Endocrinology and Hormones
Endocrinology and Hormones
The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more
Targets for Endocrinology and Hormones
- 5-alpha Reductase(8)
- Smoothened Receptors(3)
- Androgen Receptor(137)
- Aromatase(13)
- CRTH2(2)
- Estrogen/progestogen Receptor(147)
- GnRH(26)
- Opioid Receptor(175)
- RAAS(8)
- Thyroid hormone Receptor(59)
- TRH(2)
- ROR/RAR/RXR(94)
- FXR & LXR(69)
- Glucocorticoids & Mineralocorticoids(49)
- GPR(1)
Products for Endocrinology and Hormones
- Cat.No. Product Name Information
- GC49326 5β-Dihydroprogesterone A progesterone receptor agonist and metabolite of progesterone
- GC49176 5β-Tetrahydrocortisol An endogenous metabolite of cortisol
- GC46075 5,6-dimethyl-2-Thiouracil A heterocyclic building block
- GC49827 5-Androstenetriol An active metabolite of DHEA
- GC15774 5α-dihydro-11-keto Testosterone 5α-dihydro-11-keto Testosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione.
- GC49676 6β-hydroxy Budesonide A metabolite of budesonide
- GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone
- GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone
- GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs).
- GC18335 6β-hydroxy Dexamethasone 6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound.
- GC49206 7α-hydroxy Dehydroepiandrosterone An active metabolite of dehydroepiandrosterone
- GC49391 7α-Thiospironolactone An active metabolite of spironolactone
- GC46740 7β,27-dihydroxy Cholesterol An oxysterol and agonist of RORγ and RORγt
- GC63764 7-α-Methylthio Spironolactone-D3
- GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine
- GC48880 7-Methoxyflavone A flavone with diverse biological activities
- GC17119 8-Prenylnaringenin estrogen receptor inhibitor
- GC40464 9(R)-HETE 9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE.
- GC40465 9(S)-HETE 9(S)-HETE is an enantiomer which makes up 50% of (±)9-HETE.
- GC14596 9-cis-Retinoic Acid 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist.
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GP10060
a-MSH, amide
a-MSH (α-Melanocyte-Stimulating Hormone), amide engages the melanocortin-1 receptor and activates cyclic AMP (cAMP) signaling via a G-protein transporter, can synthesize melanin.
- GC46768 Abaloparatide (acetate) A synthetic derivative of PTHrP and an agonist of PTHR1
- GC38581 Abaloparatide TFA Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue selected to be a potent and selective activator of the PTHR1 signaling pathway.
- GC45778 Abarelix (acetate) A synthetic GnRHR antagonist
- GC32843 Abarelix (R3827) Abarelix (R3827) (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
- GC35217 Abarelix Acetate Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.
- GC50091 AC 186 Potent and selective ERβ agonist; neuroprotective
- GC11852 AC 261066 Potent RARβ2 agonist
- GC10871 AC 55649 RARβ2 agonist, potent and selective
- GC46777 AC-262536 A selective androgen receptor modulator
- GP10059 Acetyl Angiotensinogen (1-14), porcine
- GC17059 Acetyl Podocarpic Acid Anhydride LXR agonist
- GC64147 Acetyl tetrapeptide-15 Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin.
-
GC17094
Acitretin
Metabolite of etretinate
- GC17113 Acitretin sodium Second-generation, systemic retinoid
- GC31738 ACP-105 ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.
- GC31530 ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human) ACTH 4-11 (Adrenocorticotropic Hormone (4-11), human), an adrenocorticotropin hormone fragment, possesses a weak α-melanocyte stimulating hormone (α-MSH) potency only at high doses (100 and 1000 nM).
- GC10610 Adapalene RARβ and RARγ agonist
- GC14379 Adapalene sodium salt Retinoic acid receptor agonist
- GC46798 Adapalene-d3 An internal standard for the quantification of adapalene
- GC13959 Adarotene An atypical retinoid
- GC11829 ADL5859 HCl ADL5859 HCl (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an Ki and an EC50 value of 0.84 and 20 nM, respectively.
- GC67703 Adrenocorticotropic hormone TFA
- GC42741 Adrenomedullin (22-52) (human) (trifluoroacetate salt) Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52).
- GP10109 Adrenorphin
- GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.
- GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.
- GC12598 AGN 194310 pan-RAR antagonist
- GC35265 AGN 195183 AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ.
- GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).
- GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR.
- GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
- GC39584 AGN194204 AGN194204 (IRX4204) is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively.
- GC31742 Ailanthone (δ13-Dehydrochaparrinone) Ailanthone (δ13-Dehydrochaparrinone) (δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309nM).
- GC12374 Alarelin Acetate A peptide agonist of GnRH
-
GC46827
Aldosterone 21-sulfate (sodium salt)
A metabolite of aldosterone
- GC14511 all-trans Retinal converted to retinoic acid in vivo
- GC42769 all-trans Retinoyl β-D-Glucuronide all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system.
- GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid
- GC18482 all-trans-5,6-epoxy Retinoic Acid all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s = 77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively).
-
GC40024
Altenusin
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.
- GC13297 Altrenogest Progestogen receptor agonist
- GC17623 Alvimopan A μ-opioid receptor antagonist
- GC12619 Alvimopan dihydrate A μ-opioid receptor antagonist
- GC35311 Alvimopan monohydrate Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM.
- GC13664 AM580 Selective RARα agonist
- GC16433 Aminoglutethimide Aromatase inhibitor
- GC63932 Amsilarotene Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer.
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GC10256
Anastrozole
Aromatase inhibitor
- GC46854 Anastrozole-d12 An internal standard for the quantification of anastrozole
- GC13685 Andarine Andarine (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. Andarine (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.
- GC67698 Androgen receptor-IN-2
- GC31254 Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- (Androst-4-ene-3β,17β-diol, dipropionate)
- GC34887 Androstanolone acetate
-
GC30842
Androsterone (5α-Androstan-3α-ol-17-one)
An androgenic steroid
- GP10074 Angiotensin 1/2 (1-5)
- GP10067 Angiotensin 1/2 (1-6)
- GP10144 Angiotensin 1/2 (1-7) amide
-
GP10012
Angiotensin 1/2 (1-8) amide
Vasoconstrictor
- GP10025 Angiotensin 1/2 (1-9)
-
GP10045
Angiotensin 1/2 (2-7)
Vasoconstrictor
- GP10079 Angiotensin 1/2 (5-7)
- GP10120 Angiotensin 1/2 + A (2 - 8) Vasoconstrictor
- GC52415 Angiotensin A (trifluoroacetate salt) An AT1 and AT2 receptor agonist and active metabolite of angiotensin II
- GP10087 Angiotensin I (human, mouse, rat)
-
GC46856
Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)
An endogenous angiotensin II fragment
- GC42815 Ansatrienin A Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S.
- GC46859 Antide (acetate) A GnRHR antagonist
- GC60589 Apalutamide D4 Apalutamide D4 (ARN-509 D4) is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
- GC12219 AR-M 1000390 hydrochloride Delta-opioid receptor agonist,low-internalizing
- GC64540 Ar-V7-IN-1 Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43).
- GC19035 AR7 A retinoic acid receptor α (RARα) antagonist
- GC42852 Arginine Vasotocin (trifluoroacetate salt) Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X.
- GC16840 ARN-509 ARN-509 (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
- GC62118 ARV-110 ARV-110 (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer.
- GC10547 ASC-J9 A selective enhancer of AR degradation
- GC31762 Asimadoline (EMD-61753) Asimadoline (EMD-61753) (EMD-61753) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).
- GC61397 Asimadoline hydrochloride Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant).
- GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid
- GC66207 Atraric acid Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.