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Topoisomerase

Topoisomerase are enzymes that regulate the overwinding or underwinding of DNA.

Products for  Topoisomerase

  1. Cat.No. Product Name Information
  2. GC61531 PluriSIn #2 PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs). PluriSIn #2  Chemical Structure
  3. GC33143 Podocarpusflavone A A biflavone with diverse biological activities Podocarpusflavone A  Chemical Structure
  4. GN10416 Podophyllotoxin

    A lignan with diverse biological activities

    Podophyllotoxin  Chemical Structure
  5. GC39425 Proscillaridin A Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively. Proscillaridin A  Chemical Structure
  6. GC61224 Pyrazoloacridine Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment. Pyrazoloacridine  Chemical Structure
  7. GC44809 Rebeccamycin Rebeccamycin is an indolocarbazole antibiotic produced by S. Rebeccamycin  Chemical Structure
  8. GC18751 Reticulol Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 uM). Reticulol  Chemical Structure
  9. GC67990 RPR121056 RPR121056  Chemical Structure
  10. GC37571 Rubitecan A DNA topoisomerase I inhibitor Rubitecan  Chemical Structure
  11. GN10449 SN-38 (NK012) SN-38 (NK012)  Chemical Structure
  12. GC49760 SN-38 Glucuronide SN-38 Glucuronide  Chemical Structure
  13. GC64465 SN-38-d3 SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38-d3  Chemical Structure
  14. GC19342 SW044248 SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines. SW044248  Chemical Structure
  15. GC33127 TAS-103 (BMS-247615) TAS-103 (BMS-247615) is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 (BMS-247615)  Chemical Structure
  16. GC32822 TAS-103 dihydrochloride (BMS-247615 dihydrochloride) TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 dihydrochloride (BMS-247615 dihydrochloride)  Chemical Structure
  17. GC45009 Temafloxacin Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. Temafloxacin  Chemical Structure
  18. GC16084 Teniposide Topoisomerase inhibitor Teniposide  Chemical Structure
  19. GC11298 TH-302 A hypoxia-activated anticancer agent TH-302  Chemical Structure
  20. GC70044 Topoisomerase I inhibitor 8

    Topoisomerase I inhibitor 8 is a potent inhibitor of topoisomerase I. It is a camptothecin analogue and has toxicity against tumor cells.

    Topoisomerase I inhibitor 8  Chemical Structure
  21. GC17833 Topotecan Topoisomerase 1 inhibitor Topotecan  Chemical Structure
  22. GC13359 Topotecan HCl Topotecan HCl (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities. Topotecan HCl  Chemical Structure
  23. GC45888 Topotecan-d6 An internal standard for the quantification of topotecan Topotecan-d6  Chemical Structure
  24. GC60374 Trovafloxacin Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin  Chemical Structure
  25. GC12638 UK 1 inhibitor of topoisomerase II and hepatitis C viral replication UK 1  Chemical Structure
  26. GC49308 Ungeremine A betaine-type alkaloid with diverse biological activities Ungeremine  Chemical Structure
  27. GC13544 Voreloxin An inhibitor of topoisomerase II Voreloxin  Chemical Structure
  28. GC14022 Voreloxin Hydrochloride Voreloxin Hydrochloride  Chemical Structure

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