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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Histone Demethylases

Histone Demethylases

Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone.  So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.

Products for  Histone Demethylases

  1. Cat.No. Product Name Information
  2. GC72837 α-Hydroxyglutaric acid-d4 disodium

    2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium

     α-droxyglutaric acid-d4 (disodium) is the deuterium labeled α-droxyglutaric acid disodium. α-Hydroxyglutaric acid-d4 disodium Chemical Structure
  3. GC60004 (rel)-Tranylcypromine D5 hydrochloride Tranylcypromine-d5 (SKF 385-d5) hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine D5 hydrochloride Chemical Structure
  4. GC11873 2,4-Pyridinedicarboxylic Acid 2,4-Pyridinedicarboxylic Acid (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-Pyridinedicarboxylic Acid is a target chemical in the field of bio-based plastics. 2,4-Pyridinedicarboxylic Acid Chemical Structure
  5. GC42075 2,4-Pyridinedicarboxylic Acid (hydrate)

    2,4-Dicarboxylpyridine, 2,4-PDCA

     2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. 2,4-Pyridinedicarboxylic Acid (hydrate) Chemical Structure
  6. GC12961 Apicidin

    OSI 2040

    A cell-permeable HDAC inhibitor

     Apicidin Chemical Structure
  7. GC17820 AS8351

    NCI 51355, NSC 51355

     histone demethylase inhibitor AS8351 Chemical Structure
  8. GC18159 BAY-598

    A potent and selective SMYD2 inhibitor

     BAY-598 Chemical Structure
  9. GC16114 Bizine LSD1 inhibitor Bizine Chemical Structure
  10. GC64865 Bomedemstat

    IMG-7289

     Bomedemstat (IMG-7289) is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis. Bomedemstat Chemical Structure
  11. GC68795 Bomedemstat dihydrochloride

    IMG-7289 dihydrochloride

    Bomedemstat (IMG-7289) dihydrochloride is an orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1). Bomedemstat dihydrochloride can increase the methylation of H3K4 and H3K9, which then alters gene expression. Bomedemstat dihydrochloride has anti-cancer activity, inhibiting cancer cell proliferation and inducing apoptosis.

     Bomedemstat dihydrochloride Chemical Structure
  12. GC67921 Bomedemstat ditosylate

    IMG-7289 ditosylate

     Bomedemstat ditosylate Chemical Structure
  13. GC65879 Bomedemstat hydrochloride

    IMG-7289 hydrochloride

     Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis. Bomedemstat hydrochloride Chemical Structure
  14. GC35621 CBB1003 CBB1003 is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. CBB1003 Chemical Structure
  15. GC35622 CBB1003 hydrochloride CBB1003 Hcl is a novel histone demethylase LSD1 inhibitor with IC50 of 10.54 uM. CBB1003 hydrochloride Chemical Structure
  16. GC14151 CBB1007 LSD1 inhibitor,potent and selective CBB1007 Chemical Structure
  17. GC35623 CBB1007 hydrochloride CBB1007 Hcl is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). CBB1007 hydrochloride Chemical Structure
  18. GC35624 CBB1007 trihydrochloride CBB1007 trihydrochloride is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 μM for hLSD1). CBB1007 trihydrochloride Chemical Structure
  19. GC34165 Corin Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. Corin Chemical Structure
  20. GC25304 CP2 CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively. CP2 Chemical Structure
  21. GC10774 CPI-455

    KDM5 inhibitor

     CPI-455 Chemical Structure
  22. GC25305 CPI-455 HCl CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.This product has poor solubility, animal experiments are available, cell experiments please choose carefully! CPI-455 HCl Chemical Structure
  23. GC15830 Daminozide

    Alar, Aminozide, B 995, DIMG, DMASA, Kylar, SADH, Succinic Acid

     Selective inhibitor of KDM2/7 histone demethylases Daminozide Chemical Structure
  24. GC33013 DDP-38003 dihydrochloride DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. DDP-38003 dihydrochloride Chemical Structure
  25. GC34296 DDP-38003 trihydrochloride DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. DDP-38003 trihydrochloride Chemical Structure
  26. GC60833 FB23 FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity. FB23 Chemical Structure
  27. GC34314 GSK 690 Hydrochloride GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM. GSK 690 Hydrochloride Chemical Structure
  28. GC10617 GSK J1 A dual inhibitor of JMJD3 and UTX GSK J1 Chemical Structure
  29. GC13086 GSK J2 inactive control of GSK J1, JMJD3 (KDM6B) and UTX (KDM6A) inhibitor GSK J2 Chemical Structure
  30. GC12997 GSK J4 free base GSK J4 free base is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK J4 free base inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK J4 free base induces endoplasmic reticulum stress-related apoptosis. GSK J4 free base Chemical Structure
  31. GC15497 GSK J4 HCl GSK-J4 HCl is a small-molecule inhibitor with highly efficient cell permeability and a pharmacologically selective inhibitor that preserves H3K27 methylation by inhibiting KDM6B. GSK J4 HCl Chemical Structure
  32. GC17118 GSK J5

    inactive isomer of GSK J4, KDM inhibitor

     GSK J5 Chemical Structure
  33. GC39491 GSK-3484862 GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity. GSK-3484862 Chemical Structure
  34. GC36195 GSK-J1 lithium salt GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 of 60 nM towards KDM6B. GSK-J1 lithium salt Chemical Structure
  35. GC12288 GSK-J1 sodium salt A neuropeptide with diverse biological activities GSK-J1 sodium salt Chemical Structure
  36. GC43792 GSK-J2 (sodium salt) The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J2 (sodium salt) Chemical Structure
  37. GC43794 GSK-J5 (hydrochloride) The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J5 (hydrochloride) Chemical Structure
  38. GC15368 GSK-LSD1 2HCl irreversible, and selective LSD1 inhibitor GSK-LSD1 2HCl Chemical Structure
  39. GC32764 GSK-LSD1 Dihydrochloride An LSD1 inhibitor GSK-LSD1 Dihydrochloride Chemical Structure
  40. GC11578 GSK2879552 Novel and irreversible LSD1 inhibitor GSK2879552 Chemical Structure
  41. GC62719 GSK2879552 dihydrochloride GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity. GSK2879552 dihydrochloride Chemical Structure
  42. GC34604 GSK467 GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members. GSK467 Chemical Structure
  43. GC72852 Helenalin acetate Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate Chemical Structure
  44. GC69273 INCB059872 dihydrochloride

    INCB059872 dihydrochloride is an effective, orally active, selective and irreversible inhibitor of lysine-specific demethylase 1 (LSD1). It can be used for research on myeloid leukemia.

     INCB059872 dihydrochloride Chemical Structure
  45. GC17754 IOX 1 histone demethylase JMJD inhibitor IOX 1 Chemical Structure
  46. GC73462 JHDM-IN-1 JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively. JHDM-IN-1 Chemical Structure
  47. GC15603 JIB-04

    JHDM Inhibitor VII, NSC 693627

     Jumonji histone demethylase inihibitor JIB-04 Chemical Structure
  48. GC64841 JQKD82 trihydrochloride

    JADA82 trihydrochloride; PCK82 trihydrochloride

     JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma. JQKD82 trihydrochloride Chemical Structure
  49. GC36388 KDM2A/7A-IN-1 KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16?μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. KDM2A/7A-IN-1 Chemical Structure
  50. GC70823 KDM2B-IN-1 KDM2B-IN-1 is a histone demethylase (kdm2b) inhibitor and can be used for hyperproliferative diseases research. KDM2B-IN-1 Chemical Structure
  51. GC69327 KDM2B-IN-4

    KDM2B-IN-4 is a histone demethylase KDM2B inhibitor. It can be used for cancer research. For more information, please refer to compound 182b in patent document WO2016112284A1.

     KDM2B-IN-4 Chemical Structure
  52. GC36389 KDM4-IN-2 KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7?nM for KDM4A and KDM5B, respectively. KDM4-IN-2 Chemical Structure
  53. GC69328 KDM4C-IN-1

    KDM4C-IN-1 (Compound 4d) is an effective inhibitor of KDM4C with an IC50 of 8 nM. It inhibits the growth of HepG2 and A549 cells with IC50 values of 0.8 μM and 1.1 μM, respectively.

     KDM4C-IN-1 Chemical Structure
  54. GC31887 KDM4D-IN-1 KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. KDM4D-IN-1 Chemical Structure
  55. GC69329 KDM5-C49 hydrochloride

    KDOAM-20 hydrochloride

    KDM5-C49 (KDOAM-20) hydrochloride is an effective and selective inhibitor of KDM5 demethylases, with IC50 values of 40 nM, 160 nM, and 100 nM for KDM5A, KDM5B, and KDM5C respectively. It can be used in cancer research.

     KDM5-C49 hydrochloride Chemical Structure
  56. GC39394 KDM5-C70

    KDOAM-21

     KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels. KDM5-C70 Chemical Structure
  57. GC32790 KDM5-IN-1 KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. KDM5-IN-1 Chemical Structure
  58. GC32842 KDM5A-IN-1 KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B). KDM5A-IN-1 Chemical Structure
  59. GC38709 KDOAM-25 citrate KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 citrate Chemical Structure
  60. GC73220 LSD1-IN-24 LSD1-IN-24(compound 3S) is a selective LSD1 inhibitor with IC50 = 0.247 μM. LSD1-IN-24 Chemical Structure
  61. GC73549 LSD1-IN-27 LSD1-IN-27 (Compound 5ac) is a LSD1 inhibitor (IC50: 13 nM). LSD1-IN-27 Chemical Structure
  62. GC73859 LSD1-IN-30 LSD1-IN-30 (compound 3) is a potent inhibitor of lysine-specific demetlase 1 (LSD1), with the IC50 value of 0.291 μM. LSD1-IN-30 Chemical Structure
  63. GC36484 LSD1-IN-5 LSD1-IN-5 (Compound 4e) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM. LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 Chemical Structure
  64. GC36485 LSD1-IN-6 LSD1-IN-6 (Compound 4m) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM. LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 Chemical Structure
  65. GC62434 LSD1/HDAC6-IN-1 LSD1/HDAC6-IN-1 is an orally active dual inhibitor of lysine specific demethylase 1(LSD1)/Histone deacetylase 6 (HDAC6), with anti-tumor activity. LSD1/HDAC6-IN-1 can be used for the research of multiple myeloma (MM). LSD1/HDAC6-IN-1 Chemical Structure
  66. GC13534 Lysine-specific Demethylase Inhibitor (1C)

    KDM1 Inhibitor I|LSD1 Inhibitor

     lysine-specific demethylase Inhibitor Lysine-specific Demethylase Inhibitor (1C) Chemical Structure
  67. GC47586 Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) An LSD1 inhibitor Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) Chemical Structure
  68. GC65254 MC4355 MC4355 is a dual inhibitor of EZH2 and histone deacetylase (HDAC). MC4355 Chemical Structure
  69. GC44184 Methylstat (hydrate) Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. Methylstat (hydrate) Chemical Structure
  70. GC12557 ML324

    CID-44143209

     JMJD2 demethylase inhibitor, potent and cell-permeable ML324 Chemical Structure
  71. GC12458 N-Oxalylglycine

    NOG

    cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E.

     N-Oxalylglycine Chemical Structure
  72. GC65138 NCDM-32B NCDM-32B is a potent and selective KDM4 inhibitor that impaires viability and transforming phenotypes of breast cancer. NCDM-32B Chemical Structure
  73. GC19410 NCGC00244536

    NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM

     NCGC00244536 Chemical Structure
  74. GC32896 NCGC00247743 NCGC00247743 is a histone lysine demethylase KDM4 inhibitor. NCGC00247743 Chemical Structure
  75. GC50136 NSC 636819 KDM4A/KDM4B inhibitor NSC 636819 Chemical Structure
  76. GC17314 OG-L002 LSD1 inhibitor,potent and specific OG-L002 Chemical Structure
  77. GC11792 OG-L002 HCl LSD1 inhibitor,potent and specific OG-L002 HCl Chemical Structure
  78. GC36818 ORY-1001(trans)

    ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride

     Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. ORY-1001(trans) Chemical Structure
  79. GC73981 P3FI-63 P3FI-63 is a KDM3B inhibitor with a IC50 value of 7 μM. P3FI-63 Chemical Structure
  80. GC15301 PBIT

    2-​p-​tolyl-1,​2-​Benzisothiazolin-​3-​one

     JARID1 family demethylases inhibitor PBIT Chemical Structure
  81. GC62678 PFI-90 PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). PFI-90 Chemical Structure
  82. GC44668 Posaconazole D-Glucuronide

    Posaconazole N-β-D-Glucuronide

     Posaconazole D-glucuronide is a metabolite of the antifungal agent posaconazole. Posaconazole D-Glucuronide Chemical Structure
  83. GC90195 Posaconazole-d5

    An internal standard for the quantification of posaconazole

     Posaconazole-d5 Chemical Structure
  84. GC14066 Procaine Sodium channel inhibitor Procaine Chemical Structure
  85. GC44685 Procaine (hydrochloride)

    Novocaine

     Procaine (hydrochloride) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant. Procaine (hydrochloride) Chemical Structure
  86. GC49116 Prohexadione

    BX-112

     A plant growth regulator Prohexadione Chemical Structure
  87. GC32699 QC6352 QC6352 is an orally available, selective and potent KDM4C inhibitor with an IC50 of 35 nM. QC6352 Chemical Structure
  88. GC10148 RN 1 dihydrochloride

    LSD1 Inhibitor IV

     LSD1 inhibitor, potent and selective RN 1 dihydrochloride Chemical Structure
  89. GC33339 S 2101 S 2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s. S 2101 Chemical Structure
  90. GC64303 S2116 S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice. S2116 Chemical Structure
  91. GC64902 S2157 S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells. S2157 Chemical Structure
  92. GC32820 Seclidemstat (SP-2577)

    SP-2577

     Seclidemstat (SP-2577) is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat (SP-2577) promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat (SP-2577) can be used for the research of Ewing Sarcoma. Seclidemstat (SP-2577) Chemical Structure
  93. GC63456 Seclidemstat mesylate

    SP-2577 mesylate

     Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma. Seclidemstat mesylate Chemical Structure
  94. GC14631 SP2509

    HCI-2509, LSD1 Inhibitor VII

     Demethylase 1 (LSD1) antagonist, novel Lysine-specific SP2509 Chemical Structure
  95. GC33038 T-3775440 hydrochloride T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM. T-3775440 hydrochloride Chemical Structure
  96. GC65456 T-448 T-448 is a specific, orally active and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 Chemical Structure
  97. GC63437 TAK-418 TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 Chemical Structure
  98. GC10319 TC-E 5002 TC-E 5002 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). TC-E 5002 inhibits growth of HeLa and KYSE-150 cancer cells in vitro. TC-E 5002 Chemical Structure
  99. GC45029 TFMB-R-2-HG TFMB-R-2-HG is a cell-permeable form of (R)-2-hydroxyglutarate ((R)-2-HG). TFMB-R-2-HG Chemical Structure
  100. GC70033 TK-129

    TK-129 is an orally effective, low-toxicity and potent KDM5B inhibitor (with high affinity; IC50=44 nM).

     TK-129 Chemical Structure
  101. GC11576 Tranylcypromine (2-PCPA) HCl (1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride is a potent antidepressant agent. Tranylcypromine (2-PCPA) HCl Chemical Structure

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