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Home >> Signaling Pathways >> Chromatin/Epigenetics >> HDAC

HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. Product Name Information
  2. GC72591 (E,E)-RGFP966 (E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease. (E,E)-RGFP966 Chemical Structure
  3. GC73435 (S)-TNG260 (S)-TNG260 is an isomer of TNG260. (S)-TNG260 Chemical Structure
  4. GC39214 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation. 1-Naphthohydroxamic acid Chemical Structure
  5. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor 2-hexyl-4-Pentynoic Acid Chemical Structure
  6. GC17005 4-iodo-SAHA

    ISAHA

     class I and class II histone deacetylase (HDAC) inhibitor 4-iodo-SAHA Chemical Structure
  7. GC12667 4SC-202 4SC-202 (4SC-202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 4SC-202 Chemical Structure
  8. GC66055 5-Phenylpentan-2-one 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. 5-Phenylpentan-2-one Chemical Structure
  9. GC48986 9-hydroxy Stearic Acid

    9-HSA, 9-hydroxy Octadecanoic Acid

     A hydroxy fatty acid 9-hydroxy Stearic Acid Chemical Structure
  10. GA20481 Ac-Arg-Gly-Lys(Ac)-AMC Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin. Ac-Arg-Gly-Lys(Ac)-AMC Chemical Structure
  11. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin. Ac-Lys-AMC Chemical Structure
  12. GC34458 ACY-1083

    ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

     ACY-1083 Chemical Structure
  13. GC10417 ACY-241

    Citarinostat

     ACY-241 (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). ACY-241 has anticancer effects. ACY-241 Chemical Structure
  14. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM. ACY-738 Chemical Structure
  15. GC30782 ACY-775 An HDAC6 inhibitor ACY-775 Chemical Structure
  16. GC30526 ACY-957 ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 Chemical Structure
  17. GC65330 AES-135 AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM. AES-135 Chemical Structure
  18. GC48775 AES-350 An inhibitor of class I and class IIb HDACs AES-350 Chemical Structure
  19. GC40094 all-trans Retinoic Acid-d5

    atRA-d5, RA-d5, Vitamin A Acid-d5

     all-trans Retinoic acid-d5 is intended for use as an internal standard for the quantification of all-trans retinoic acid by GC- or LC-MS. all-trans Retinoic Acid-d5 Chemical Structure
  20. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol Chemical Structure
  21. GC67984 Alteminostat

    CKD-581

     Alteminostat Chemical Structure
  22. GC40674 APHA Compound 8

    MC 1353

     A class I and II HDAC inhibitor APHA Compound 8 Chemical Structure
  23. GC12961 Apicidin

    OSI 2040

    A cell-permeable HDAC inhibitor

     Apicidin Chemical Structure
  24. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  25. GC15962 Belinostat (PXD101) Belinostat (PXD101) is a novel hydroxamate-type inhibitor of histone deacetylase (HDAC) activity in HeLa cell extracts with an IC50 of 27 nM. Belinostat (PXD101) Chemical Structure
  26. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

    4PBA

     Benzenebutyric acid (4-Phenylbutyric acid) (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Benzenebutyric acid (4-Phenylbutyric acid) Chemical Structure
  27. GC12074 BG45 Novel HDAC3-selective inhibitor BG45 Chemical Structure
  28. GC25139 Biphenyl-4-sulfonyl chloride

    p-Phenylbenzenesulfonyl chloride, 4-Phenylbenzenesulfonyl chloride, p-Biphenylsulfonyl chloride

     Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. Biphenyl-4-sulfonyl chloride Chemical Structure
  29. GC12822 BML-210(CAY10433)

    NphenylN'(2Aminophenyl)hexamethylenediamide, CAY10433

     BML-210(CAY10433) is a novel HDAC inhibitor, and its mechanism of action has not been characterized. BML-210(CAY10433) Chemical Structure
  30. GC13926 BMS-345541(free base) BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK. BMS-345541(free base) Chemical Structure
  31. GC33331 BRD 4354 BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 Chemical Structure
  32. GC35551 BRD 4354 ditrifluoroacetate BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively. BRD 4354 ditrifluoroacetate Chemical Structure
  33. GC50322 BRD 9757 Potent and selective HDAC6 inhibitor BRD 9757 Chemical Structure
  34. GC38742 BRD-6929

    JQ12

     An HDAC1 and HDAC2 inhibitor BRD-6929 Chemical Structure
  35. GC72945 BRD2492 BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 Chemical Structure
  36. GC39551 BRD3308 BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 Chemical Structure
  37. GC40923 BRD4884 BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3, respectively. BRD4884 Chemical Structure
  38. GC13088 BRD6688 HDAC inhibitor BRD6688 Chemical Structure
  39. GC12484 BRD73954 potent and selective HDAC inhibitor BRD73954 Chemical Structure
  40. GC15410 Bufexamac COX inhibitor Bufexamac Chemical Structure
  41. GC64761 Butyric acid-13C1 Butyric acid-13C1 Chemical Structure
  42. GC43147 CAY10398

    MD 85, PX 089274

     CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. CAY10398 Chemical Structure
  43. GC12971 CAY10603

    HDAC 6 inhibitor, Histone Deacetylase Inhibitor VIII

    potent and selective inhibitor of HDAC6

     CAY10603 Chemical Structure
  44. GC43200 CAY10721 CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). CAY10721 Chemical Structure
  45. GC43201 CAY10722 CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). CAY10722 Chemical Structure
  46. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs CAY17c Chemical Structure
  47. GC14058 CBHA

    Histone Deacetylase Inhibitor II,m-Carboxycinnamic Acid bis-Hydroxamide

     CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis and suppresses tumor growth. CBHA Chemical Structure
  48. GC35668 CG-200745

    CG-200745

     CG-200745 (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG-200745 inhibits deacetylation of histone H3 and tubulin. CG-200745 induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. CG-200745 enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine and 5-Fluorouracil (5-FU; ). CG-200745 induces apoptosis and has anti-tumour effects. CG-200745 Chemical Structure
  49. GC39679 CG347B CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. CG347B Chemical Structure
  50. GC11975 CHAPS CHAPS Chemical Structure
  51. GC64942 CHDI-390576 CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. CHDI-390576 Chemical Structure
  52. GC16042 Chidamide

    CS 055, HBI 8000, Tucidinostat

     Chidamide (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. Chidamide Chemical Structure
  53. GC45717 Chlamydocin An HDAC inhibitor Chlamydocin Chemical Structure
  54. GC13408 CI994 (Tacedinaline)

    N-Acetyldinaline, Goe 5549, PD 123654, Tacedinaline

     An inhibitor of HDAC1, -2, and -3 CI994 (Tacedinaline) Chemical Structure
  55. GC73933 CM-1758 CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 Chemical Structure
  56. GC65426 CM-675 CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 Chemical Structure
  57. GC34165 Corin Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. Corin Chemical Structure
  58. GC43318 coumarin-SAHA

    coumarin-Suberoylanilide Hydroxamic Acid

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

     coumarin-SAHA Chemical Structure
  59. GC32565 CRA-026440 CRA-026440 is a potent, broad-spectrum HDAC inhibitor. CRA-026440 Chemical Structure
  60. GC67674 CRA-026440 hydrochloride CRA-026440 hydrochloride Chemical Structure
  61. GC70432 Crebinostat Crebinostat is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.7 nM, 1.0 nM, 2.0 nM and 9.3 nM for HDAC1, HDAC2, HDAC3 and HDAC6, respectively. Crebinostat Chemical Structure
  62. GC38412 Crotonoside

    2-Hydroxyadenosine, Isoguanine riboside, Isoguanosine, NSC 12161

     Crotonoside is a FLT3 and HDAC3/6 inhibitor that can be used to study acute myeloid leukemia (AML). Crotonoside Chemical Structure
  63. GC16008 CUDC-101 A multi-target inhibitor of HDACs, EGFR, and HER2 CUDC-101 Chemical Structure
  64. GC12115 CUDC-907

    CUDC-907

     CUDC is an orally bioavailable small molecule PI3K and HDAC dual inhibitor that acts on PI3K α And HDAC1 / 2 / 3 / 10 with IC50 of 19 nm and 1.7 nm / 5 nm / 1.8 nm / 2.8 nm. CUDC-907 Chemical Structure
  65. GC15830 Daminozide

    Alar, Aminozide, B 995, DIMG, DMASA, Kylar, SADH, Succinic Acid

     Selective inhibitor of KDM2/7 histone demethylases Daminozide Chemical Structure
  66. GC68988 DKFZ-748

    DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66) with anti-tumor activity.

     DKFZ-748 Chemical Structure
  67. GC35893 Domatinostat Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Domatinostat Chemical Structure
  68. GC13706 Droxinostat

    NS 41080

     An inhibitor of HDAC3, HDAC6, and HDAC8 Droxinostat Chemical Structure
  69. GC19129 EDO-S101

    Tinostamustine

     EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. EDO-S101 Chemical Structure
  70. GC64191 Elevenostat

    JB3-22

     Elevenostat (JB3-22) is a selective HDAC11 inhibitor (IC50=0.235??M). Anti-multiple myeloma (MM) activity. Elevenostat Chemical Structure
  71. GC11625 Entinostat (MS-275,SNDX-275)

    Entinostat, SNDX 275

     A histone deacetylase inhibitor Entinostat (MS-275,SNDX-275) Chemical Structure
  72. GC73828 F-SAHA

    p-Fluoro-SAHA

     F-SAHA is a HDAC inhibitor (HDACi) and its 18F labeled derivative can be used in tumor imaging research. F-SAHA Chemical Structure
  73. GC62461 FNDR-20123 FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 Chemical Structure
  74. GC65206 FT895 FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM. FT895 Chemical Structure
  75. GC33050 Givinostat (ITF-2357) Givinostat (ITF-2357) (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF-2357) Chemical Structure
  76. GC33159 Givinostat hydrochloride (ITF-2357 hydrochloride)

    ITF-2357 hydrochloride

     Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride (ITF-2357 hydrochloride) Chemical Structure
  77. GC18402 GSK3117391 GSK3117391 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1. GSK3117391 Chemical Structure
  78. GC70965 HD-TAC7 HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 Chemical Structure
  79. GC19190 HDAC-IN-4

    AZD 9468

     HDAC-IN-4 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-4 has no activity against HDAC class II. HDAC-IN-4 has antitumor activity. HDAC-IN-4 Chemical Structure
  80. GC66052 HDAC-IN-40 HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects. HDAC-IN-40 Chemical Structure
  81. GC33395 HDAC-IN-5 HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. HDAC-IN-5 Chemical Structure
  82. GC73392 HDAC-IN-52 HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 Chemical Structure
  83. GC73627 HDAC/JAK/BRD4-IN-1 HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor. HDAC/JAK/BRD4-IN-1 Chemical Structure
  84. GC69210 HDAC10-IN-1

    HDAC10-IN-1 (compound 13b) is an effective and highly selective inhibitor of HDAC10, with an IC50 of 58 nM. HDAC10-IN-1 can regulate autophagy in invasive FLT3-ITD positive acute myeloid leukemia cells.

     HDAC10-IN-1 Chemical Structure
  85. GC41495 HDAC3 Inhibitor

    Histone Deacetylase 3

     HDAC3 Inhibitor (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM. HDAC3 Inhibitor Chemical Structure
  86. GC68010 HDAC3-IN-T247 HDAC3-IN-T247 Chemical Structure
  87. GC49693 HDAC5 (human, recombinant) Active, pure human recombinant enzyme HDAC5 (human, recombinant) Chemical Structure
  88. GC73385 HDAC6 degrader-3 HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 Chemical Structure
  89. GC41085 HDAC6 Inhibitor

    Histone Deacetylase 6

     HDAC6 Inhibitor is a potent and selective HDAC6 inhibitor (IC50=36 nM). HDAC6 Inhibitor weakly inhibits other HDAC isoforms. HDAC6 Inhibitor inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM. HDAC6 Inhibitor Chemical Structure
  90. GC33317 HDAC6-IN-1 HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. HDAC6-IN-1 Chemical Structure
  91. GC73337 HDAC6-IN-13 HDAC6-IN-13 (Compound 35m) is a potent, highly selective, orally active HDAC6 inhibitor with an IC50 of 0.019 μM. HDAC6-IN-13 Chemical Structure
  92. GC73628 HDAC6-IN-23 HDAC6-IN-23 (compound 9) is an orally active HDAC6 inhibitor. HDAC6-IN-23 Chemical Structure
  93. GC73731 HDAC6-IN-26 HDAC6-IN-26 (compound 23) is a potent inhibitor of HDAC6. HDAC6-IN-26 Chemical Structure
  94. GC19189 HDAC8-IN-1

    MDK-7933

     HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM. HDAC8-IN-1 Chemical Structure
  95. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 Chemical Structure
  96. GC73263 HFY-4A HFY-4A is a HDAC inhibitor. HFY-4A Chemical Structure
  97. GC12334 HNHA

    Histone Deacetylase Inhibitor VI

     HDAC inhibitor HNHA Chemical Structure
  98. GC11574 HPOB HDAC6 inhibitor, potent and selective HPOB Chemical Structure
  99. GC73712 ITF 3756 ITF 3756 is a potent and selective HDAC6 inhibitor. ITF 3756 Chemical Structure
  100. GC17836 ITF2357 (Givinostat)

    HDAC inhibitor with anti-inflammatory and antineoplastic activities

     ITF2357 (Givinostat) Chemical Structure
  101. GC14597 ITSA-1 (ITSA1) ITSA-1 (ITSA1) is an activator of histone deacetylase (HDAC), and counteract trichostatin A (TSA)-induced cell cycle arrest, histone acetylation, and transcriptional activation. ITSA-1 (ITSA1) Chemical Structure

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