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HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

Products for  HDAC

  1. Cat.No. Product Name Information
  2. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Nampt-IN-3  Chemical Structure
  3. GC36691 Nanatinostat Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM. Nanatinostat  Chemical Structure
  4. GC15536 NCH 51 An HDAC inhibitor NCH 51  Chemical Structure
  5. GC13764 Nexturastat A HDAC6 inhibitor,highly potent and selective Nexturastat A  Chemical Structure
  6. GC32964 NKL 22 A selective HDAC1/3 inhibitor NKL 22  Chemical Structure
  7. GC48460 NR-160 An inhibitor of HDAC6 NR-160  Chemical Structure
  8. GC15040 NSC 3852 A tumor cell differentiating agent NSC 3852  Chemical Structure
  9. GC13925 Nullscript negative control of scriptaid, HDAC inhibitor Nullscript  Chemical Structure
  10. GC11360 ORY-1001 Selective inhibitor of KDM1A. ORY-1001  Chemical Structure
  11. GC17472 Oxamflatin HADC inhibitor Oxamflatin  Chemical Structure
  12. GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor Panobinostat (LBH589)  Chemical Structure
  13. GN10357 Parthenolide Parthenolide  Chemical Structure
  14. GC14682 PCI-24781 (CRA-024781) An HDAC inhibitor PCI-24781 (CRA-024781)  Chemical Structure
  15. GC18008 PCI-34051 A potent, selective HDAC8 inhibitor PCI-34051  Chemical Structure
  16. GC36905 PI3K/HDAC-IN-1 PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively. PI3K/HDAC-IN-1  Chemical Structure
  17. GC68474 Pivanex Pivanex  Chemical Structure
  18. GC33115 Pomiferin (NSC 5113) Pomiferin (NSC 5113) (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM). Pomiferin (NSC 5113)  Chemical Structure
  19. GC16734 Pracinostat (SB939)

    A pan-HDAC inhibitor

    Pracinostat (SB939)  Chemical Structure
  20. GC60310 Psammaplin A Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A  Chemical Structure
  21. GC11095 Pyroxamide A HDAC inhibitor Pyroxamide  Chemical Structure
  22. GC62411 QTX125 QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects. QTX125  Chemical Structure
  23. GC63730 QTX125 TFA QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 TFA exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects. QTX125 TFA  Chemical Structure
  24. GC33290 Remetinostat (SHP-141) Remetinostat (SHP-141) (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. Remetinostat (SHP-141)  Chemical Structure
  25. GC15879 Resminostat (RAS2410) Resminostat (RAS2410)  Chemical Structure
  26. GC14243 Resminostat hydrochloride An orally bioavailable HDAC inhibitor Resminostat hydrochloride  Chemical Structure
  27. GC10423 RG2833 An HDAC inhibitor RG2833  Chemical Structure
  28. GC14285 RGFP966

    RGFP966 is HDAC3 inhibitor with an IC50 of 0.08 μM. RGFP966 can suppress inflammatory responses.

    RGFP966  Chemical Structure
  29. GC14998 Rocilinostat (ACY-1215) A selective inhibitor of HDAC6 Rocilinostat (ACY-1215)  Chemical Structure
  30. GC11334 Romidepsin (FK228, depsipeptide) A class I HDAC inhibitor Romidepsin (FK228, depsipeptide)  Chemical Structure
  31. GC44865 SAHA-BPyne Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne  Chemical Structure
  32. GC44866 SAHA-d5 SAHA-d5 (SAHA-d5) is the deuterium labeled Vorinostat. SAHA-d5  Chemical Structure
  33. GC14439 Santacruzamate A (CAY10683) Santacruzamate A (CAY10683) (CAY-10683) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. Santacruzamate A (CAY10683)  Chemical Structure
  34. GC64684 SB-429201 SB-429201 is a potent and selective HDAC1 (IC50~1.5 μM). SB-429201 displays at least a 20-fold preference for HDAC1 inhibition over HDAC3 and HDAC8. SB-429201  Chemical Structure
  35. GC15315 Scriptaid HDAC inhibitor Scriptaid  Chemical Structure
  36. GC31511 Sinapinic acid (Sinapic acid) Sinapinic acid (Sinapic acid) (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Sinapinic acid (Sinapic acid)  Chemical Structure
  37. GC37643 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. SIS17  Chemical Structure
  38. GC69917 Snail/HDAC-IN-1

    Snail/HDAC-IN-1 is an effective dual-target inhibitor of Snail/HDAC. It has strong inhibitory activity against HDAC1 with an IC50 of 0.405 μM and a strong inhibitory effect on Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and reduces the expression of Snail protein, thereby inducing apoptosis in cells.

    Snail/HDAC-IN-1  Chemical Structure
  39. GC48084 Sodium 4-Phenylbutyrate-d11 Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Sodium 4-Phenylbutyrate-d11  Chemical Structure
  40. GC15857 Sodium butyrate

    Histone deacetylase inhibitor

    Sodium butyrate  Chemical Structure
  41. GC15002 Sodium Phenylbutyrate A chemical chaperone Sodium Phenylbutyrate  Chemical Structure
  42. GC38137 Splitomicin Inhibitor of yeast Sir2p Splitomicin  Chemical Structure
  43. GC19337 SR-4370 SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 uM, 0.58 uM, 0.006 uM, 2.3 uM, and 3.4 uM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370  Chemical Structure
  44. GC46226 SS-208 An HDAC6 inhibitor SS-208  Chemical Structure
  45. GC12976 Suberohydroxamic Acid Suberohydroxamic Acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively.Suberohydroxamic Acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.Suberohydroxamic Acid can be used for the study of medullary thyroid carcinoma (MTC). Suberohydroxamic Acid  Chemical Structure
  46. GC14016 Sulforaphane

    Sulforaphane (SFN) known as [1-isothiocyanato-4-(methylsulfinyl)butane].

    Sulforaphane  Chemical Structure
  47. GC64968 SW-100 SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100  Chemical Structure
  48. GC14340 Tasquinimod An orally-active anti-cancer compound Tasquinimod  Chemical Structure
  49. GC13591 TC-H 106 A tight-binding inhibitor of class I HDACs TC-H 106  Chemical Structure
  50. GC12019 TCS HDAC6 20b An HDAC6 inhibitor TCS HDAC6 20b  Chemical Structure
  51. GC37753 Tefinostat Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias. Tefinostat  Chemical Structure
  52. GC19406 TH34

    TH34 is a potent HDAC6/8/10 inhibitor

    TH34   Chemical Structure
  53. GC19360 TMP195 TMP195 is a potent and selective class IIa HDAC inhibitor with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively[1]. TMP195  Chemical Structure
  54. GC17703 TMP269 HDAC 4/5/7/9 inhibitor TMP269  Chemical Structure
  55. GC70040 TNG260

    TNG260 is a selective CoREST deacetylase (CoreDAC) inhibitor. TNG260 selectively inhibits HDAC1 10 times more than HDAC3. TNG260 leads to the inhibition of HDAC1 and reverses anti-PD1 resistance driven by STK11 deficiency. TNG260 reduces tumor infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.

    TNG260  Chemical Structure
  56. GC18915 Trapoxin A Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. Trapoxin A  Chemical Structure
  57. GC15526 Trichostatin A (TSA) A potent, reversible inhibitor of histone deacetylases Trichostatin A (TSA)  Chemical Structure
  58. GC61947 Triciferol Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities. Triciferol  Chemical Structure
  59. GC10839 Tubastatin A

    A potent HDAC6 inhibitor

    Tubastatin A  Chemical Structure
  60. GC45095 Tubastatin A (trifluoroacetate salt) Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A (trifluoroacetate salt)  Chemical Structure
  61. GC10322 Tubastatin A HCl Tubastatin A HCl (Tubastatin A HCl) is a potent and selectiveHDAC6inhibitor withIC50of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A HCl also inhibits HDAC10 and metallo-β-lactamase domain-containing protein2 (MBLAC2). Tubastatin A HCl  Chemical Structure
  62. GC37845 Tucidinostat An HDAC inhibitor Tucidinostat  Chemical Structure
  63. GC48408 TW9 A dual inhibitor of BRD4 and HDAC1 TW9  Chemical Structure
  64. GC14367 UF 010 Novel and selective class I HDAC inhibitor UF 010  Chemical Structure
  65. GC11424 Valproic acid HDAC1 inhibitor Valproic acid  Chemical Structure
  66. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor Valproic acid sodium salt (Sodium valproate)  Chemical Structure
  67. GC70109 Valproic acid-d15

    Valproic acid-d15 is the deuterated form of Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor with an IC50 value of 0.5-2 mM, inhibiting the activity of HDAC1 (IC50, 400 μM), while inducing the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid can be used for research on epilepsy, bipolar disorder, and migraines.

    Valproic acid-d15  Chemical Structure
  68. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6  Chemical Structure
  69. GC16143 Varenicline Hydrochloride α4β2 nicotinic receptor agonist Varenicline Hydrochloride  Chemical Structure
  70. GC17390 Vorinostat (SAHA, MK0683)

    An HDAC inhibitor

    Vorinostat (SAHA, MK0683)  Chemical Structure
  71. GC18206 WT161 WT161 is a potent inhibitor of HDAC6 with an IC50 value of 0.40 nM. WT161  Chemical Structure

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