Endocrinology and Hormones

Endocrinology and Hormones
The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more
Targets for Endocrinology and Hormones
- 5-alpha Reductase(8)
- Smoothened Receptors(3)
- Androgen Receptor(154)
- Aromatase(12)
- CRTH2(2)
- Estrogen/progestogen Receptor(163)
- GnRH(28)
- Opioid Receptor(176)
- RAAS(7)
- Thyroid hormone Receptor(66)
- TRH(1)
- ROR/RAR/RXR(95)
- FXR & LXR(84)
- Glucocorticoids & Mineralocorticoids(69)
- GPR(1)
- Androgen/Estrogen Receptor Modulators(1)
Products for Endocrinology and Hormones
- Cat.No. Product Name Information
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GC65260
EDP-305
EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells).
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GC19135
Elagolix
Elagolix is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM).
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GC19136
Elagolix sodium
Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
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GC67956
Endomorphin 1 acetate
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GC35986
Endomorphin 2 TFA
Endomorphin 2 TFA, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.
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GP10065
Endomorphin-1
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GC10059
Endomorphin-2
μ-opioid receptors agonist
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GC12140
Endoxifen
Endoxifen Z-isomer is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).
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GC49648
Enobosarm-d4
(S)-Enobosarm-d4
An internal standard for the quantification of enobosarm -
GC64854
Enzalutamide-d3
Enzalutamide D3 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.
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GC69072
Enzalutamide-d6
MDV3100-d6
Enzalutamide-d6 is a deuterium-labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cancer cells.
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GC16631
EPI-001
AR antagonist
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GC73291
EPI-7170
EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs).
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GC13072
Epiandrosterone
5α-Androstan-3β-ol-17-one, Isoandrosterone, trans-Androsterone, NSC 93996
steroid hormone with weak androgenic activity -
GC32953
Epristeride (ONO-9302)
Epristeride (ONO-9302) (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. Epristeride (ONO-9302) has inhibitory effects for SR isoenzymes types 2 with Ki value of 0.7-2 nM. Epristeride (ONO-9302) can be used for the research of prostatic hyperplasia and acne.
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GC33764
Eprotirome (KB2115)
Eprotirome
Eprotirome (KB2115) (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. -
GC18333
Equilenin
(+)-Equilenin, d-Equilenin, NSC 9901
Equilenin is an equine estrogen found in the urine of pregnant mares. -
GC16292
Equol
non-steroidal estrogen
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GC12577
ER 50891
RARα receptor antagonist
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GC72808
ER 50891 quarterhydrate
ER 50891 quarterdrate is a potent antagonist of retinoic acid receptor α(RARα).
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GC10389
ERB 041
ERB 041 (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. ERB 041 displays >200-fold selectivity for ERβ over ERα. ERB 041 is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. ERB 041 induces ovarian cancer apoptosis.
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GC11822
Erteberel (LY500307)
LY500307
Erteberel (LY500307) (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist with Ki and EC50 of 1.54 nM and 3.61 nM, respectively. -
GC47309
Estetrol (hydrate)
E4, 15α-Hydroxyestriol
A naturally occurring estrogen -
GC48979
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
E217G, βEstradiol 17(βDGlucuronide), 17βEstradiol 17(βDGlucuronide), 17βOestradiol 17(βDGlucuronide)
A substrate of multidrug resistance protein 2 -
GC43629
Estradiol 3-sulfate 17β-Glucuronide (potassium salt)
Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol, and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma.
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GC10139
Estradiol Cypionate
Estradiol 17β-Cyclopentanepropionate, Estradiol 17-Cypionate, NSC 3354
Estrogen receptor inhibitor -
GC11796
Estradiol valerate
Estradiol 17β-valerate, NSC 17590
Estradiol valerate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs. -
GC12182
Estriol
E3, 16α-hydroxy-17β-Estradiol, 1,3,5(10)-Estratriene-3,16α,17β-triol
Estrogen receptor antagonist -
GC43630
Estriol 3-β-D-Glucuronide (sodium salt)
Estriol sodium 3-glucuronate
Estriol 3-β-D-glucuronide is a metabolite of estriol. -
GC45450
Estriol-d2
E3-d2, 16αhydroxy17βEstradiol-d2, 1,3,5(10)Estratriene3,16α,17βtriol-d2
Estriol-d2 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. -
GC14385
Estrone
E1
Estrone is one of the three major endogenous estrogens, the others being estradiol and estriol. -
GC45451
Estrone 3-methyl ether
(+)-Estrone methyl ether, 3-O-methyl Estrone, NSC 88911
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GC49254
Estrone-3-Glucuronide (sodium salt hydrate)
E1G, Estrone Glucuronide, Estrone β-D-Glucuronide
A metabolite of 17β-estradiol -
GC45452
Estrone-d2
E1-d2
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GC16852
Estropipate
Piperazine Estrone Sulfate
Estrogen receptor agonist -
GC12148
Ethinyl Estradiol
Ethynyl βEstradiol, Ethynyl 17βEstradiol, Ethynyl 17βOestradiol, Ethynyl E2
Ethinyl Estradiol (17α-Ethynylestradiol;Ethynylestradiol) is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. -
GC11436
Ethisterone
Progestogen hormone
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GC12000
Ethynodiol diacetate
SC-11800
Progestogen receptor agonist -
GC47320
Ethynyl Estradiol 3-β-D-Glucuronide (hydrate)
17α-Ethynylestradiol 3-Glucuronide
A metabolite of ethynyl estradiol -
GC13303
Etonogestrel
ORG 3236, 3-keto Desogestrel, 3-oxo Desogestrel
steroidal progestin -
GC32451
Examorelin (Hexarelin)
Examorelin, H-2-Me-WAWFK, His-2-Me-Trp-Ala-Trp-Phe-Lys-NH2, His-(D)-Mrp-Ala-Trp-(D)-Phe-Lys-NH2
A peptide agonist of GHS-R -
GC11813
Exemestane
Aromasin, FCE 24304
Steroidal aromatase inhibitor,selective and irreversible -
GC63755
Exemestane-D2
FCE 24304-D2; EXE-D2
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GC19151
Fadrozole
Fadrozole (CGS 16949A) is a selective, non-steroidal aromatase inhibitor with an IC50 value of 4.5μM.
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GC18301
Fadrozole (hydrochloride)
CGS 16949A
Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively). -
GC25410
Fasiglifam (TAK-875)
Fasiglifam (TAK-875) is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.
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GC49563
Fenhexamid
KBR 2738
Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. -
GC17143
Fenretinide
4-HPR, 4-Hydroxy(phenyl)retinamide, MK-4016, Retinoic Acid p-hydroxyphenylamide, Ro 22-4667
A synthetic retinoic acid derivative -
GC50190
Fenretinide - d4
4-HPR-d4, 4-Hydroxy(phenyl)retinamide-d4, Retinoic Acid p-hydroxyphenylamide-d4
Fenretinide - d4 is the deuterium labeled Fenretinide. -
GC14131
FERb 033
ERβ receptor agonist
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GC18641
Ferutinin
Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) α (IC50 = 33.1 nM) and an agonist/antagonist for ERβ (IC50 = 180.5 nM).
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GC10755
Fexaramine
farnesoid X receptor agonist
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GC16248
Finasteride
MK-906
Inhibitor of Type II 5α-reductase -
GC17572
Finasteride acetate
5α-reductase inhibitor
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GC60842
Finerenone
BAY 94-8862
Finerenone (BAY 94-8862) is a third-generation selective, orally active, nonsteroidal mineralocorticoid receptor (MR) antagonist with an IC50 of 18 nM. -
GC15874
FIT
δ-opioid agonist, irreversible
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GC38682
Flavanone
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase).
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GC47361
Fludioxonil
CGA 173506
A fungicide -
GC49631
Fluocortolone
SH 742
A glucocorticoid -
GC11694
Fluorobexarotene
RXR agonist
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GC10618
Fluoxymesterone
NSC 10704, NSC 12165
androgen receptor agonist -
GC10064
Flurizan
E7869, Flurizan, Tarenflurbil
A COX-inactive enantiomer of flurbiprofen -
GC12126
Flutamide
Niftolide, NSC 147834, NSC 251876, SCH 13521
Androgen receptor antagonists -
GC48831
Flutamide-d7
SCH 13521-d7
An internal standard for the quantification of flutamide -
GC45455
Fluticasone 17β-Carboxylic Acid
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GC12815
Formestane
CGP 32349, Formestane, 4-HAD, 4-Hydroxy-androst-4-ene-3,17-dione, Lentaron, NSC 282175
Type I steroidal aromatase inhibitor -
GC60857
Frakefamide TFA
Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist.
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GC72225
Fsh receptor-binding inhibitor fragment(bi-10)
FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist.
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GC18000
Fulvestrant (ICI 182,780)
ICI 182780
Fulvestrant is a selective estrogen receptor (ER) antagonist. It binds, blocks and degrades estrogen receptor, then inhibits estrogen receptor(ER)-mediated transcriptional activity with an IC50 of 9.4 nM . -
GC49878
Fulvestrant 9-sulfone
An estrogen receptor antagonist and a derivative of fulvestrant
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GC40241
Fulvestrant-d3
ICI 182780-d3; ZD 9238-d3; ZM 182780-d3
Fulvestrant-d3 is intended for use as an internal standard for the quantification of fulvestrant by GC- or LC-MS. -
GC90891
Furosine (hydrochloride)
An L-lysine derivative
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GC71185
FXR agonist 3
FXR agonist 3 is an anti-NASH agent, acting by activating FXR.
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GC69138
FXR agonist 5
FXR agonist 5 (compound 1) is a type of FXR activator. FXR agonist 5 can be used to study diseases or disorders caused by metabolic inflammation.
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GC71156
FXR antagonist 1
FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM).
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GC12766
G-1
G-1 is a selective and potent agonist of GPR30 with EC50 value about 2 nM.
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GC16618
G-15
A GPER receptor antagonist
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GC14902
G-36
GPER activator
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GC74031
GA32
GA32 (compound 58r) is potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively.
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GC43736
Ganirelix (acetate)
Ganirelix is a gonadotropin-releasing hormone receptor (GNRHR) antagonist (IC50 = 3.6 nM; pA2 = 9.3).
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GC49303
Ganoderic Acid DM
A triterpenoid with diverse biological activities
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GC10017
Gestodene
Progestogen hormonal contraceptive
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GC48763
Gestodene-d6
SHB 331-d6; WL 70-d6
An internal standard for the quantification of gestodene -
GC52506
Ghrelin (human) (trifluoroacetate salt)
Lenomorelin
A growth hormone releasing peptide -
GC43752
Ghrelin (rat) (acetyl) (trifluoroacetate salt)
Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).
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GC43753
Ghrelin (rat) (palmitoyl) (trifluoroacetate salt)
Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).
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GC43754
Ghrelin (rat) (trifluoroacetate salt)
Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).
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GC45803
GHRP-2 (trifluoroacetate salt)
D-Ala-3-(2-naphthalenyl)-D-Ala-L-Ala-L-Trp-D-Phe-L-lysinamide, Growth Hormone-Releasing Peptide 2, KP-102, Pralmorelin
A neuropeptide with diverse biological activities -
GC45459
GHRP-6 (acetate)
Growth Hormone Releasing Peptide 6, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E
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GC45462
GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
Glucagon-like Peptide 1 (1-36) amide (human, rat)
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GC43763
GLP-1 (7-37) (human, bovine, guinea pig, mouse, rat) (trifluoroacetate salt)
Glucagon-like Peptide-1 (7-37) (human, bovine, guinea pig, mouse, rat)
Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine. -
GC45463
GLP-2 (1-34) (human) (trifluoroacetate salt)
Glucagon-like Peptide 2 (1-34)
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GC43764
GLP-2 (human) (trifluoroacetate salt)
Glucagon-like Peptide-2
Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion. -
GC45464
GLP-2 (rat) (trifluoroacetate salt)
Glucagon-like Peptide 2
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GC30086
GLPG0492
A selective androgen receptor modulator
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GC30101
GLPG0492 R enantiomer
GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator.
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GP10122
Glucagon (19-29), human
H2N-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
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GC52490
Glucagon (hydrochloride)
A peptide hormone
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GC49342
Glucagon-d9 (trifluoroacetate salt)
An internal standard for the quantification of glucagon
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GC40049
Glucocorticoid Resistance Inhibitor
Glucocorticoid resistance inhibitor is an inhibitor of glucocorticoid resistance.