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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Protein Arginine Deiminase

Protein Arginine Deiminase

Protein arginine deiminases (PADs) is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. In humans, the PAD family is composed of five, calcium dependent isozymes (PADs 1-4 and 6), which share roughly 50% sequence similarity. PADs are found in a myriad of cell and tissue types, including the epidermis and uterus (PAD1), skeletal muscle, brain, inflammatory cells, several cancer cell lines, and secretory glands (PAD2), hair follicles and keratinocytes (PAD3), granulocytes and several types of cancer (PAD4), and oocytes and embryos (PAD6). PAD4, the best characterized isozyme, has also been shown to citrullinate a number of other proteins, including p300, ING4, RPS2, lamin C, and nucleophosmin.

Targets for  Protein Arginine Deiminase

Products for  Protein Arginine Deiminase

  1. Cat.No. Product Name Information
  2. GC66379 AFM-30a hydrochloride AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis. AFM-30a hydrochloride Chemical Structure
  3. GC35480 BB-Cl-Amidine hydrochloride BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor. BB-Cl-Amidine hydrochloride Chemical Structure
  4. GC35706 Cl-amidine

    Cl-amidine (N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine amide), is a PAD4 inactivator with enhanced potency.

     Cl-amidine Chemical Structure
  5. GC18925 Cl-Amidine (hydrochloride) Cl-amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 uM for PAD1, PAD3, and PAD4 in vitro, respectively). Cl-Amidine (hydrochloride) Chemical Structure
  6. GC63780 D-Cl-amidine hydrochloride D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity. D-Cl-amidine hydrochloride Chemical Structure
  7. GC19184 GSK484 hydrochloride GSK484 is a selective PAD4 inhibitor, has been used as an anti-ischemic compound and exerts inhibitory activity against PAD4. GSK484 hydrochloride Chemical Structure
  8. GC73447 JBI-589 JBI-589 is a non-covalent PAD4 isoform-selective inhibitor with oral bioavailability. JBI-589 Chemical Structure
  9. GC67873 PAD-IN-2 PAD-IN-2 Chemical Structure
  10. GC64367 PAD2-IN-1 PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 Chemical Structure
  11. GC66335 PAD2-IN-1 hydrochloride PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold). PAD2-IN-1 hydrochloride Chemical Structure
  12. GC73542 PAD4-IN-2 TFA PAD4-IN-2 (compound 5i) TFA is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 TFA Chemical Structure
  13. GC32303 Streptonigrin (Bruneomycin)

    NSC 45383, NSC 56748, NSC 83950

     Streptonigrin (Bruneomycin) (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin (Bruneomycin) Chemical Structure
  14. GC33261 YW3-56 YW3-56 Chemical Structure

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