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Histone Methyltransferase

Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).

  1. Cat.No. Product Name Information
  2. GC11340 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
  3. GC13634 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
  4. GC17907 3-Deazaneplanocin A (DZNep) hydrochloride SAHH and ENZ2 inhibitor
  5. GC13145 3-Deazaneplanocin,DZNep S-adenosylhomocysteine and EZH2 inhibitor
  6. GC16015 A 366 G9a/GLP histone lysine methyltransferase inhibitor
  7. GC32861 A-196
  8. GC33187 A-395 (A395)
  9. GC30503 A-893
  10. GC16509 Adox

    indirect methyltransferase inhibitor

  11. GC17275 AMI-1 PRMT1 inhibitor
  12. GC17546 AMI5 protein methyltransferase inhibitor
  13. GC10905 Amodiaquine dihydrochloride dihydrate histamine N-methyl transferase inhibitor
  14. GC13744 AZ505 SMYD2 inhibitor,potent and selective
  15. GC13103 AZ505 ditrifluoroacetate SMYD2 inhibitor
  16. GC18159 BAY-598

    Potent and selective SMYD2 inhibitor

  17. GC18161 BCI-121

    A substrate-competitive SMYD3 inhibitor 

  18. GC12171 BIX 01294

    G9a and GLP inhibitor

  19. GC33301 BIX-01338 hydrate (BIX01338 hydrate)
  20. GC10259 BRD4770 novel G9a(EHMT2) inhibitor
  21. GC32988 BRD9539

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