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Home >> Signaling Pathways >> DNA Damage/DNA Repair >> Eukaryotic Initiation Factor (eIF)

Eukaryotic Initiation Factor (eIF)

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of the functional ribosome around the start codon and also provide regulatory mechanisms in translation initiation.

Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, thus regenerating the active [eIF2.GTP] complex that is required for peptide-chain initiation. The activity of eIF2B is a key control point for eukaryotic protein synthesis and is altered in response to viral infection, hormones, nutrients, growth factors and certain stresses.

Eukaryotic translation initiation factor 4E (eIF4E) is best known for its function in the initiation of protein synthesis on capped mRNAs in the cytoplasm. Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome.

Targets for  Eukaryotic Initiation Factor (eIF)

Products for  Eukaryotic Initiation Factor (eIF)

  1. Cat.No. Product Name Information
  2. GC39842 (Z)-4EGI-1 (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity. (Z)-4EGI-1 Chemical Structure
  3. GC13104 4E1RCat

    eIF4E/eIF4G Interaction Inhibitor II

     Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 4E1RCat Chemical Structure
  4. GC30785 4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 4E2RCat Chemical Structure
  5. GC10468 4EGI-1

    eIF4E/eIF4G Interaction Inhibitor

     Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1 Chemical Structure
  6. GC19083 Briciclib

    ON-014185

     Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. Briciclib Chemical Structure
  7. GC62698 CMLD012612 CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012612 inhibits cell translation and is cytotoxic to NIH/3T3 cells with an IC50 value of 2 nM. CMLD012612 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A) and possesses potent anti-neoplastic activity. CMLD012612 Chemical Structure
  8. GC39808 Didesmethylrocaglamide Didesmethylrocaglamide, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity. Didesmethylrocaglamide Chemical Structure
  9. GC71091 DNL343 DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 Chemical Structure
  10. GC73118 EB1 EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 Chemical Structure
  11. GC69046 EIF2α activator 1

    EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2α (eIF2α) phosphorylation. EIF2α activator 1 increases the expression levels of downstream proteins ATF and CHOP. EIF2α activator 1 has anti-proliferative activity against K562 and PBMC cells, with IC50 values of 4.00 and 19.3 μM, respectively.

     EIF2α activator 1 Chemical Structure
  12. GC69047 EIF2α activator 2

    EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2α (eIF2α) phosphorylation. In SRB cell proliferation assays, the IC50 is 0.46 μM. EIF2α activator 2 also exhibits anti-proliferative activity against K562 and PBMC cells with IC50 values of 4.79 and 10.52 μM, respectively.

     EIF2α activator 2 Chemical Structure
  13. GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD. eIF4A3-IN-1 Chemical Structure
  14. GC73171 eIF4A3-IN-12

    eIF4A3-IN-12 (compound 62) is a silvestrol analogue.

     eIF4A3-IN-12 Chemical Structure
  15. GC69048 eIF4A3-IN-14

    eIF4A3-IN-14 (compound 51) is a silvestrol analog. It interferes with the assembly of the eIF4F translation complex and has EC50 values of 40 and 50 nM for inhibiting myc-LUC expression and MBA-MB-231 cell growth, respectively. eIF4A3-IN-14 can be used for studying the mechanisms underlying human tumor development.

     eIF4A3-IN-14 Chemical Structure
  16. GC73172 eIF4A3-IN-16

    eIF4A3-IN-16 (compound 60) is a silvestrol analogue.

     eIF4A3-IN-16 Chemical Structure
  17. GC69049 eIF4A3-IN-18

    eIF4A3-IN-18 (compound 72) is a silvestrol analog. It interferes with the assembly of eIF4F translation complex and has EC50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and inhibition of MBA-MB-231 cell growth respectively. eIF4A3-IN-18 exhibits cytotoxicity against RMPI-8226 cells with an LC50 value of 0.06 nM. It can be used for studying the mechanisms underlying human tumor development.

     eIF4A3-IN-18 Chemical Structure
  18. GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. eIF4A3-IN-2 Chemical Structure
  19. GC65234 eIF4A3-IN-8 4-Hydroxybenzyl alcohol is a phenolic compound widely distributed in various kinds of plants. Anti-inflammatory, anti-oxidant, anti-nociceptive activity. Neuroprotective effect. Inhibitor of tumor angiogenesis and growth. eIF4A3-IN-8 Chemical Structure
  20. GC73170 eIF4A3-IN-9

    eIF4A3-IN-9 (compound 57) is a silvestrol analogue.

     eIF4A3-IN-9 Chemical Structure
  21. GC35998 Episilvestrol Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol Chemical Structure
  22. GC32739 GCN2iB GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. GCN2iB Chemical Structure
  23. GC62639 rel-Zotatifin

    rel-eFT226

     rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A?inhibitor with activity less than Zotatifin. rel-Zotatifin Chemical Structure
  24. GC19548 Rocaglamide

    Rocaglamide A; Roc-A

    Rocaglamide is a potent NF-κB activation inhibitor.

     Rocaglamide Chemical Structure
  25. GC33426 Rocaglamide (Rocaglamide A)

    Rocaglamide A; Roc-A

    Rocaglamide (Rocaglamide A) is isolated from the genus Aglaia (family Meliaceae). 

     Rocaglamide (Rocaglamide A) Chemical Structure
  26. GC69827 Rohinitib

    Rohinitib is an effective and specific inhibitor of eIF4A. Rohinitib induces apoptosis in acute myeloid leukemia (AML) cell lines and reduces the leukemia burden in AML xenograft mouse models. Rohinitib can be used for research on AML.

     Rohinitib Chemical Structure
  27. GC19451 SBI-0640756

    SBI-756

    SBI-0640756 is a water soluble inhibitor of eIF4G1 and disrupts the eIF4F complex

     SBI-0640756 Chemical Structure
  28. GC11455 Silvestrol Silvestrol Chemical Structure

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