC50119 AZD 7762 hydrochloride Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing AZD 7762 hydrochloride Chemical Structure
  42. GC12438 AZD-5438

    AZD 5438;AZD5438

     Potent CDK1/2/9 inhibitor AZD-5438 Chemical Structure
  43. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648 Chemical Structure
  44. GC73919 AZD-9574-acid AZD-9574-acid (70D), a PPAR-1 inhibitor, can be used for the synthesis of PROTAC (CAS 2923686-70-6). AZD-9574-acid Chemical Structure
  45. GC11593 AZD0156 ATM kinase inhibitor AZD0156 Chemical Structure
  46. GC19468 AZD1390

    AZD1390 is a potent and selective ATM inhibitor

     AZD1390 Chemical Structure
  47. GC32717 AZD4573 AZD4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM) that enables transient target engagement for the treatment of hematologic malignancies. AZD4573 Chemical Structure
  48. GC16941 AZD6738

    Ceralasertib

     AZD6738 (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM. AZD6738 Chemical Structure
  49. GC10546 AZD7762 Checkpoint kinase inhibitor,ATP competitive AZD7762 Chemical Structure
  50. GC73787 AZD8421 AZD8421 is a selective CDK2 inhibitor (IC50: 9 nM) with selectivity for CDK1, CDK4 and CDK6. AZD8421 Chemical Structure
  51. GC60616 AZT triphosphate

    3'-Azido-3'-deoxythymidine-5'-triphosphate

     AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate Chemical Structure
  52. GC60617 AZT triphosphate TEA

    3'-Azido-3'-deoxythymidine-5'-triphosphate TEA

     AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA Chemical Structure
  53. GC33406 B I09 B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. B I09 Chemical Structure
  54. GC45820 Balsalazide-d4 A neuropeptide with diverse biological activities Balsalazide-d4 Chemical Structure
  55. GC33240 Banoxantrone D12 (AQ4N D12)

    AQ4N D12

     Banoxantrone D12 (AQ4N D12) is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone D12 (AQ4N D12) Chemical Structure
  56. GC34169 Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride)

    AQ4N-d12 dihydrochloride

     Banoxantrone-d12 (AQ4N-d12) dihydrochloride is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride) Chemical Structure
  57. GC34085 Banoxantrone dihydrochloride (AQ4N dihydrochloride)

    AQ4N dihydrochloride

     Banoxantrone dihydrochloride (AQ4N dihydrochloride) is an oxygen-depleted activated topoisomerase II inhibitor, AQ4N binds to DNA in a non-covalent manner and promotes antitumor activity of hypoxic and hypoxic tumor cells. Banoxantrone dihydrochloride (AQ4N dihydrochloride) Chemical Structure
  58. GC73130 Basroparib

    STP1002

     Basroparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity. Basroparib Chemical Structure
  59. GC13035 Bay 11-7821

    BAY 11-7082

     Bay 11-7821(BAY 11-7082) is an inhibitor of IκBα phosphorylation and NF-κB, selectively and irreversibly inhibits TNF-α-induced IκB-α phosphorylation (IC50 value is approximately 10μM), and reduces the expression of NF-κB and adhesion molecules. Bay 11-7821 inhibits ubiquitin-specific proteases USP7 and USP21 with IC50 values of 0.19 and 0.96μM, respectively . Bay 11-7821 Chemical Structure
  60. GC50656 BAY 707 BAY 707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY 707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy. BAY 707 Chemical Structure
  61. GC33420 BAY-1895344

    Elimusertib

     BAY-1895344 (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. BAY-1895344 has anti-tumor activity. BAY-1895344 can be used for the research of solid tumors and lymphomas. BAY-1895344 Chemical Structure
  62. GC34374 BAY-1895344 hydrochloride An ATR inhibitor BAY-1895344 hydrochloride Chemical Structure
  63. GC32838 BAY-2402234 A DHODH inhibitor BAY-2402234 Chemical Structure
  64. GC68740 BAY-728

    BAY-728 can be used as a negative control for BAY-805. BAY-805 is an effective selective inhibitor of USP21.

     BAY-728 Chemical Structure
  65. GC68742 BAY-805

    BAY-805 is a selective inhibitor of the ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases, and other common off-target enzymes.

     BAY-805 Chemical Structure
  66. GC63763 BAY-8400 BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer. BAY-8400 Chemical Structure
  67. GC65259 BC-1471 BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 Chemical Structure
  68. GC50572 BC-LI-0186 Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor BC-LI-0186 Chemical Structure
  69. GC62863 BCH001 BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 Chemical Structure
  70. GC32333 Beaucage reagent Beaucage reagent is found to be potent in causing DNA cleavage. Beaucage reagent Chemical Structure
  71. GC42912 Becatecarin

    BMS 181176, BMY 27557, NSC 655649, XL 119

     Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. Becatecarin Chemical Structure
  72. GC33066 Belotecan hydrochloride (CKD-602)

    7-2-(N-isopropylamino)ethyl-(20S)-Camptothecin, CKD602, (S)-CKD602

     Belotecan hydrochloride (CKD-602) (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. Belotecan hydrochloride (CKD-602) Chemical Structure
  73. GC64354 Bendamustine Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties. Bendamustine Chemical Structure
  74. GC34305 Bendamustine D4 (SDX-105 D4) Bendamustine D4 (SDX-105 D4) Chemical Structure
  75. GC10744 Bendamustine HCl

    SDX-105

     Bendamustine HCl (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine HCl activats DNA-damage stress response and apoptosis. Bendamustine HCl has potent alkylating, anticancer and antimetabolite properties. Bendamustine HCl Chemical Structure
  76. GC46914 Bendamustine-d4 (hydrochloride) A neuropeptide with diverse biological activities Bendamustine-d4 (hydrochloride) Chemical Structure
  77. GC49781 Benomyl

    NSC 263489

     A carbamate pesticide Benomyl Chemical Structure
  78. GC12844 Benzamide poly (ADP-ribose) synthetase inhibitor Benzamide Chemical Structure
  79. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

    4PBA

     Benzenebutyric acid (4-Phenylbutyric acid) (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Benzenebutyric acid (4-Phenylbutyric acid) Chemical Structure
  80. GN10221 Berberine

    Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.

     Berberine Chemical Structure
  81. GC35497 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties. Berberine chloride hydrate Chemical Structure
  82. GN10208 Berberine hydrochloride

    BBR, Umbellatine, NSC 163088, NSC 646666

     Berberine hydrochloride is a bioactive alkaloid of the isoquinoline class derived from the medicinal plant Coptis chinensis of the Ranunculaceae family, possessing a wide range of pharmacological functions with applications in cancer, inflammation, diabetes, depression, hypertension, and various infections. Berberine hydrochloride Chemical Structure
  83. GN10523 Berberine Sulfate Berberine Sulfate Chemical Structure
  84. GC10734 Beta-Lapachone

    ARQ 501, NSC 26326, NSC 629749, SL 11001

     Beta-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression. Beta-Lapachone Chemical Structure
  85. GC10480 Betulinic acid

    Lupatic Acid, NSC 113090

     Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC50 value of 5 μM. Betulinic acid Chemical Structure
  86. GC12074 BG45 Novel HDAC3-selective inhibitor BG45 Chemical Structure
  87. GC19067 BGG463

    K03859

     BGG463 is a CDK2 inhibitor. BGG463 Chemical Structure
  88. GC14380 BGP-15 PARP inhibitor BGP-15 Chemical Structure
  89. GC35512 BI-1347 BI-1347 is an orally active, selective and potent CDK8 inhibitor (IC50=1.1 nM). BI-1347 shows anti-tumoral activity. BI-1347 Chemical Structure
  90. GC13636 BIBR 1532

    Telomerase Inhibitor X

     Telomerase inhibitor,novel and selective BIBR 1532 Chemical Structure
  91. GC62653 bio-THZ1 bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. bio-THZ1 Chemical Structure
  92. GC74226 Biotin-PEG3-benzophenone Biotin-PEG3-benzophenone is biotin-labeled Benzophenone. Biotin-PEG3-benzophenone Chemical Structure
  93. GC25139 Biphenyl-4-sulfonyl chloride

    p-Phenylbenzenesulfonyl chloride, 4-Phenylbenzenesulfonyl chloride, p-Biphenylsulfonyl chloride

     Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Biphenyl-4-sulfonyl chloride Chemical Structure
  94. GC19073 Bisantrene Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. Bisantrene Chemical Structure
  95. GC68772 Bisantrene dihydrochloride

    CL-216942 dihydrochloride

    Bisantrene dihydrochloride is an effective anticancer agent that exerts cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets the topoisomerase II of eukaryotes. Bisantrene dihydrochloride is a substrate for MDR1.

     Bisantrene dihydrochloride Chemical Structure
  96. GC18354 Bisindolylmaleimide X (hydrochloride)

    BIM X, Ro 31-8425

     Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). Bisindolylmaleimide X (hydrochloride) Chemical Structure
  97. GC18094 Blasticidin S HCl

    Blasticidin S HCl is a nucleoside antibiotic isolated from Streptomyces griseochromogenes[1].

     Blasticidin S HCl Chemical Structure
  98. GC60089 Bleomycin hydrochloride Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic. Bleomycin hydrochloride Chemical Structure
  99. GC15819 Bleomycin Sulfate

    Blenoxane;Bleo;Blexane

     Bleomycin is produced by Streptomyces verticillis. Bleomycin Sulfate Chemical Structure
  100. GC73893 BLU-222 BLU-222 is an orally active and highly selective CDK2 inhibitor. BLU-222 Chemical Structure
  101. GC15190 BMH-21 RNA polymerase I Inhibitior BMH-21 Chemical Structure

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