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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Aurora Kinase

Aurora Kinase

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

Products for  Aurora Kinase

  1. Cat.No. Product Name Information
  2. GC35216 AAPK-25 AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM. AAPK-25 Chemical Structure
  3. GC62433 AKI603 AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells. AKI603 Chemical Structure
  4. GC13198 AMG-900 A selective pan-Aurora kinase inhibitor AMG-900 Chemical Structure
  5. GC10638 AT9283 A broad spectrum kinase inhibitor AT9283 Chemical Structure
  6. GC13332 Aurora A Inhibitor I A potent and selective inhibitor of Aurora A kinase Aurora A Inhibitor I Chemical Structure
  7. GC33379 Aurora B inhibitor 1 Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor extracted from patent WO2007059299A1, compound 1-3, has a Ki value of <0.010 uM. Aurora B inhibitor 1 Chemical Structure
  8. GC38441 Aurora Kinase Inhibitor 3 A potent inhibitor of Aurora A kinase Aurora Kinase Inhibitor 3 Chemical Structure
  9. GC40667 Aurora Kinase Inhibitor II Aurora Kinase Inhibitor II is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively. Aurora Kinase Inhibitor II Chemical Structure
  10. GC15711 Aurora Kinase Inhibitor III Aurora Kinase Inhibitor III is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora Kinase Inhibitor III Chemical Structure
  11. GC67899 Aurora kinase inhibitor-8 Aurora kinase inhibitor-8 Chemical Structure
  12. GC48971 AZD 1152 (hydrochloride) A prodrug for a potent Aurora B inhibitor AZD 1152 (hydrochloride) Chemical Structure
  13. GC14709 AZD1152 AZD1152 Chemical Structure
  14. GC14955 Barasertib (AZD1152-HQPA) A selective Aurora kinase B inhibitor Barasertib (AZD1152-HQPA) Chemical Structure
  15. GC17828 BI-847325 dual inhibitor of MEK and Aurora kinases BI-847325 Chemical Structure
  16. GC42933 Binucleine 2 Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. Binucleine 2 Chemical Structure
  17. GC11310 CCT129202 An Aurora kinase inhibitor CCT129202 Chemical Structure
  18. GC14566 CCT137690 An inhibitor of Aurora kinases and FLT3 CCT137690 Chemical Structure
  19. GC19092 CCT241736 CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM). CCT241736 Chemical Structure
  20. GC48982 CD532 An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction CD532 Chemical Structure
  21. GC62189 CD532 hydrochloride CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer. CD532 hydrochloride Chemical Structure
  22. GC35651 Cenisertib Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib Chemical Structure
  23. GC62145 Chiauranib Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects. Chiauranib Chemical Structure
  24. GC15106 CYC116 A potent Aurora kinase inhibitor CYC116 Chemical Structure
  25. GC15217 Danusertib (PHA-739358) A pan-Aurora kinase and Abl inhibitor Danusertib (PHA-739358) Chemical Structure
  26. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride Chemical Structure
  27. GC16519 ENMD-2076 A multi-kinase inhibitor ENMD-2076 Chemical Structure
  28. GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid Chemical Structure
  29. GC10008 GSK1070916 A potent inhibitor of Aurora B and C kinases GSK1070916 Chemical Structure
  30. GC17196 Hesperadin A multi-kinase inhibitor Hesperadin Chemical Structure
  31. GC50050 Hesperadin hydrochloride Potent Aurora kinase B inhibitor Hesperadin hydrochloride Chemical Structure
  32. GC34159 Ilorasertib (ABT-348) Ilorasertib (ABT-348) (ABT-348) is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib (ABT-348) also is a potent VEGF, PDGF inhibitor. Ilorasertib (ABT-348) has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Ilorasertib (ABT-348) Chemical Structure
  33. GC38519 Ilorasertib hydrochloride Ilorasertib (ABT-348) hydrochloride is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Ilorasertib hydrochloride Chemical Structure
  34. GC12612 JNJ-7706621 A dual inhibitor of CDKs and Aurora kinases JNJ-7706621 Chemical Structure
  35. GC14592 KW 2449 A multi-kinase inhibitor KW 2449 Chemical Structure
  36. GC33057 LY3295668 (AK-01) LY3295668 (AK-01) (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668 (AK-01) Chemical Structure
  37. GC17162 MK-5108 (VX-689) A potent inhibitor of Aurora kinases MK-5108 (VX-689) Chemical Structure
  38. GC10442 MK-8745 Aurora A inhibitor,potent and selective MK-8745 Chemical Structure
  39. GC12208 MLN8054 An inhibitor of Aurora A kinase MLN8054 Chemical Structure
  40. GC12690 MLN8237 (Alisertib)

    An Aurora A kinase inhibitor

     MLN8237 (Alisertib) Chemical Structure
  41. GC34692 NU6140 A Cdk2 inhibitor NU6140 Chemical Structure
  42. GC18074 PF-03814735 An inhibitor of Aurora A and B kinases PF-03814735 Chemical Structure
  43. GC10479 PHA-680632 An Aurora kinase inhibitor PHA-680632 Chemical Structure
  44. GC13668 Phthalazinone pyrazole Aurora A kinase inhibitor Phthalazinone pyrazole Chemical Structure
  45. GC14651 Reversine A purine derivative Reversine Chemical Structure
  46. GC16614 SCH-1473759 SCH-1473759 Chemical Structure
  47. GC37606 SCH-1473759 hydrochloride SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively. SCH-1473759 hydrochloride Chemical Structure
  48. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. SNS-314 Chemical Structure
  49. GC13837 SNS-314 Mesylate A pan-Aurora kinase inhibitor SNS-314 Mesylate Chemical Structure
  50. GC17455 TAK-632 A selective pan-Raf inhibitor TAK-632 Chemical Structure
  51. GC11085 TAK-901 A non-selective inhibitor of Aurora kinases TAK-901 Chemical Structure
  52. GC62482 TAS-119 TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites. TAS-119 Chemical Structure
  53. GC16378 TC-A 2317 hydrochloride Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). TC-A 2317 hydrochloride Chemical Structure
  54. GC70030 Tinengotinib

    Tinengotinib is a regulator of one or more protein kinases, such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential to study diseases mediated by these kinase abnormalities, especially cancer-related diseases (excerpt from patent WO2018108079A1).

     Tinengotinib Chemical Structure
  55. GC11549 VX-680 (MK-0457,Tozasertib) An Aurora kinase inhibitor that regulates mitosis VX-680 (MK-0457,Tozasertib) Chemical Structure
  56. GC13102 XL228 A tyrosine kinase inhibitor XL228 Chemical Structure
  57. GC14409 ZM 447439 Selective inhibitor of Aurora B kinase ZM 447439 Chemical Structure

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