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GPCR/G protein

Products for  GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC30996 Alvameline (Lu 25-109) Alvameline (Lu 25-109) (Lu25-109) is a partial M1 agonist and M2/M3 antagonist. Alvameline (Lu 25-109)  Chemical Structure
  3. GC10891 Alverine Citrate Drug used for functional gastrointestinal disorders Alverine Citrate  Chemical Structure
  4. GC32208 ALX 40-4C ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. ALX 40-4C  Chemical Structure
  5. GC34386 ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. ALX 40-4C Trifluoroacetate  Chemical Structure
  6. GC14908 Alytesin Amphibian bombesin-like peptide Alytesin  Chemical Structure
  7. GC16480 AM 281 A CB1 antagonist AM 281  Chemical Structure
  8. GC15908 AM-095 free base A selective LPA1 receptor antagonist AM-095 free base  Chemical Structure
  9. GC31607 AM-1638 AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM. AM-1638  Chemical Structure
  10. GC34464 AM-4668 AM-4668 is a GPR40 agonist for type 2 diabetes. AM-4668  Chemical Structure
  11. GC62835 AM-6538 AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM-6538  Chemical Structure
  12. GC15220 AM095 A selective LPA1 receptor antagonist AM095  Chemical Structure
  13. GC15414 AM1241 Cannabinoid CB2 receptor agonist,potent and selective AM1241  Chemical Structure
  14. GC31718 AM211 (AM211 free acid) AM211 (AM211 free acid) is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively. AM211 (AM211 free acid)  Chemical Structure
  15. GC15717 AM251

    A potent CB1 antagonist

    AM251  Chemical Structure
  16. GC15093 AM4113 AM4113 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5 nM. AM4113  Chemical Structure
  17. GC10147 AM630

    An inverse agonist at CB2 and partial agonist at CB1 receptors

    AM630  Chemical Structure
  18. GC14661 AM6545 CB1 selective neutral antagonist AM6545  Chemical Structure
  19. GC13476 AM966 A potent and selective LPA1 receptor antagonist AM966  Chemical Structure
  20. GC17184 Ambrisentan ETA-receptor antagonist Ambrisentan  Chemical Structure
  21. GC31815 Ambutonium bromide (BL700) Ambutonium bromide (BL700) is an acetylcholine antagonist. Ambutonium bromide (BL700)  Chemical Structure
  22. GC42782 Amcinonide Amcinonide is a synthetic corticosteroid. Amcinonide  Chemical Structure
  23. GC10473 AMD 3465 CXCR4 antagonist,potent and selective AMD 3465  Chemical Structure
  24. GC16706 AMD 3465 hexahydrobromide potent, selective CXCR4 antagonist AMD 3465 hexahydrobromide  Chemical Structure
  25. GC12196 AMD-070 A CXCR4 antagonist AMD-070  Chemical Structure
  26. GC17018 AMD-070 hydrochloride CXCR4 antagonist,potent and selective AMD-070 hydrochloride  Chemical Structure
  27. GC31929 Amebucort Amebucort is a synthetic glucocorticoid corticosteroid, may used for the research of inflammatory disorders. Amebucort  Chemical Structure
  28. GC32058 Amelubant (BIIL 284) Amelubant (BIIL 284) (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes. Amelubant (BIIL 284)  Chemical Structure
  29. GC32516 Amezinium methylsulfate (Amezinium metilsulfate) Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Amezinium methylsulfate (Amezinium metilsulfate)  Chemical Structure
  30. GC11939 AMG 487

    AMG 487 is an oral, selective chemokine receptor 3 (CXCR3) antagonist that inhibits CXCL10 and CXCL11 binding to CXCR3 with IC50 values of 8.0 and 8.2 nM, respectively.

    AMG 487  Chemical Structure
  31. GC19030 AMG 837 AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents AMG 837  Chemical Structure
  32. GC35313 AMG 837 calcium hydrate AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 calcium hydrate  Chemical Structure
  33. GC50333 AMG 837 hemicalcium salt AMG 837 hemicalcium salt is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 hemicalcium salt  Chemical Structure
  34. GC35314 AMG 837 sodium salt AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. AMG 837 sodium salt  Chemical Structure
  35. GC50240 AMG 853 AMG 853 (AMG 853) is a phenylacetic acid derivative. AMG 853  Chemical Structure
  36. GC31830 AMG-009 AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively. AMG-009  Chemical Structure
  37. GC19546 AMG-510 racemate Sotorasib (AMG-510) racemate is the racemate of Sotorasib (AMG-510). AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. AMG-510 racemate  Chemical Structure
  38. GC32548 Aminaftone (Aminaftone) Aminaftone (Aminaftone), a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene. Aminaftone (Aminaftone)  Chemical Structure
  39. GC19031 Amiselimod hydrochloride Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride  Chemical Structure
  40. GC33983 Amitraz (BTS-27419) Amitraz (BTS-27419) is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis. Amitraz (BTS-27419)  Chemical Structure
  41. GC13723 Amitriptyline HCl Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl  Chemical Structure
  42. GC63922 AMN082 free base AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base  Chemical Structure
  43. GC31229 AMPD2 inhibitor 1

    AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.

    AMPD2 inhibitor 1  Chemical Structure
  44. GC16513 Amylin Amylin, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin  Chemical Structure
  45. GC13253 Anamorelin A small molecule agonist of GHS-R1a Anamorelin  Chemical Structure
  46. GC35337 Anamorelin Fumarate Anamorelin Fumarate is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay. Anamorelin Fumarate  Chemical Structure
  47. GC35338 Anamorelin hydrochloride Anamorelin (RC-1291) hydrochloride is a potent ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay. Anamorelin hydrochloride  Chemical Structure
  48. GC35339 Anandamide An immune modulator in the central nervous system Anandamide  Chemical Structure
  49. GC32582 Ancarolol Ancarolol is a beta-adrenergic blocking agent. Ancarolol  Chemical Structure
  50. GC62843 Angiopeptin TFA Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26?nM and 6.92?nM, respectively. Angiopeptin TFA  Chemical Structure
  51. GP10077 Angiotensin (1-7)

    Ang-(1-7) (H - Asp - Arg - Val - Tyr - Ile - His - Pro - OH) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively[1].

    Angiotensin (1-7)  Chemical Structure
  52. GC61496 Angiotensin (1-7) (acetate) Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin (1-7) (acetate)  Chemical Structure
  53. GA20760 Angiotensin A (1-7) Angiotensin A (1-7), a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Angiotensin A (1-7)  Chemical Structure
  54. GC12671 Angiotensin Fragment 1-7 (acetate) type 1 angiotensin II receptor agonist Angiotensin Fragment 1-7 (acetate)  Chemical Structure
  55. GC61952 Angiotensin I/II (1-6) (TFA) Angiotensin I/II (1-6) TFA contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. Angiotensin I/II (1-6) (TFA)  Chemical Structure
  56. GC35351 Angiotensin II (1-4), human

    Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE).

    Angiotensin II (1-4), human  Chemical Structure
  57. GC35352 Angiotensin II (3-8), human

    Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

    Angiotensin II (3-8), human  Chemical Structure
  58. GC35353 Angiotensin II (3-8), human TFA

    Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT1 receptor.

    Angiotensin II (3-8), human TFA  Chemical Structure
  59. GC42810 Angiotensin II (5-8) (human, rat, mouse) Angiotensin II (5-8) (human, rat, mouse) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Angiotensin II (5-8) (human, rat, mouse)  Chemical Structure
  60. GC35354 Angiotensin II 5-valine

    Angiotensin II 5-valine is an agonist of angiotensin receptor.

    Angiotensin II 5-valine  Chemical Structure
  61. GC60584 Angiotensin II human acetate

    Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system.

    Angiotensin II human acetate  Chemical Structure
  62. GC62844 Angiotensin II human TFA

    Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system.

    Angiotensin II human TFA  Chemical Structure
  63. GC35355 Angiotensin III Angiotensin III  Chemical Structure
  64. GP10110 Angiotensin III (human, mouse) An agonist at AT1 and AT2 receptors Angiotensin III (human, mouse)  Chemical Structure
  65. GC35356 Angiotensin III TFA Angiotensin III TFA  Chemical Structure
  66. GC66025 Angiotensin III, human, mouse TFA Angiotensin III, human, mouse (TFA) is an angiotensin. Angiotensin III, human, mouse TFA  Chemical Structure
  67. GC17736 Anisodamine

    weak antagonist of α1-adrenoceptors

    Anisodamine  Chemical Structure
  68. GC60049 Anisodamine hydrobromide Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide  Chemical Structure
  69. GC15030 ANQ 11125 Motilin receptor antagonist,selective ANQ 11125  Chemical Structure
  70. GC16159 ANR 94 Adenosine A2A-R antagonist ANR 94  Chemical Structure
  71. GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. Ansofaxine hydrochloride (LY03005)  Chemical Structure
  72. GC15253 Antalarmin hydrochloride CRF1 antagonist Antalarmin hydrochloride  Chemical Structure
  73. GC42817 Antileukinate Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. Antileukinate  Chemical Structure
  74. GC35361 Antineoplaston A10 Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer. Antineoplaston A10  Chemical Structure
  75. GC16842 Antisauvagine-30 corticotropin-releasing factor CRF2 receptor antagonist Antisauvagine-30  Chemical Structure
  76. GC38886 Antisauvagine-30 TFA Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA  Chemical Structure
  77. GC35364 AP5 AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5  Chemical Structure
  78. GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. AP521  Chemical Structure
  79. GC16688 APC 366 mast cell tryptase inhibitor,selective and competitive APC 366  Chemical Structure
  80. GC19033 APD597 APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. APD597  Chemical Structure
  81. GC12738 APD668 Potent GPR119 agonist APD668  Chemical Structure
  82. GC10284 Apelin-13 Apelin-13 is a peptide known as the ligand of the G-protein-coupled receptor APJ. Apelin-13  Chemical Structure
  83. GC10961 Apelin-17 (human, bovine) Endogenous apelin receptor agonist Apelin-17 (human, bovine)  Chemical Structure
  84. GC16715 Apelin-36 (human) Endogenous APJ receptor agonist Apelin-36 (human)  Chemical Structure
  85. GC10308 Apelin-36 (rat, mouse) Endogenous APJ receptor agonist Apelin-36 (rat, mouse)  Chemical Structure
  86. GC32336 Aplaviroc (AK 602) Aplaviroc (AK 602) (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Aplaviroc (AK 602)  Chemical Structure
  87. GC62610 Aplaviroc hydrochloride Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. Aplaviroc hydrochloride  Chemical Structure
  88. GC33702 APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist. APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine)  Chemical Structure
  89. GC15200 Aprepitant Substance P (SP) inhibitor Aprepitant  Chemical Structure
  90. GC68320 Aprocitentan D4 Aprocitentan D4  Chemical Structure
  91. GC14944 AR 231453 GPR119 agonist,potent and selective AR 231453  Chemical Structure
  92. GC31291 AR-A 2 (AR-A 000002) AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety. AR-A 2 (AR-A 000002)  Chemical Structure
  93. GC50081 AR-C 118925XX Selective and competitive P2Y2 antagonist AR-C 118925XX  Chemical Structure
  94. GC12914 AR-C 66096 tetrasodium salt P2Y12 antagonist,potent and selective AR-C 66096 tetrasodium salt  Chemical Structure
  95. GC11955 AR-M 1896 Selective GAL2 agonist AR-M 1896  Chemical Structure
  96. GC42831 AR420626

    Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).

    AR420626  Chemical Structure
  97. GC18435 Arachidonoyl 2'-Chloroethylamide A potent and selective CB1 receptor agonist Arachidonoyl 2'-Chloroethylamide  Chemical Structure
  98. GC16826 Arachidonoyl amide CB1 receptor agonist Arachidonoyl amide  Chemical Structure
  99. GC18097 Arachidonoyl Serinol CB1 receptor agonist Arachidonoyl Serinol  Chemical Structure
  100. GC11849 Arachidonyl serotonin Arachidonyl serotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 μM. Arachidonyl serotonin  Chemical Structure
  101. GC35381 Arborine Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure. Arborine  Chemical Structure

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