Topoisomerase
Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.
Products for Topoisomerase
- Cat.No. Product Name Information
- GC61531 PluriSIn #2 PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).
- GC33143 Podocarpusflavone A A biflavone with diverse biological activities
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GN10416
Podophyllotoxin
A lignan with diverse biological activities
- GC39425 Proscillaridin A Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.
- GC61224 Pyrazoloacridine Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment.
- GC44809 Rebeccamycin Rebeccamycin is an indolocarbazole antibiotic produced by S.
- GC18751 Reticulol Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 uM).
- GC67990 RPR121056
- GC37571 Rubitecan A DNA topoisomerase I inhibitor
- GN10449 SN-38 (NK012)
- GC49760 SN-38 Glucuronide
- GC64465 SN-38-d3 SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
- GC19342 SW044248 SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines.
- GC33127 TAS-103 (BMS-247615) TAS-103 (BMS-247615) is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
- GC32822 TAS-103 dihydrochloride (BMS-247615 dihydrochloride) TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
- GC45009 Temafloxacin Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor.
- GC16084 Teniposide Topoisomerase inhibitor
- GC11298 TH-302 A hypoxia-activated anticancer agent
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GC70044
Topoisomerase I inhibitor 8
Topoisomerase I inhibitor 8 is a potent inhibitor of topoisomerase I. It is a camptothecin analogue and has toxicity against tumor cells.
- GC17833 Topotecan Topoisomerase 1 inhibitor
- GC13359 Topotecan HCl Topotecan HCl (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
- GC45888 Topotecan-d6 An internal standard for the quantification of topotecan
- GC60374 Trovafloxacin Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms.
- GC12638 UK 1 inhibitor of topoisomerase II and hepatitis C viral replication
- GC49308 Ungeremine A betaine-type alkaloid with diverse biological activities
- GC13544 Voreloxin An inhibitor of topoisomerase II
- GC14022 Voreloxin Hydrochloride