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Checkpoint Kinase (Chk)

<div class="colum_1 clearer"><p>Checkpoint Kinases (Chk) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, embryo development, cellular responses to HIV infection and somatic cell viability. Chk2 is a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor.</p></div>

Targets for  Checkpoint Kinase (Chk)

Products for  Checkpoint Kinase (Chk)

  1. Cat.No. Product Name Information
  2. GC39284 ANI-7 ANI-7  Chemical Structure
  3. GC50119 AZD 7762 hydrochloride Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing AZD 7762 hydrochloride  Chemical Structure
  4. GC10546 AZD7762 Checkpoint kinase inhibitor,ATP competitive AZD7762  Chemical Structure
  5. GC11648 BML-277 Chk2 inhibitor,potent and highly selective BML-277  Chemical Structure
  6. GC50085 CCT 241533 dihydrochloride Potent Chk2 inhibitor CCT 241533 dihydrochloride  Chemical Structure
  7. GC18053 CCT241533 Potent Chk2 inhibitor CCT241533  Chemical Structure
  8. GC14772 CCT244747 Potent and selective CHK1 inhibitor CCT244747  Chemical Structure
  9. GC19093 CCT245737 CCT245737 is a orally active and seletive Chk1 inhibitor, with an IC50 of 1.3 nM. CCT245737  Chemical Structure
  10. GC15739 CHIR-124 Chk1 inhibitor,novel and potent CHIR-124  Chemical Structure
  11. GC33392 CHK-IN-1 CHK-IN-1  Chemical Structure
  12. GC30106 CHK1 inhibitor CHK1 inhibitor  Chemical Structure
  13. GC33289 CHK1-IN-2 CHK1-IN-2  Chemical Structure
  14. GC60698 Chk1-IN-5 Chk1-IN-5  Chemical Structure
  15. GC62986 GDC-0425 GDC-0425  Chemical Structure
  16. GC32885 GDC-0575 (ARRY-575, RG7741) GDC-0575 (ARRY-575, RG7741)  Chemical Structure
  17. GC34127 GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) GDC-0575 dihydrochloride (ARRY-575 dihydrochloride)  Chemical Structure
  18. GC15741 LY2603618 Chk1 inhibitor,highly selective LY2603618  Chemical Structure
  19. GC15663 LY2606368 CHK1 inhibitor LY2606368  Chemical Structure
  20. GC16374 MK-8776(SCH-900776) Chk1 inhibitor,potent and selective MK-8776(SCH-900776)  Chemical Structure
  21. GC38216 PD 407824 PD 407824  Chemical Structure
  22. GC18396 PD 407824

    PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively).

    PD 407824  Chemical Structure
  23. GC14234 PF-477736 Chk1 inhibitor PF-477736  Chemical Structure
  24. GC36966 Prexasertib dihydrochloride Prexasertib dihydrochloride  Chemical Structure
  25. GC36967 Prexasertib Mesylate Hydrate Prexasertib Mesylate Hydrate  Chemical Structure
  26. GC11022 SB 218078 checkpoint kinase 1 (Chk1) inhibitor SB 218078  Chemical Structure

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