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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics

Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Targets for  Chromatin/Epigenetics

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. GC14434 BYK 49187 Potent PARP-1/PARP-2 inhibitor BYK 49187 Chemical Structure
  3. GC16130 C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor C 21 Chemical Structure
  4. GC17011 C2 Ceramide

    C2 Ceramide (d18:1/2:0)， C2 Ceramide ，Ceramide (d18:1/2:0)， Cer(18:1/2:0)，N-acetoyl-D-erythro-sphingosine

     A cell-permeable analog of naturally occurring ceramides C2 Ceramide Chemical Structure
  5. GC12733 C646 C646, a potent and selective p300/CBP histone acetyltransferase inhibitor (Ki 400 nM), has been shown to have pleiotropic activity, including neuroprotective, anti-cancer and anti-epithelial-mesenchymal transition (anti-EMT) effects. C646 Chemical Structure
  6. GC12005 C7280948 Novel PRMT1 inhibitor C7280948 Chemical Structure
  7. GC62886 Cannabisin F Cannabisin F Chemical Structure
  8. GC12082 Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor Cantharidic Acid (sodium salt) Chemical Structure
  9. GC73615 CARM1 degrader-1 hydrochloride CARM1 degrader-1 drochloride is the drochloride salt form of CARM1 degrader-1. CARM1 degrader-1 hydrochloride Chemical Structure
  10. GC34108 CARM1-IN-1

    Protein Arginine Methyltransferase 4/CoactivatorAssociated Arginine Methyltransferase 1 Inhibitor

     A selective inhibitor of PRMT4/CARM1 CARM1-IN-1 Chemical Structure
  11. GC34424 CARM1-IN-1 hydrochloride CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). CARM1-IN-1 hydrochloride Chemical Structure
  12. GC73386 CARM1-IN-3 CARM1-IN-3 (compound 17b) is a potent and selective co-activator associated arginine metltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively. CARM1-IN-3 Chemical Structure
  13. GC73387 CARM1-IN-3 dihydrochloride CARM1-IN-3 didrochloride (compound 17b) is a potent and selective co-activator associated arginine metltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively. CARM1-IN-3 dihydrochloride Chemical Structure
  14. GC43147 CAY10398

    MD 85, PX 089274

     CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. CAY10398 Chemical Structure
  15. GC41601 CAY10591

    SIRT1 Activator 3, Sirtuin 1 Activator 3

     CAY10591 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. CAY10591 Chemical Structure
  16. GC18228 CAY10602 Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD-dependent protein deacetylase that has been implicated in cell metabolism, differentiation, stress and DNA damage response, and the control of multidrug resistance in cancer. CAY10602 Chemical Structure
  17. GC12971 CAY10603

    HDAC 6 inhibitor, Histone Deacetylase Inhibitor VIII

    potent and selective inhibitor of HDAC6

     CAY10603 Chemical Structure
  18. GC40767 CAY10669 CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid. CAY10669 Chemical Structure
  19. GC18949 CAY10677

    Icmt Inhibitor 15

     Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. CAY10677 Chemical Structure
  20. GC43192 CAY10685 CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety for use in click chemistry reactions. CAY10685 Chemical Structure
  21. GC43200 CAY10721 CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). CAY10721 Chemical Structure
  22. GC43201 CAY10722 CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). CAY10722 Chemical Structure
  23. GC43202 CAY10723

    AFM30a, AMF30a

     CAY10723 is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. CAY10723 Chemical Structure
  24. GC90710 CAY10723 (hydrochloride)

    A PAD2 inhibitor

     CAY10723 (hydrochloride) Chemical Structure
  25. GC47050 CAY10727 A PAD3 inhibitor CAY10727 Chemical Structure
  26. GC45402 CAY10729 (trifluoroacetate salt) (technical grade)   CAY10729 (trifluoroacetate salt) (technical grade) Chemical Structure
  27. GC47055 CAY10749 CAY10749 (compound 15) is a potent PARP/PI3K inhibitor with pIC50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. CAY10749 is a highly effective anticancer compound targeted against a wide range of oncologic diseases. CAY10749 Chemical Structure
  28. GC47056 CAY10753 A TNKS2 inhibitor CAY10753 Chemical Structure
  29. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs CAY17c Chemical Structure
  30. GC35621 CBB1003 CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. CBB1003 Chemical Structure
  31. GC35622 CBB1003 hydrochloride CBB1003 Hcl is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. CBB1003 hydrochloride Chemical Structure
  32. GC14151 CBB1007 LSD1 inhibitor,potent and selective CBB1007 Chemical Structure
  33. GC35623 CBB1007 hydrochloride CBB1007 Hcl is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). CBB1007 hydrochloride Chemical Structure
  34. GC35624 CBB1007 trihydrochloride CBB1007 trihydrochloride is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). CBB1007 trihydrochloride Chemical Structure
  35. GC14058 CBHA

    Histone Deacetylase Inhibitor II,m-Carboxycinnamic Acid bis-Hydroxamide

     CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis and suppresses tumor growth. CBHA Chemical Structure
  36. GC34517 CBP-IN-1

    CBP-IN-1

     CBP-IN-1 (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. CBP-IN-1 binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression. CBP-IN-1 Chemical Structure
  37. GC61577 CBP/p300-IN-1 CBP/p300-IN-1 is a CBP/EP300 bromodomain inhibitor. CBP/p300-IN-1 Chemical Structure
  38. GC68841 CBP/p300-IN-10

    CBP/p300-IN-10 is an efficient inhibitor of histone acetyltransferases EP300 and CREBBP, with IC50 values of 26 nM and 39 nM, respectively.

     CBP/p300-IN-10 Chemical Structure
  39. GC64696 CBP/p300-IN-12 CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450. CBP/p300-IN-12 Chemical Structure
  40. GC73365 CBP/p300-IN-20 CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 Chemical Structure
  41. GC38469 CBP/p300-IN-3 CBP/p300-IN-3, a p300/CBP histone acetyltransferase inhibitor, Compound 6, is sourced from patent WO 2019049061 A1. CBP/p300-IN-3 Chemical Structure
  42. GC62330 CC-90010

    BMS-986378, CC-90010

     CC-90010 (compound 1) is a reversible and orally active BET inhibitor. CC-90010 is applied in the study for advanced solid tumors. CC-90010 Chemical Structure
  43. GC12891 CCT007093 PPM1D inhibitor CCT007093 Chemical Structure
  44. GC11310 CCT129202 An Aurora kinase inhibitor CCT129202 Chemical Structure
  45. GC14566 CCT137690 An inhibitor of Aurora kinases and FLT3 CCT137690 Chemical Structure
  46. GC19092 CCT241736 CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM). CCT241736 Chemical Structure
  47. GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction CD532 Chemical Structure
  48. GC62189 CD532 hydrochloride CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer. CD532 hydrochloride Chemical Structure
  49. GC19098 CeMMEC1 CeMMEC1 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 uM for TAF1, and a Kd of 1.8 uM for TAF1 (2). CeMMEC1 Chemical Structure
  50. GC35651 Cenisertib

    AS-703569; R-763

     Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib Chemical Structure
  51. GC12083 CEP-33779 A potent, orally available inhibitor of JAK2 CEP-33779 Chemical Structure
  52. GC11209 Cerdulatinib (PRT062070)

    PRT062070, PRT2070

     Cerdulatinib (PRT062070) (PRT062070) is a selective Tyk2 inhibitor with an IC50 of 0.5 nM. Cerdulatinib (PRT062070) (PRT062070) also is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively. Cerdulatinib (PRT062070) Chemical Structure
  53. GC33028 CF53 CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo. CF53 Chemical Structure
  54. GC65602 CFT8634 CFT8634 is a degrader targeting BRD9 extracted from patent WO2021178920A1 compound 174. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors. CFT8634 Chemical Structure
  55. GC35668 CG-200745

    CG-200745

     CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745 Chemical Structure
  56. GC39679 CG347B CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. CG347B Chemical Structure
  57. GC14936 Chaetocin Chaetocin was reported to be a nonspecific inhibitor of histone methyl transferase (HMT) such as SUV39H1, thereby affecting gene expression. Chaetocin Chemical Structure
  58. GC11975 CHAPS CHAPS Chemical Structure
  59. GC64942 CHDI-390576 CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. CHDI-390576 Chemical Structure
  60. GC17405 Chetomin

    NSC 289491

     An inhibitor of HIF signaling Chetomin Chemical Structure
  61. GC62145 Chiauranib

    CS2164

     Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects. Chiauranib Chemical Structure
  62. GC64255 CHIC35 CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 ?M). CHIC35 Chemical Structure
  63. GC16042 Chidamide

    CS 055, HBI 8000, Tucidinostat

     Chidamide (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Chidamide Chemical Structure
  64. GN10518 Chitosamine hydrochloride

    D-(+)-Glucosamine, GlcN, NSC 234443, NSC 758

     Chitosamine hydrochloride Chemical Structure
  65. GC45717 Chlamydocin An HDAC inhibitor Chlamydocin Chemical Structure
  66. GN10308 Chlorogenic acid

    3OCaffeoylquinic acid, Heriguard, NSC 407296

     Chlorogenic acid is a potent neuroprotective agent and also has antiviral,antifungal antioxidant and antitumor properties. CGA is also involved in regulating glucose and lipid metabolism and improving insulin sensitivity. Chlorogenic acid Chemical Structure
  67. GC11652 CHZ868 Type II JAK2 inhibitor CHZ868 Chemical Structure
  68. GC11539 CI 976

    PD 128042

     CI 976 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. CI 976 Chemical Structure
  69. GC13408 CI994 (Tacedinaline)

    N-Acetyldinaline, Goe 5549, PD 123654, Tacedinaline

     An inhibitor of HDAC1, -2, and -3 CI994 (Tacedinaline) Chemical Structure
  70. GC15718 CID 2011756 An inhibitor of protein kinase D CID 2011756 Chemical Structure
  71. GC18577 CID-2818500

    α-Nitrostilbene, NSC 385

     An inhibitor of PRMT1 CID-2818500 Chemical Structure
  72. GC70438 cis-BG47 cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. cis-BG47 Chemical Structure
  73. GC72800 cis-MZ 1 hydrate cis-MZ 1 drate is a negative control for BRD4-targeted PROTAC MZ 1. cis-MZ 1 hydrate Chemical Structure
  74. GC52351 Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide

    Citrullinated Enolase-1-biotin, α-Enolase Peptide (Citrulline Residues 8 + 14)

     A biotinylated and citrullinated α-enolase peptide Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide Chemical Structure
  75. GC52363 Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide

    Biotin-A-Cit-TKQTA-Cit-KSTGGKAP-Cit-KQLA, Biotin-AXTKQTAXKSTGGKAPXKQLA (X=Citrulline), Citrullinated Histone H3.1-biotin

    A biotinylated and citrullinated histone H3 peptide

     Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide Chemical Structure
  76. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ, Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (G146R) (R144 + R146)-biotin

     A biotinylated and citrullinated mutant vimentin peptide Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide Chemical Structure
  77. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin

     A biotinylated and citrullinated vimentin peptide Citrullinated Vimentin (R144) (139-159)-biotin Peptide Chemical Structure
  78. GC40255 Citrulline-specific Probe-biotin

    Citrulline-specific probe-biotin is an affinity probe that allows for detection or immobilization of citrullinated proteins through interaction with the biotin ligand.

     Citrulline-specific Probe-biotin Chemical Structure
  79. GC43275 Citrulline-specific Probe-Rhodamine

    Rhodamine Phenylglyoxal, RhPG

     Protein arginine deiminases (PADs) catalyze the posttranslational modification of arginine residues on proteins to form citrulline, which plays a large role in regulating gene expression. Citrulline-specific Probe-Rhodamine Chemical Structure
  80. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8 CK2/ERK8-IN-1 Chemical Structure
  81. GC35706 Cl-amidine

    Cl-amidine (N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide), is a PAD4 inactivator with enhanced potency.

     Cl-amidine Chemical Structure
  82. GC18925 Cl-Amidine (hydrochloride) Cl-amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 uM for PAD1, PAD3, and PAD4 in vitro, respectively). Cl-Amidine (hydrochloride) Chemical Structure
  83. GC11032 Cl-Amidine (trifluoroacetate salt) Cl-Amidine (trifluoroacetate salt) is a multi-targeting peptidylarginine deminase (PAD) inhibitor with the functional group RC(NR)NR2 that inhibits PAD1 (IC50=0.8μM), PAD3 (IC50=6.2μM), and PAD4 (IC50=5.9μM) with 15min half-time. Cl-Amidine (trifluoroacetate salt) Chemical Structure
  84. GC73933 CM-1758 CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 Chemical Structure
  85. GC12367 CM-272 CM-272 is a first-in-class reversible dual inhibitor against G9a and DNMTs with IC50 values of 8 nM and 382 nM, respectively [1]. CM-272 Chemical Structure
  86. GC33320 CM-579 CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. CM-579 Chemical Structure
  87. GC35714 CM-579 trihydrochloride CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. CM-579 trihydrochloride Chemical Structure
  88. GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 Chemical Structure
  89. GC39665 CMP-5 CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected. CMP-5 Chemical Structure
  90. GC73027 Cobomarsen sodium

    MRG-106 sodium

     Cobomarsen sodium is an oligonucleotide inhibitor of miR-155. Cobomarsen sodium Chemical Structure
  91. GC34165 Corin Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. Corin Chemical Structure
  92. GC43318 coumarin-SAHA

    coumarin-Suberoylanilide Hydroxamic Acid

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

     coumarin-SAHA Chemical Structure
  93. GC62908 Coumermycin A1

    Coumermycin A1 is a JAK2 signal activator.

     Coumermycin A1 Chemical Structure
  94. GC25304 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. CP2 Chemical Structure
  95. GC16298 CPI-1205 EZH2 inhibitor CPI-1205 Chemical Structure
  96. GC62669 CPI-1612 CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity. CPI-1612 Chemical Structure
  97. GC16599 CPI-169 EZH2 inhibitor CPI-169 Chemical Structure
  98. GC14699 CPI-203 BET bromodomain inhibitor CPI-203 Chemical Structure
  99. GC43320 CPI-268456 CPI-268456 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 μM. CPI-268456 Chemical Structure
  100. GC10021 CPI-360 EZH2 inhibitor CPI-360 Chemical Structure
  101. GC10774 CPI-455

    KDM5 inhibitor

     CPI-455 Chemical Structure

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