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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Bromodomain

Bromodomain

Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.

Products for  Bromodomain

  1. Cat.No. Product Name Information
  2. GC13822 (-)-JQ1 A selective inhibitor of BET bromodomains (-)-JQ1 Chemical Structure
  3. GC46675 4-Phenyl-2-pyrrolidinone A precursor and synthetic intermediate 4-Phenyl-2-pyrrolidinone Chemical Structure
  4. GC13014 AZD 5153 orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4. AZD 5153 Chemical Structure
  5. GC15175 BAZ2-ICR Selective BAZ2 bromodomain inhibitor BAZ2-ICR Chemical Structure
  6. GC16299 BET bromodomain inhibitor

    CPI-0610; CPI0610; CPI 0610

     Potent and selective inhibitor for BRD4 BET bromodomain inhibitor Chemical Structure
  7. GC16726 BI-7273 BRD9 bromodomain inhibitor BI-7273 Chemical Structure
  8. GC16817 BI-9564 BRD9/7 specific inhibitor BI-9564 Chemical Structure
  9. GC16531 Bromodomain Inhibitor, (+)-JQ1 A selective inhibitor of BET bromodomains Bromodomain Inhibitor, (+)-JQ1 Chemical Structure
  10. GC10402 Bromosporine A non-specific bromodomain inhibitor Bromosporine Chemical Structure
  11. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs CAY17c Chemical Structure
  12. GC14699 CPI-203 BET bromodomain inhibitor CPI-203 Chemical Structure
  13. GC43320 CPI-268456 CPI-268456 (compound 141) is a potent BRD4 inhibitor with an IC50 of <0.5 μM. CPI-268456 Chemical Structure
  14. GC10382 CPI-637 CBP/EP300 bromodomain inhibitor CPI-637 Chemical Structure
  15. GC10524 GSK 525768A

    GSK525768A;GSK-525768A

     GSK 525768A Chemical Structure
  16. GC12440 GSK 5959 BRPF1 bromodomain inhibitor GSK 5959 Chemical Structure
  17. GC60182 GSK046

    GSK046

     GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 Chemical Structure
  18. GC14063 GSK1324726A

    GSK1324726A

     BET proteins inhibitor GSK1324726A Chemical Structure
  19. GC15789 GSK2801 inhibitor of BAZ2A and BAZ2B bromodomains GSK2801 Chemical Structure
  20. GC13025 GSK6853 BRPF1 inhibitor GSK6853 Chemical Structure
  21. GC16611 GW841819X

    BET bromodomain inhibitor

     GW841819X Chemical Structure
  22. GC50070 I-BET 151 dihydrochloride

    GSK1210151A dihydrochloride

     BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes I-BET 151 dihydrochloride Chemical Structure
  23. GC13187 I-BET 151 hydrochloride BET bromodomain inhibitor I-BET 151 hydrochloride Chemical Structure
  24. GC17073 I-BET-762

    GSK525762A

     I-BET-762 (I-BET762; GSK525762) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM. I-BET-762 Chemical Structure
  25. GC15747 I-BET151 (GSK1210151A)

    GSK1210151A

     I-BET151 (GSK1210151A) (GSK1210151A) is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively. I-BET151 (GSK1210151A) Chemical Structure
  26. GC12588 I-BRD9 BRD9 inhibitor I-BRD9 Chemical Structure
  27. GC43889 I-CBP112 (hydrochloride) cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators that modulate DNA replication, DNA repair, cell growth, transformation, and development. I-CBP112 (hydrochloride) Chemical Structure
  28. GC10727 Ischemin sodium salt CBP bromodomain inhibitor Ischemin sodium salt Chemical Structure
  29. GC45503 L-Moses (hydrochloride)

    L-45

       L-Moses (hydrochloride) Chemical Structure
  30. GC13148 MS436 BRD4 inhibitor MS436 Chemical Structure
  31. GC18750 NEO2734

    EP31670

     An orally active dual p300/CBP and BET bromodomain selective inhibitor NEO2734 Chemical Structure
  32. GC16763 NI-57 bromodomains of BRPF proteins inhibitor NI-57 Chemical Structure
  33. GC17482 OF-1 BRPF1B and BRPF2 bromodomain inhibitor OF-1 Chemical Structure
  34. GC17973 OTX-015

    HY15743, (-)-OTX015

     OTX-015 inhibits the binding of BRD2, BRD3, and BRD4 to acetylated histone 4 in a concentration-dependent manner, with IC50 values from 92-112nM. OTX-015 Chemical Structure
  35. GC14655 OXF BD 02 Selective inhibitor of the first bromodomain of BRD4 OXF BD 02 Chemical Structure
  36. GC15152 PF-CBP1 CBP/p300 bromodomain inhibitor PF-CBP1 Chemical Structure
  37. GC14361 PFI 3 inhibitor of polybromo 1 and SMARCA4 PFI 3 Chemical Structure
  38. GC10979 PFI 4 Potent and selective BRPF1 Bromodomain inhibitor PFI 4 Chemical Structure
  39. GC15375 PFI-1 (PF-6405761)

    PF06405761

     A BET bromodomain inhibitor PFI-1 (PF-6405761) Chemical Structure
  40. GC14199 RVX-208 RVX-208 (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC50s are 87 μM and 0.51 μM for BD1 and BD2, respectively. RVX-208 Chemical Structure
  41. GC45640 TP-238 (hydrochloride) A neuropeptide with diverse biological activities TP-238 (hydrochloride) Chemical Structure
  42. GC48408 TW9 A dual inhibitor of BRD4 and HDAC1 TW9 Chemical Structure
  43. GC14168 UMB-32 inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factor TAF1 and TAF1L UMB-32 Chemical Structure
  44. GC16794 UNC1215

    UNC 1215;UNC-1215

     Potent L3MBTL3 domain inhibitor UNC1215 Chemical Structure
  45. GC18096 UNC669 L3MBTL antagonist,potent and selective UNC669 Chemical Structure

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