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HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

  1. Cat.No. Product Name Information
  2. GC11249 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  3. GC17005 4-iodo-SAHA class I and class II histone deacetylase (HDAC) inhibitor
  4. GC12667 4SC-202 Class I HDAC inhibitor
  5. GA20605 Ac-Lys-AMC Ac-Lys-AMC is cleaved by trypsin.
  6. GC34458 ACY-1083
  7. GC10417 ACY-241 Selective and orally active HDAC6 inhibitor
  8. GC19020 ACY-738 ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM; ACY-738 also inhibits HDAC1, HDAC2, and HDAC3, with IC50s of 94, 128, and 218 nM.
  9. GC30782 ACY-775
  10. GC30526 ACY-957
  11. GC12961 Apicidin

    Potent HDAC inhibitor

  12. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

  13. GC15962 Belinostat (PXD101)

    Hydroxamate-type HDAC inhibitor

  14. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)
  15. GC12074 BG45 Novel HDAC3-selective inhibitor
  16. GC12822 BML-210(CAY10433) Novel HDAC inhibitor
  17. GC13926 BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective
  18. GC33331 BRD 4354
  19. GC35551 BRD 4354 ditrifluoroacetate
  20. GC38742 BRD-6929
  21. GC13088 BRD6688 HDAC inhibitor

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