Androgen Receptor
AR (androgen receptor) is a member of steroid hormone receptor and ligand-activated transcription factor. It plays a crucial role in prostate cellular proliferation and male sexual differentiation.
Products for Androgen Receptor
- Cat.No. Product Name Information
- GC45239 δ4-Abiraterone δ4-Abiraterone is a major metabolite of abiraterone. δ4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.
- GC61491 (R)-Bicalutamide (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.
- GC30710 (R)-UT-155 (R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer.
- GC63292 (rac)-PF-998425 (Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist.
-
GC49520
(S)-Equol
An estrogen receptor β agonist
- GC46456 16α-Hydroxyetiocholanolone A metabolite of 16α-DHEA and androstenedione
- GC17557 17 alpha-propionate A peripherally selective androgen receptor antagonist
- GC41300 17β-hydroxy Exemestane 17β-hydroxy Exemestane is the primary active metabolite of exemestane.
- GC35069 2,2,5,7,8-Pentamethyl-6-Chromanol 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
- GC17160 2-hydroxy Flutamide 2-hydroxy Flutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). 2-hydroxy Flutamide can be used for the research of prostate cancer.
- GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects
- GC49542 5α-Androstan-3β-ol A steroidal androgen
- GC48808 5β-Androstane-3α,17β-diol A metabolite of testosterone
- GC49827 5-Androstenetriol An active metabolite of DHEA
- GC15774 5α-dihydro-11-keto Testosterone 5α-dihydro-11-keto Testosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione.
- GC49391 7α-Thiospironolactone An active metabolite of spironolactone
- GC63764 7-α-Methylthio Spironolactone-D3
- GC48880 7-Methoxyflavone A flavone with diverse biological activities
- GC46777 AC-262536 A selective androgen receptor modulator
- GC31738 ACP-105 ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.
- GC67703 Adrenocorticotropic hormone TFA
- GC31742 Ailanthone (δ13-Dehydrochaparrinone) Ailanthone (δ13-Dehydrochaparrinone) (δ13-Dehydrochaparrinone) is a potent inhibitor of both full-length androgen receptor (AR) (IC50=69nM) and constitutively active truncated AR splice variants (AR1-651 IC50=309nM).
- GC13685 Andarine Andarine (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. Andarine (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.
- GC67698 Androgen receptor-IN-2
- GC31254 Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- (Androst-4-ene-3β,17β-diol, dipropionate)
- GC34887 Androstanolone acetate
- GC60589 Apalutamide D4 Apalutamide D4 (ARN-509 D4) is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
- GC64540 Ar-V7-IN-1 Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43).
- GC16840 ARN-509 ARN-509 (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
- GC62118 ARV-110 ARV-110 (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer.
- GC10547 ASC-J9 A selective enhancer of AR degradation
- GC66207 Atraric acid Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.
- GC10372 AZD3514 Androgen receptor downregulator
- GC12271 Bicalutamide Androgen receptor antagonist
- GC46925 Bicalutamide-d4 An internal standard for the quantification of bicalutamide
- GC31577 Bifluranol (BX341) Bifluranol (BX341) (BX341) is an anti-androgen.
- GC35534 BMS-564929 BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM.
- GC41187 Boldenone Cypionate Boldenone is an anabolic androgenic steroid and synthetic derivative of testosterone that was originally developed for veterinary use.
- GC35541 Boldenone Undecylenate
-
GC17491
CITCO
Constitutive androstane receptor (CAR) agonist
- GC14560 Cl-4AS-1 steroidal androgen receptor agonist
- GC62209 CLP-3094 CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR).
- GC47159 Cyprodinil An anilinopyrimidine fungicide
- GC13971 Cyproterone Acetate Androgen receptor antagonist
- GC10785 Danazol A derivative of testosterone and ethisterone
- GC11070 Dehydroepiandrosterone (DHEA) Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, together represent the most abundant steroid hormones in the human body .
- GC34005 Dehydroisoandrosterone 3-acetate (Dehydroepiandrosterone 3-acetate) Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.
- GC47215 Dienogest-d8 An internal standard for the quantification of dienogest
- GC47231 Dimethomorph A morpholine fungicide
- GC31441 DJ-V-159 DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).
- GC49648 Enobosarm-d4 An internal standard for the quantification of enobosarm
- GC64854 Enzalutamide-d3 Enzalutamide D3 is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.
- GC16631 EPI-001 AR antagonist
- GC13072 Epiandrosterone steroid hormone with weak androgenic activity
- GC11796 Estradiol valerate Estradiol valerate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs.
- GC49563 Fenhexamid Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor.
- GC10618 Fluoxymesterone androgen receptor agonist
- GC12126 Flutamide Androgen receptor antagonists
- GC48831 Flutamide-d7 An internal standard for the quantification of flutamide
- GC49303 Ganoderic Acid DM A triterpenoid with diverse biological activities
- GC30086 GLPG0492 A selective androgen receptor modulator
- GC30101 GLPG0492 R enantiomer GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator.
- GC17679 GSK2881078 selective androgen receptor modulator (SARM)
- GC14221 HE-3235 HE-3235, synthetic analogue of 3β-androstanediol, is an orally bioavailable anticancer agent. HE-3235 is active in rodent models of prostate and breast cancer.
- GC62249 Honokiol DCA
- GC36344 Isosilybin B Isosilybin B, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation.
- GC62106 JNJ-63576253 JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).
- GC18496 Leelamine (hydrochloride) Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means 'play'- It has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 uM.
- GC47554 Letrozole-d4 An internal standard for the quantification of letrozole
-
GC32403
LGD-3303
LGD-3303 is a selective androgen receptor modulator (SARM).
- GC32408 LGD-4033 An Analytical Reference Standard
- GC63579 Linuron Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards.
- GN10142 Lupeol
-
GC31380
LY2452473
LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM).
-
GC12385
MDV3100 (Enzalutamide)
A non-steroidal androgen receptor antagonist
-
GC12974
Medroxyprogesterone acetate
Steroidal progestin
- GC61850 Medroxyprogesterone acetate D3
- GC63066 Methenolone acetate
- GC11837 MI-136 menin-MLL interaction inhibitor
- GC36621 MK-0773 MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.
- GC32907 N-desmethyl Enzalutamide (N-desmethyl MDV 3100) N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide (N-desmethyl MDV 3100) demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.
- GC64586 Nandrolone laurate
- GC63096 Nandrolone phenylpropionate
- GC44363 Neoaureothin Neoaureothin is a bacterial metabolite that has been found in Streptomyces.
- GC44405 Nilutamide Nilutamide is a non-steroidal antiandrogen that is an antagonist of the androgen receptor.
- GC11386 ODM-201 ODM-201 (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay.
- GC32402 ORM-15341 ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.
- GC36820 Ostarine
- GC44527 p,p'-DDE p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.
- GC12938 PF 998425 non-steroidal androgen receptor (AR) antagonist
- GC48724 Pregnanetriol A metabolite of 17α-hydroxyprogesterone
- GC44686 Prochloraz Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.
- GC36981 PROTAC AR Degrader-4
- GC61481 PROTAC AR Degrader-4 TFA
- GC33224 Proxalutamide (GT0918) Proxalutamide (GT0918) (GT0918) is an orally active potent androgen receptor (AR) antagonist. Proxalutamide (GT0918) (GT0918) can be used in the study for prostate cancer and COVID-19.
- GC19305 RAD140 RAD140 (RAD140) is a potent, orally active, nonsteroidal selective androgen receptor modulator (SARM) with a Ki of 7 nM.
- GC62683 Ralaniten Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC50 of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC).
- GC62603 Ralaniten triacetate Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7.
-
GC11957
RD162
androgen receptor (AR) antagonist
- GC63402 Rezvilutamide Rezvilutamide (SHR3680) is an androgen receptor antagonist. Rezvilutamide (SHR3680) is used for the study of prostate cancer.