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Nucleoside Antimetabolite/Analogue

Nucleoside analouges belong to the fmalily of antimetablits that resemble the neleosieds for uptake and metaolism that inibitr dna sytnse and couase cain termination. It is a durg target for cacner and viral infcations.

Products for  Nucleoside Antimetabolite/Analogue

  1. Cat.No. Product Name Information
  2. GC17904 Leflunomide AHR agonist,immunosuppressive agent Leflunomide  Chemical Structure
  3. GC17522 LY2334737 Anticancer agent LY2334737  Chemical Structure
  4. GC13704 Mercaptopurine (6-MP) Mercaptopurine (6-MP) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug. Mercaptopurine (6-MP)  Chemical Structure
  5. GC11222 Methylthioadenosine Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. Methylthioadenosine  Chemical Structure
  6. GC69589 N-Propargyladenosine

    N-Propargyladenosine is an adenosine analogue. Adenosine analogues are mostly used as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Some popular products in this series include Adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine.

    N-Propargyladenosine  Chemical Structure
  7. GC69525 N1-Methyl-2'-deoxyadenosine

    N1-Methyl-2'-deoxyadenosine, DNA adduct is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing cell apoptosis, etc.

    N1-Methyl-2'-deoxyadenosine  Chemical Structure
  8. GC66075 N1-Methylpseudouridine-5′-triphosphate trisodium N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability. N1-Methylpseudouridine-5′-triphosphate trisodium  Chemical Structure
  9. GC65127 N2-Methylguanosine N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's. N2-Methylguanosine  Chemical Structure
  10. GC36681 N6,N6-Dimethyladenosine N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Guérin tRNA. N6,N6-Dimethyladenosine  Chemical Structure
  11. GC65241 N6-Etheno 2'-deoxyadenosine N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues. N6-Etheno 2'-deoxyadenosine  Chemical Structure
  12. GC65561 N6-Methyl-dA phosphoramidite N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides. N6-Methyl-dA phosphoramidite  Chemical Structure
  13. GC10591 Nelarabine Prodrug of ara-G for T-LBL/T-ALL Nelarabine  Chemical Structure
  14. GC33956 Nucleoside-Analog-1 Nucleoside-Analog-1 is a 4′-Azidocytidine analogue against Hepatitis C virus replication. Nucleoside-Analog-1  Chemical Structure
  15. GC33959 Nucleoside-Analog-2 Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication. Nucleoside-Analog-2  Chemical Structure
  16. GC11528 Orotic acid Pyrimidinecarboxylic acid Orotic acid  Chemical Structure
  17. GC61168 Peldesine Peldesine (BCX 34) is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine  Chemical Structure
  18. GC61633 Peldesine dihydrochloride Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride  Chemical Structure
  19. GC17848 Penciclovir HSV-1 DNA synthesis inhibitor Penciclovir  Chemical Structure
  20. GC16514 Penciclovir Sodium antiviral drug Penciclovir Sodium  Chemical Structure
  21. GC33944 Pseudothymidine (5-Methyl-2'-Deoxypseudouridin) Pseudothymidine (5-Methyl-2'-Deoxypseudouridin) is a C-nucleoside analog of thymidine. Pseudothymidine (5-Methyl-2'-Deoxypseudouridin)  Chemical Structure
  22. GC17750 Raltitrexed

    Thymidylate synthase inhibitor

    Raltitrexed  Chemical Structure
  23. GC37577 RX-3117 RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis. RX-3117  Chemical Structure
  24. GC19319 Sapacitabine Sapacitabine is an orally available nucleoside analog prodrug that is structurally related to cytarabine. Sapacitabine  Chemical Structure
  25. GC19348 TAS-102 TAS-102 (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of TAS-102 (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). TAS-102 (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA. TAS-102  Chemical Structure
  26. GC64373 Tezacitabine Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment. Tezacitabine  Chemical Structure
  27. GC67477 Tiazofurin Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin  Chemical Structure
  28. GC37798 Tipiracil Tipiracil is a thymidine phosphorylase (TPase) inhibitor. Tipiracil  Chemical Structure
  29. GC14473 Tipiracil hydrochloride A potent TPase inhibitor Tipiracil hydrochloride  Chemical Structure
  30. GC61348 Triazavirin Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin  Chemical Structure
  31. GC13803 Triflurdine (Viroptic) Triflurdine (Viroptic) (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Triflurdine (Viroptic) is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity. Triflurdine (Viroptic)  Chemical Structure
  32. GC62546 Uridine triphosphate 13C9,15N2 sodium Uridine triphosphate 13C9,15N2 (UTP 13C9,15N2) sodium is a labeled Uridine triphosphate sodium. Uridine triphosphate 13C9,15N2 sodium  Chemical Structure
  33. GC70096 Uridine-13C

    Uridine-13C is a 13C-labeled Uridine. Uridine (β-Uridine) is a nucleoside compound composed of Uracil and Ribose, connected by a β-N1-glycosidic bond.

    Uridine-13C  Chemical Structure
  34. GC10082 Vidarabine antiviral drug for herpes viruses Vidarabine  Chemical Structure
  35. GC10637 Zidovudine Reverse transcriptase inhibitor Zidovudine  Chemical Structure

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