HDAC
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
Products for HDAC
- Cat.No. Product Name Information
- GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death.
- GC36691 Nanatinostat Nanatinostat (CHR-3996) is a potent, class I selective and orally active histone deacetylase (HDAC) inhibitor with an IC50 of 8 nM.
- GC15536 NCH 51 An HDAC inhibitor
- GC13764 Nexturastat A HDAC6 inhibitor,highly potent and selective
- GC32964 NKL 22 A selective HDAC1/3 inhibitor
- GC48460 NR-160 An inhibitor of HDAC6
- GC15040 NSC 3852 A tumor cell differentiating agent
- GC13925 Nullscript negative control of scriptaid, HDAC inhibitor
- GC11360 ORY-1001 Selective inhibitor of KDM1A.
- GC17472 Oxamflatin HADC inhibitor
- GC12257 Panobinostat (LBH589) A pan-HDAC inhibitor
- GN10357 Parthenolide
- GC14682 PCI-24781 (CRA-024781) An HDAC inhibitor
- GC18008 PCI-34051 A potent, selective HDAC8 inhibitor
- GC36905 PI3K/HDAC-IN-1 PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively.
- GC68474 Pivanex
- GC33115 Pomiferin (NSC 5113) Pomiferin (NSC 5113) (NSC 5113) acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM).
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GC16734
Pracinostat (SB939)
A pan-HDAC inhibitor
- GC60310 Psammaplin A Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases.
- GC11095 Pyroxamide A HDAC inhibitor
- GC62411 QTX125 QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.
- GC63730 QTX125 TFA QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 TFA exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.
- GC33290 Remetinostat (SHP-141) Remetinostat (SHP-141) (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma.
- GC15879 Resminostat (RAS2410)
- GC14243 Resminostat hydrochloride An orally bioavailable HDAC inhibitor
- GC10423 RG2833 An HDAC inhibitor
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GC14285
RGFP966
RGFP966 is HDAC3 inhibitor with an IC50 of 0.08 μM. RGFP966 can suppress inflammatory responses.
- GC14998 Rocilinostat (ACY-1215) A selective inhibitor of HDAC6
- GC11334 Romidepsin (FK228, depsipeptide) A class I HDAC inhibitor
- GC44865 SAHA-BPyne Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.
- GC44866 SAHA-d5 SAHA-d5 (SAHA-d5) is the deuterium labeled Vorinostat.
- GC14439 Santacruzamate A (CAY10683) Santacruzamate A (CAY10683) (CAY-10683) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM.
- GC64684 SB-429201 SB-429201 is a potent and selective HDAC1 (IC50~1.5 μM). SB-429201 displays at least a 20-fold preference for HDAC1 inhibition over HDAC3 and HDAC8.
- GC15315 Scriptaid HDAC inhibitor
- GC31511 Sinapinic acid (Sinapic acid) Sinapinic acid (Sinapic acid) (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack.
- GC37643 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
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GC69917
Snail/HDAC-IN-1
Snail/HDAC-IN-1 is an effective dual-target inhibitor of Snail/HDAC. It has strong inhibitory activity against HDAC1 with an IC50 of 0.405 μM and a strong inhibitory effect on Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and reduces the expression of Snail protein, thereby inducing apoptosis in cells.
- GC48084 Sodium 4-Phenylbutyrate-d11 Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
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GC15857
Sodium butyrate
Histone deacetylase inhibitor
- GC15002 Sodium Phenylbutyrate A chemical chaperone
- GC38137 Splitomicin Inhibitor of yeast Sir2p
- GC19337 SR-4370 SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 uM, 0.58 uM, 0.006 uM, 2.3 uM, and 3.4 uM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.
- GC46226 SS-208 An HDAC6 inhibitor
- GC12976 Suberohydroxamic Acid Suberohydroxamic Acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively.Suberohydroxamic Acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.Suberohydroxamic Acid can be used for the study of medullary thyroid carcinoma (MTC).
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GC14016
Sulforaphane
Sulforaphane (SFN) known as [1-isothiocyanato-4-(methylsulfinyl)butane].
- GC64968 SW-100 SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes.
- GC14340 Tasquinimod An orally-active anti-cancer compound
- GC13591 TC-H 106 A tight-binding inhibitor of class I HDACs
- GC12019 TCS HDAC6 20b An HDAC6 inhibitor
- GC37753 Tefinostat Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias.
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GC19406
TH34
TH34 is a potent HDAC6/8/10 inhibitor
- GC19360 TMP195 TMP195 is a potent and selective class IIa HDAC inhibitor with IC50s of 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively[1].
- GC17703 TMP269 HDAC 4/5/7/9 inhibitor
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GC70040
TNG260
TNG260 is a selective CoREST deacetylase (CoreDAC) inhibitor. TNG260 selectively inhibits HDAC1 10 times more than HDAC3. TNG260 leads to the inhibition of HDAC1 and reverses anti-PD1 resistance driven by STK11 deficiency. TNG260 reduces tumor infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
- GC18915 Trapoxin A Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor.
- GC15526 Trichostatin A (TSA) A potent, reversible inhibitor of histone deacetylases
- GC61947 Triciferol Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.
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GC10839
Tubastatin A
A potent HDAC6 inhibitor
- GC45095 Tubastatin A (trifluoroacetate salt) Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.
- GC10322 Tubastatin A HCl Tubastatin A HCl (Tubastatin A HCl) is a potent and selectiveHDAC6inhibitor withIC50of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A HCl also inhibits HDAC10 and metallo-β-lactamase domain-containing protein2 (MBLAC2).
- GC37845 Tucidinostat An HDAC inhibitor
- GC48408 TW9 A dual inhibitor of BRD4 and HDAC1
- GC14367 UF 010 Novel and selective class I HDAC inhibitor
- GC11424 Valproic acid HDAC1 inhibitor
- GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
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GC70109
Valproic acid-d15
Valproic acid-d15 is the deuterated form of Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor with an IC50 value of 0.5-2 mM, inhibiting the activity of HDAC1 (IC50, 400 μM), while inducing the degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid can be used for research on epilepsy, bipolar disorder, and migraines.
- GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
- GC16143 Varenicline Hydrochloride α4β2 nicotinic receptor agonist
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GC17390
Vorinostat (SAHA, MK0683)
An HDAC inhibitor
- GC18206 WT161 WT161 is a potent inhibitor of HDAC6 with an IC50 value of 0.40 nM.