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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Histone Deacetylation

Histone Deacetylation

Products for  Histone Deacetylation

  1. Cat.No. Product Name Information
  2. GC46628 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline A building block and synthetic intermediate 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Structure
  3. GC46736 7-Bromoheptanoic Acid A building block 7-Bromoheptanoic Acid Chemical Structure
  4. GC48986 9-hydroxy Stearic Acid

    9-HSA, 9-hydroxy Octadecanoic Acid

     A hydroxy fatty acid 9-hydroxy Stearic Acid Chemical Structure
  5. GC48382 Ac-QPKK(Ac)-AMC

    Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, p53317-320 Substrate (Ac-QPKK(Ac)-AMC)

     A fluorogenic substrate for SIRT1, SIRT2, and SIRT3 Ac-QPKK(Ac)-AMC Chemical Structure
  6. GC48775 AES-350 An inhibitor of class I and class IIb HDACs AES-350 Chemical Structure
  7. GC49393 all-trans-13,14-Dihydroretinol A metabolite of all-trans retinoic acid all-trans-13,14-Dihydroretinol Chemical Structure
  8. GC40674 APHA Compound 8

    MC 1353

     A class I and II HDAC inhibitor APHA Compound 8 Chemical Structure
  9. GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid ATRA-BA Hybrid Chemical Structure
  10. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278 Chemical Structure
  11. GC11641 Boc-Lys(Ac)-AMC

    GPCR G2A/GPR132 agonist

     Boc-Lys(Ac)-AMC Chemical Structure
  12. GC48620 BPKDi A PKD inhibitor BPKDi Chemical Structure
  13. GC39551 BRD3308 BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 Chemical Structure
  14. GC40923 BRD4884 BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3, respectively. BRD4884 Chemical Structure
  15. GC46104 Butyric Acid-d7 An internal standard for the quantification of sodium butyrate Butyric Acid-d7 Chemical Structure
  16. GC43147 CAY10398

    MD 85, PX 089274

     CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. CAY10398 Chemical Structure
  17. GC41601 CAY10591

    SIRT1 Activator 3, Sirtuin 1 Activator 3

     CAY10591 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. CAY10591 Chemical Structure
  18. GC43201 CAY10722 CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). CAY10722 Chemical Structure
  19. GC49029 CAY17c An inhibitor of BRD4 and class I and class IIb HDACs CAY17c Chemical Structure
  20. GC43318 coumarin-SAHA

    coumarin-Suberoylanilide Hydroxamic Acid

    Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access.

     coumarin-SAHA Chemical Structure
  21. GC52368 DL-Sulforaphane Glutathione

    SFN-glutathione, SFN-GSH, Sulforaphane-GSH

     A metabolite of sulforaphane DL-Sulforaphane Glutathione Chemical Structure
  22. GC43806 HC Toxin

    Toxin I (Helminthosporium carbonum)

     HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). HC Toxin Chemical Structure
  23. GC41495 HDAC3 Inhibitor

    Histone Deacetylase 3

     HDAC3 Inhibitor (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM. HDAC3 Inhibitor Chemical Structure
  24. GC49693 HDAC5 (human, recombinant) Active, pure human recombinant enzyme HDAC5 (human, recombinant) Chemical Structure
  25. GC91389 J27644 J27644 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 10 nM). J27644 Chemical Structure
  26. GC47579 L-Pyrohomoglutamic Acid

    L-Pyro-α-aminoadipic Acid, 6-Oxo-L-pipecolic Acid

     An amino acid building block L-Pyrohomoglutamic Acid Chemical Structure
  27. GC52188 MDL 800 MDL 800 Chemical Structure
  28. GC48805 Methapyrilene (hydrochloride) An H1 receptor antagonist and non-genotoxic carcinogen Methapyrilene (hydrochloride) Chemical Structure
  29. GC49270 Nicotinamide-d4

    Niacinamide-d4, Nicotinic Acid Amide-d4, Vitamin B3 Amide-d4

     An internal standard for the quantification of nicotinamide Nicotinamide-d4 Chemical Structure
  30. GC52166 NN-390 NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB). NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma). NN-390 Chemical Structure
  31. GC48460 NR-160 An inhibitor of HDAC6 NR-160 Chemical Structure
  32. GC49815 Oleuropein aglycone

    3,4-DHPEA-EA

     A polyphenol with diverse biological activities Oleuropein aglycone Chemical Structure
  33. GC48600 Panobinostat-d4 (hydrochloride)

    LBH-589-d4

     Panobinostat-d4 (hydrochloride) Chemical Structure
  34. GC19936 Quisinostat dihydrochloride

    JNJ-26481585 dihydrochloride

     Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity. Quisinostat dihydrochloride Chemical Structure
  35. GC44865 SAHA-BPyne

    Click Tag SAHA-BPyne, Suberoylanilide Hydroxamic AcidBPyne

     Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne Chemical Structure
  36. GC44866 SAHA-d5

    Suberoylanilide Hydroxamic Acid-d5, Vorinostat-d5

     SAHA-d5 (SAHA-d5) is the deuterium labeled Vorinostat. SAHA-d5 Chemical Structure
  37. GC48084 Sodium 4-Phenylbutyrate-d11

    Benzenebutanoic acid-d11, TriButyrate-d11

     Phenylbutyrate-d11 (sodium) is deuterium labeled Sodium 4-phenylbutyrate. Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. Sodium 4-Phenylbutyrate-d11 Chemical Structure
  38. GC46226 SS-208 An HDAC6 inhibitor SS-208 Chemical Structure
  39. GC18915 Trapoxin A Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. Trapoxin A Chemical Structure
  40. GC45080 Trichostatin C

    Antibiotic 145-A

     Trichostatin C is a glycosylated derivative of trichostatin A, the antifungal antibiotic that reversibly inhibits histone deacetylase. Trichostatin C Chemical Structure
  41. GC45095 Tubastatin A (trifluoroacetate salt) Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Tubastatin A (trifluoroacetate salt) Chemical Structure
  42. GC48408 TW9 A dual inhibitor of BRD4 and HDAC1 TW9 Chemical Structure
  43. GC45137 Valproic Acid Acyl-D-Glucuronide

    Valproic Acid Gluclonide

     Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid. Valproic Acid Acyl-D-Glucuronide Chemical Structure
  44. GC19384 WT-161 WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM. WT-161 Chemical Structure

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