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Home >> Signaling Pathways >> Chromatin/Epigenetics >> Sirtuin

Sirtuin

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

Products for  Sirtuin

  1. Cat.No. Product Name Information
  2. GC73817 2-APQC 2-APQC is a SIRT3 activator with the Kd value of 2.756 μM. 2-APQC Chemical Structure
  3. GC19013 3-TYP 3-TYP inhibit SIRT3 with an IC50 of 16 nM, and is more potent over SIRT1 and SIRT2 with IC50 of 88 nM and 92 nM, respectively. 3-TYP Chemical Structure
  4. GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor 4'-bromo-Resveratrol Chemical Structure
  5. GC71995 5-Heptadecylresorcinol 5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol Chemical Structure
  6. GC62651 7-Chloro-4-(piperazin-1-yl)quinoline 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinoline Chemical Structure
  7. GC64527 ADTL-SA1215 ADTL-SA1215 is a first-in-class specific small-molecule activator of SIRT3 that modulates autophagy in triple negative breast cancer. ADTL-SA1215 Chemical Structure
  8. GC17881 AGK 2 AGK2 is a selective SIRT2 inhibitor, with an IC50 of 3.5 µM. AGK2 inhibits SIRT1 and SIRT3 with IC50 of 30 and 91 µM, respectively. AGK 2 Chemical Structure
  9. GC15931 AGK7

    SIRT2 Inhibitor (Inactive Control)

     cell-permeable, selective inhibitor of SIRT2 AGK7 Chemical Structure
  10. GN10413 Agrimol B Agrimol B Chemical Structure
  11. GC10676 AK-7

    selective and brain-permeable SIRT2 inhibitor

     AK-7 Chemical Structure
  12. GC62886 Cannabisin F Cannabisin F Chemical Structure
  13. GC18228 CAY10602 Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD-dependent protein deacetylase that has been implicated in cell metabolism, differentiation, stress and DNA damage response, and the control of multidrug resistance in cancer. CAY10602 Chemical Structure
  14. GC64255 CHIC35 CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 ?M). CHIC35 Chemical Structure
  15. GC68900 CrBKA

    CrBKA is a weakly active fluorescent small molecule substrate of SIRT6.

     CrBKA Chemical Structure
  16. GC34187 Dihydrocoumarin (Hydrocoumarin)

    DHC

     Dihydrocoumarin (Hydrocoumarin) is a compound found in Melilotus officinalis. Dihydrocoumarin (Hydrocoumarin) is a yeast Sir2p inhibitor. Dihydrocoumarin (Hydrocoumarin) also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively. Dihydrocoumarin (Hydrocoumarin) Chemical Structure
  17. GC69033 E1231

    1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one

    E1231 is an orally effective activator of Sirtuin 1 (SIRT1) with an EC50 of 0.83 μM, which can regulate cholesterol and lipid metabolism. E1231 interacts with both SIRT1 and liver X receptor-α (LXRα) and increases the expression of ATP-binding cassette transporter A1 (ABCA1). E1231 also reduces the formation of atherosclerotic plaques in ApoE-/- mouse models. E1231 can be used for research on diseases related to cholesterol and lipid disorders.

     E1231 Chemical Structure
  18. GC64575 Et-29 Et-29 is a potent and selective SIRT5 inhibitor (Ki=40 nM). Et-29 Chemical Structure
  19. GC10635 EX 527 (SEN0014196)

    EX-527,SIRT1 Inhibitor III,SEN0014196,EX527, Selisistat

    EX 527 (SEN0014196), as a SIRT1-selective inhibitor, inhibits Sirt1 ～100-fold more potently than Sirt2 and Sirt3 and has no effect on Sirt5′s deacetylation activit.

     EX 527 (SEN0014196) Chemical Structure
  20. GC17126 EX-527 R-enantiomer

    (R)-EX-527

     EX-527 R-enantiomer ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM. EX-527 R-enantiomer Chemical Structure
  21. GC13417 EX-527 S-enantiomer EX-527 S-enantiomer ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM. EX-527 S-enantiomer Chemical Structure
  22. GN10030 Fisetin

    CI-75620, NSC 407010, NSC 656275

     Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities. Fisetin Chemical Structure
  23. GC71830 Fisetin quarterhydrate Fisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects. Fisetin quarterhydrate Chemical Structure
  24. GC40900 Ganoderic Acid D Ganoderic acid D is an oxygenated triterpenoid that has been found in G. Ganoderic Acid D Chemical Structure
  25. GC60172 Gardenia yellow Gardenia yellow is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent. Gardenia yellow Chemical Structure
  26. GN10473 Ginkgolide C

    BN 52022, 1,7-dihydroxy Ginkgolide A

     Ginkgolide C Chemical Structure
  27. GC14755 Inauhzin

    INZ

     SIRT1 inhibitor Inauhzin Chemical Structure
  28. GC14686 JFD00244

    BML-266

     inhibitor of SIRT2 JFD00244 Chemical Structure
  29. GC13062 JGB1741

    ILS-JGB-1741

     SIRT1 inhibitor JGB1741 Chemical Structure
  30. GC73903 MC3138 MC3138 is a selective SIRT5 activator. MC3138 Chemical Structure
  31. GC34431 MC3482 MC3482 is a specific sirtuin5 (SIRT5) inhibitor. MC3482 Chemical Structure
  32. GC65581 MIND4-19 MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM. MIND4-19 Chemical Structure
  33. GN10347 Nicotinamide (Vitamin B3)

    Niacinamide, Nicotinic Acid Amide, NSC 13128, NSC 27452, Vitamin B3 Amide

     Nicotinamide (Vitamin B3) is an amide derivative of vitamin B3 that can inhibit the activity of SIRT1 (IC50: 50-180 μM) and SIRT2 (IC50: 2 μM). Nicotinamide can also increase the levels of NAD+, ATP, and ROS in cells . Nicotinamide (Vitamin B3) Chemical Structure
  34. GC44401 Nicotinamide riboside Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, is converted to bioavailable NAD+, via nicotinamide riboside kinase (NRK) and NMNAT, or by the action of nucleoside phosphorylase and NAM salvage. Nicotinamide riboside Chemical Structure
  35. GC36738 Nicotinamide riboside chloride

    A nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin

     Nicotinamide riboside chloride Chemical Structure
  36. GC71615 Nicotinamide-13C6 Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide-13C6 Chemical Structure
  37. GC32745 OSS_128167

    OSS_128167 is a potent selective silencing regulatory protein 6 (SIRT6) inhibitor with an IC50 of 89 μM. 

     OSS_128167 Chemical Structure
  38. GC33418 PROTAC Sirt2 Degrader-1 PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM). PROTAC Sirt2 Degrader-1 Chemical Structure
  39. GC14553 Resveratrol

    (E)Resveratrol

     Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin. Resveratrol Chemical Structure
  40. GC72827 RK-9123016 RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 Chemical Structure
  41. GC14817 Salermide SIRT1 and SIRT2 inhibitor Salermide Chemical Structure
  42. GC39435 Scopolin

    NSC 404560

     Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots. Scopolin Chemical Structure
  43. GC38491 SirReal2 A selective SIRT2 inhibitor SirReal2 Chemical Structure
  44. GC13942 SirReal2 Sirt2 inhibitor SirReal2 Chemical Structure
  45. GC30733 SIRT-IN-1 SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. SIRT-IN-1 Chemical Structure
  46. GC30693 SIRT-IN-2 SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. SIRT-IN-2 Chemical Structure
  47. GC61279 SIRT-IN-3 SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively). SIRT-IN-3 Chemical Structure
  48. GC69897 SIRT1-IN-2

    SIRT1-IN-2 (compound 3h) is an effective and selective inhibitor of SIRT1 (Silent Information Regulator Factor 1), with an IC50 of 1.6 μM.

     SIRT1-IN-2 Chemical Structure
  49. GC11716 SIRT1/2 Inhibitor IV

    Cambinol,NSC 112546,SIRT1 Inhibitor II,SIRT2 Inhibitor VI

     SIRT1/2 Inhibitor IV is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. SIRT1/2 Inhibitor IV is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). SIRT1/2 Inhibitor IV Chemical Structure
  50. GC17145 SIRT1/2 Inhibitor IV

    SIRT1 and SIRT2 inhibitor

     SIRT1/2 Inhibitor IV Chemical Structure
  51. GC30922 SIRT2 Inhibitor II (AK-1) SIRT2 Inhibitor II (AK-1) is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM. SIRT2 Inhibitor II (AK-1) Chemical Structure
  52. GC34785 Sirt2-IN-1 Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM. Sirt2-IN-1 Chemical Structure
  53. GC66026 SIRT2-IN-9 SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer. SIRT2-IN-9 Chemical Structure
  54. GC30251 SIRT5 inhibitor SIRT5 inhibitor is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. SIRT5 inhibitor Chemical Structure
  55. GC69898 SIRT5 inhibitor 3

    SIRT5 inhibitor 3 (compound 46) is an effective and competitive inhibitor of SIRT5, with an IC50 of 5.9 μM. It can inhibit the deacetylation activity of SIRT5. SIRT5 inhibitor 3 can be used for research on cancer and neurodegenerative diseases.

     SIRT5 inhibitor 3 Chemical Structure
  56. GC72775 SIRT6-IN-2 SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 Chemical Structure
  57. GC14945 Sirtinol

    Sir Two Inhibitor Naphthol

     Inhibitor of sirtuin deacetylases Sirtinol Chemical Structure
  58. GC30204 Sirtuin modulator 1 A SIRT1 activator Sirtuin modulator 1 Chemical Structure
  59. GC65030 Sirtuin modulator 2 Sirtuin modulator 2 (Compound 132) is a sirtuin modulator with an ED50 equal or less than 50 μM. Sirtuin modulator 2 Chemical Structure
  60. GC67778 Sirtuin modulator 3 Sirtuin modulator 3 Chemical Structure
  61. GC73703 Sirtuin-1 inhibitor 1 Sirtuin-1 inhibitor 1 (Compound 8) is an inhibitor of Sirtuin-1 that plays important roles in obesity-induced diabetes and aging-related diseases. Sirtuin-1 inhibitor 1 Chemical Structure
  62. GC10555 Splitomicin Inhibitor of yeast Sir2p Splitomicin Chemical Structure
  63. GC65019 SRT 1460 SRT 1460, a potent Sirtuin-1 (SIRT1) activator with an EC1.5 value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues. SRT 1460 Chemical Structure
  64. GC37677 SRT 1720 SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively. SRT 1720 Chemical Structure
  65. GC69950 SRT 1720 dihydrochloride

    SRT 1720 dihydrochloride is a selective and orally active SIRT1 activator with an EC50 of 0.10 μM, showing weaker effects on SIRT2 and SIRT3.

     SRT 1720 dihydrochloride Chemical Structure
  66. GC64946 SRT 2183 SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels. SRT 2183 Chemical Structure
  67. GC17101 SRT1720 HCl

    SRT-1720,SRT 1720,SRT 1720 Hydrochloride

     SRT1720 HCl is an activator of SIRT1 (EC1.5 = 0.16 µM and maximum activation = 781%), a NAD+-dependent protein and histone deacetylase that plays an important role in numerous biologic processes. SRT1720 HCl Chemical Structure
  68. GC15109 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a highly selective small-molecule activator of Sirtuin 1 (SIRT1), penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and protected against diabetes-induced aortic endothelial dysfunction. SRT2104 (GSK2245840) Chemical Structure
  69. GC70538 Tanshindiol C Tanshindiol C is a S-adenosylmethionine-competitive EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 0.55 μM for inhibiting the methyltransferase activity. Tanshindiol C Chemical Structure
  70. GC14165 Tenovin-1 A small molecule activator of p53 Tenovin-1 Chemical Structure
  71. GC12337 Tenovin-3

    Tenovin 3;Tenovin3

     p53 activator Tenovin-3 Chemical Structure
  72. GC16436 Tenovin-6 SIRT inhibitor and p53 activator Tenovin-6 Chemical Structure
  73. GC37761 Tenovin-6 Hydrochloride Tenovin-6 Hydrochloride, an analog of Tenovin-1, is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 Hydrochloride Chemical Structure
  74. GC17724 Thiomyristoyl

    TM

     A potent and selective SIRT2 inhibitor Thiomyristoyl Chemical Structure
  75. GC17704 Triacetyl Resveratrol

    Resveratrol triacetate, Triacetylresveratrol, 3,5,4'-Tri-O-acetylresveratrol

     Cell-permeable resveratrol prodrug Triacetyl Resveratrol Chemical Structure
  76. GC34849 UBCS039 UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM. UBCS039 Chemical Structure
  77. GC71350 Z26395438 Z26395438 (compound 1) is a potent Sirtuin-1 inhibitor, with an IC50 value of 1.6 μM. Z26395438 Chemical Structure

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