Nucleoside Antimetabolite/Analogue
Nucleoside analouges belong to the fmalily of antimetablits that resemble the neleosieds for uptake and metaolism that inibitr dna sytnse and couase cain termination. It is a durg target for cacner and viral infcations.
Products for Nucleoside Antimetabolite/Analogue
- Cat.No. Product Name Information
- GC17904 Leflunomide AHR agonist,immunosuppressive agent
- GC17522 LY2334737 Anticancer agent
- GC13704 Mercaptopurine (6-MP) Mercaptopurine (6-MP) is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.
- GC11222 Methylthioadenosine Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis.
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GC69589
N-Propargyladenosine
N-Propargyladenosine is an adenosine analogue. Adenosine analogues are mostly used as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Some popular products in this series include Adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine.
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GC69525
N1-Methyl-2'-deoxyadenosine
N1-Methyl-2'-deoxyadenosine, DNA adduct is a purine nucleoside analogue. Purine nucleoside analogues have broad anti-tumor activity and target inert lymphoid malignancies. The anticancer mechanism in this process depends on inhibiting DNA synthesis, inducing cell apoptosis, etc.
- GC66075 N1-Methylpseudouridine-5′-triphosphate trisodium N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) trisodium is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
- GC65127 N2-Methylguanosine N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.
- GC36681 N6,N6-Dimethyladenosine N6,N6-Dimethyladenosine is a modified ribonucleoside previously found in rRNA, and also exhibits in mycobacterium bovis Bacille Calmette-Guérin tRNA.
- GC65241 N6-Etheno 2'-deoxyadenosine N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.
- GC65561 N6-Methyl-dA phosphoramidite N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides.
- GC10591 Nelarabine Prodrug of ara-G for T-LBL/T-ALL
- GC33956 Nucleoside-Analog-1 Nucleoside-Analog-1 is a 4′-Azidocytidine analogue against Hepatitis C virus replication.
- GC33959 Nucleoside-Analog-2 Nucleoside-Analog-2 is a 4'-Azidocytidine analogue against Hepatitis C virus (HCV) replication.
- GC11528 Orotic acid Pyrimidinecarboxylic acid
- GC61168 Peldesine Peldesine (BCX 34) is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively.
- GC61633 Peldesine dihydrochloride Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively.
- GC17848 Penciclovir HSV-1 DNA synthesis inhibitor
- GC16514 Penciclovir Sodium antiviral drug
- GC33944 Pseudothymidine (5-Methyl-2'-Deoxypseudouridin) Pseudothymidine (5-Methyl-2'-Deoxypseudouridin) is a C-nucleoside analog of thymidine.
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GC17750
Raltitrexed
Thymidylate synthase inhibitor
- GC37577 RX-3117 RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis.
- GC19319 Sapacitabine Sapacitabine is an orally available nucleoside analog prodrug that is structurally related to cytarabine.
- GC19348 TAS-102 TAS-102 (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of TAS-102 (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). TAS-102 (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.
- GC64373 Tezacitabine Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment.
- GC67477 Tiazofurin Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin also has anti-orthopoxvirus and anti-variola activities.
- GC37798 Tipiracil Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
- GC14473 Tipiracil hydrochloride A potent TPase inhibitor
- GC61348 Triazavirin Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.
- GC13803 Triflurdine (Viroptic) Triflurdine (Viroptic) (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Triflurdine (Viroptic) is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity.
- GC62546 Uridine triphosphate 13C9,15N2 sodium Uridine triphosphate 13C9,15N2 (UTP 13C9,15N2) sodium is a labeled Uridine triphosphate sodium.
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GC70096
Uridine-13C
Uridine-13C is a 13C-labeled Uridine. Uridine (β-Uridine) is a nucleoside compound composed of Uracil and Ribose, connected by a β-N1-glycosidic bond.
- GC10082 Vidarabine antiviral drug for herpes viruses
- GC10637 Zidovudine Reverse transcriptase inhibitor