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Home >> Signaling Pathways >> Chromatin/Epigenetics >> MicroRNA

MicroRNA

MiRNAs are 21-25 nucleotide RNAs that negatively regulate gene expression through translational repression or cleavage of a target mRNA. They are transcribed as precursors that are processed by the nucleases Drosha and Dicer.

Small molecules targeting the secondary structure of precursor miRNAs can be more selective modulators of function than oligonucleotides that target RNA sequence.

MicroRNAs (miRNAs) and promoter hypermethylation are vital epigenetic mechanisms for transcriptional inactivation of tumor suppressor.

Targets for  MicroRNA

Products for  MicroRNA

  1. Cat.No. Product Name Information
  2. GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid Chemical Structure
  3. GC73027 Cobomarsen sodium

    MRG-106 sodium

     Cobomarsen sodium is an oligonucleotide inhibitor of miR-155. Cobomarsen sodium Chemical Structure
  4. GC64115 Gypenoside LI Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration. Gypenoside LI Chemical Structure
  5. GC65289 Lademirsen

    SAR339375; RG-012

    Lademirsen (SAR339375; RG-012) is a single stranded, chemically modified oligonucleotide that binds to and inhibits the function of miR-21.

     Lademirsen Chemical Structure
  6. GC14362 Lin28 1632 Lin28 1632 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28 1632 Chemical Structure
  7. GC36464 LIN28 inhibitor LI71 LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28’s activity against let-7 in leukemia cells and embryonic stem cells. LIN28 inhibitor LI71 Chemical Structure
  8. GC30501 Lin28-let-7a antagonist 1 Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction. Lin28-let-7a antagonist 1 Chemical Structure
  9. GC72476 MicroRNA Agomir Negative Control MicroRNA Agomir Negative Control is a chemically-modified double-strand miRNA mimic, and can be used as a negative control. MicroRNA Agomir Negative Control Chemical Structure
  10. GC72479 MicroRNA Antagomir Negative Control MicroRNA Antagomir Negative Control is a chemically-modified oligonucleotide (2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification), and can be used as a negative control. MicroRNA Antagomir Negative Control Chemical Structure
  11. GC72478 MicroRNA Inhibitor Negative Control MicroRNA Inhibitor Negative Control is a full-length nucleotide 2'-methoxy modified oligonucleotide, and can be used as a negative control. MicroRNA Inhibitor Negative Control Chemical Structure
  12. GC73454 microRNA-21-IN-3 microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels. microRNA-21-IN-3 Chemical Structure
  13. GC32929 MIR96-IN-1 MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively. MIR96-IN-1 Chemical Structure
  14. GC64487 Miravirsen

    SPC-3649

     Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122. Miravirsen Chemical Structure
  15. GC72477 mmu-miR-1191a antagomir mmu-miR-1191a antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. mmu-miR-1191a antagomir Chemical Structure
  16. GC70682 MTL-CEBPA sodium MTL-CEBPA (sodium) is the sodium form of MTL-CEBPA . MTL-CEBPA sodium Chemical Structure
  17. GC38839 Pseudoprotodioscin Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Pseudoprotodioscin Chemical Structure
  18. GC70677 Remlarsen Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen Chemical Structure
  19. GC70678 Remlarsen sodium Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen sodium Chemical Structure
  20. GC73074 RGLS4326 sodium

    RG4326 sodium

     RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 sodium Chemical Structure
  21. GC64499 RJW100 RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively. RJW100 Chemical Structure
  22. GC32973 SID 3712249 (MiR-544 Inhibitor 1)

    MiR-544 Inhibitor 1

     SID 3712249 (MiR-544 Inhibitor 1) (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 (MiR-544 Inhibitor 1) binds directly to the precursor miRNA. SID 3712249 (MiR-544 Inhibitor 1) blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 (MiR-544 Inhibitor 1) can be used in the research of cancers, such as breast cancer. SID 3712249 (MiR-544 Inhibitor 1) Chemical Structure
  23. GC74257 Skullcapflavone I

    Panicolin

     Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I Chemical Structure
  24. GC32435 Targapremir-210

    TGP-210

     Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM). Targapremir-210 Chemical Structure
  25. GC70022 TGP-377/421

    Targapre-miR-377/421

    TGP-377/421 (Targapre-miR-377/421) is an effective inhibitor of miR-377 and miR-421, which binds to their functional sites.

     TGP-377/421 Chemical Structure

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