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Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

  1. Cat.No. Product Name Information
  2. GC19013 3-TYP A SIRT3 inhibitor
  3. GC17922 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor
  4. GC17881 AGK 2 SIRT2 inhibitor, potent and selective
  5. GC15931 AGK7 cell-permeable, selective inhibitor of SIRT2
  6. GN10413 Agrimol B Extracted from hairyvein agrimony;Store the product in sealed, cool and dry condition
  7. GC10676 AK-7

    selective and brain-permeable SIRT2 inhibitor

  8. GC18228 CAY10602 Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD-dependent protein deacetylase that has been implicated in cell metabolism, differentiation, stress and DNA damage response, and the control of multidrug resistance in cancer.
  9. GC34187 Dihydrocoumarin (Hydrocoumarin)
  10. GC10635 EX 527 (SEN0014196) A SIRT1 inhibitor
  11. GC17126 EX-527 R-enantiomer SIRT1 inhibitor
  12. GC13417 EX-527 S-enantiomer SIRT1 inhibitor
  13. GN10030 Fisetin Extracted from Rhus succedanea L;Store the product in sealed, cool and dry condition
  14. GC40900 Ganoderic Acid D Ganoderic acid D is an oxygenated triterpenoid that has been found in G.
  15. GN10473 Ginkgolide C Extracted from Ginkgo biloba Leaf P.E.;Suitability:Ethyl acetate,methanol,ethanol,two sulfoxide;Store the product in sealed,cool and dry condition
  16. GC14755 Inauhzin SIRT1 inhibitor
  17. GC14686 JFD00244 inhibitor of SIRT2
  18. GC13062 JGB1741 SIRT1 inhibitor
  19. GC34431 MC3482
  20. GN10347 Nicotinamide PARP-1 inhibitor
  21. GC44401 Nicotinamide riboside A riboside form of nicotinamide

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