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GPCR/G protein

Products for  GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC10600 1,3-Dipropyl-8-phenylxanthine

    A1 adenosine antagonist

    1,3-Dipropyl-8-phenylxanthine  Chemical Structure
  3. GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors 1-(1-Naphthyl) piperazine (hydrochloride)  Chemical Structure
  4. GC16031 1-(3-Chlorophenyl)piperazine (hydrochloride)

    5-HT2C/2B receptor agonist/partial agonist

    1-(3-Chlorophenyl)piperazine (hydrochloride)  Chemical Structure
  5. GC17913 1-Deazaadenosine adenosine deaminase inhibitor 1-Deazaadenosine  Chemical Structure
  6. GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective 1-Methylpsilocin  Chemical Structure
  7. GC42011 1-Oleoyl Lysophosphatidic Acid

    A potent LPA receptor agonist

    1-Oleoyl Lysophosphatidic Acid  Chemical Structure
  8. GC15140 1-Oleoyl lysophosphatidic acid sodium salt 1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) sodium, a potent bioactive phospholipid, is a LPA receptor activator. 1-Oleoyl lysophosphatidic acid sodium salt  Chemical Structure
  9. GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist 1-Phenylbiguanide hydrochloride  Chemical Structure
  10. GC10821 11-keto-β-Boswellic Acid 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid  Chemical Structure
  11. GC41883 12(S)-HHTrE 12(S)-HHTrE (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12(S)-HHTrE  Chemical Structure
  12. GC16693 13Z,16Z-Docosadienoic Acid FFAR4(GPR120) agonist 13Z,16Z-Docosadienoic Acid  Chemical Structure
  13. GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α  Chemical Structure
  14. GC11133 16,16-Dimethyl Prostaglandin E2

    derivative of prostaglandin E2

    16,16-Dimethyl Prostaglandin E2  Chemical Structure
  15. GC32770 1A-116 1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo. 1A-116  Chemical Structure
  16. GC17757 1H-1-ethyl Candesartan Cilexetil selective angiotensin II type 1 receptor (AT1) antagonist 1H-1-ethyl Candesartan Cilexetil  Chemical Structure
  17. GC11112 2'-MeCCPA A1 adenosine receptor agonist 2'-MeCCPA  Chemical Structure
  18. GC66678 2-(3-Trifluoromethylphenyl)glycine hydrochloride 2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research. 2-(3-Trifluoromethylphenyl)glycine hydrochloride  Chemical Structure
  19. GC30561 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide  Chemical Structure
  20. GC16403 2-Arachidonoyl Glycerol

    An endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2

    2-Arachidonoyl Glycerol  Chemical Structure
  21. GC10116 2-chloro-3-Deazaadenosine adenosine receptors agonist 2-chloro-3-Deazaadenosine  Chemical Structure
  22. GC11665 2-Chloro-N6-cyclopentyladenosine adenosine A1 receptor agonist, potent and selective 2-Chloro-N6-cyclopentyladenosine  Chemical Structure
  23. GC15111 2-Chloroadenosine adenosine receptor agonist 2-Chloroadenosine  Chemical Structure
  24. GC17503 2-Cl-IB-MECA 2-Cl-IB-MECA (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). 2-Cl-IB-MECA displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. 2-Cl-IB-MECA  Chemical Structure
  25. GC14445 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine nonpeptidic angiotensin II receptor antagonist 2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine  Chemical Structure
  26. GC17218 2-fluoro Palmitic Acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase 2-fluoro Palmitic Acid  Chemical Structure
  27. GC14690 2-Iodomelatonin melatonin agonist 2-Iodomelatonin  Chemical Structure
  28. GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT  Chemical Structure
  29. GC11176 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-hydroxytryptamine hydrochloride  Chemical Structure
  30. GC64027 2-Methylthio-AMP 2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP  Chemical Structure
  31. GC62783 2-Methylthio-AMP diTEA 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA  Chemical Structure
  32. GC60016 2-Methylthioadenosine diphosphate trisodium An agonist of P2Y receptors 2-Methylthioadenosine diphosphate trisodium  Chemical Structure
  33. GC16412 2-MPMDQ α1-adrenoceptor antagonist,potent and selective 2-MPMDQ  Chemical Structure
  34. GC40406 2-Oleoyl Glycerol

    2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol.

    2-Oleoyl Glycerol  Chemical Structure
  35. GC16196 2-Palmitoylglycerol Endogenous fatty acid glycerol ester 2-Palmitoylglycerol  Chemical Structure
  36. GC11288 2-Phenylmelatonin 2-Phenylmelatonin is a high affinity melatonin (MT) membrane receptor agonist. 2-Phenylmelatonin  Chemical Structure
  37. GC13695 2-PMDQ α1-adrenoceptor antagonist 2-PMDQ  Chemical Structure
  38. GC14753 2-ThioUTP tetrasodium salt P2Y2 agonist 2-ThioUTP tetrasodium salt  Chemical Structure
  39. GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor 2-[1-(4-Piperonyl)piperazinyl]benzothiazole  Chemical Structure
  40. GC60467 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone? 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione  Chemical Structure
  41. GC63737 21-Desacetyldeflazacort-D5 21-Desacetyldeflazacort-D5  Chemical Structure
  42. GC11427 26RFa natural ligand of the orphan receptor GPR103 26RFa  Chemical Structure
  43. GC15232 3,5-DHBA hydroxycarboxylic acid receptor 1 (HCA1) agonist 3,5-DHBA  Chemical Structure
  44. GC15569 3-AQC 5-HT3 antagonist 3-AQC  Chemical Structure
  45. GC16689 3-chloro-5-hydroxy BA 3-chloro-5-hydroxy BA is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-chloro-5-hydroxy BA  Chemical Structure
  46. GC68328 3-Hydroxy agomelatine-d3 3-Hydroxy agomelatine-d3  Chemical Structure
  47. GN10169 3-Hydroxy-4-methoxycinnamic acid 3-Hydroxy-4-methoxycinnamic acid  Chemical Structure
  48. GC10073 3-MPPI ligand for adrenergic α1 receptor 3-MPPI  Chemical Structure
  49. GC17149 4-CMTB FFA2 agonist 4-CMTB  Chemical Structure
  50. GC39678 4-Deoxypyridoxine 5'-phosphate A vitamin B6 analog and an inhibitor of S1P lyase 4-Deoxypyridoxine 5'-phosphate  Chemical Structure
  51. GC68327 4-Hydroxyatomoxetine-d3 4-Hydroxyatomoxetine-d3  Chemical Structure
  52. GC64116 4-Hydroxypropranolol-d7 4-Hydroxypropranolol-d7  Chemical Structure
  53. GC17723 4-IBP σ1 agonist 4-IBP  Chemical Structure
  54. GC42460 4-Nitrophenyl Phenylphosphonate 4-Nitrophenyl phenylphosphonate is a substrate for 5'-nucleotide phosphodiesterases. 4-Nitrophenyl Phenylphosphonate  Chemical Structure
  55. GC16186 4-P-PDOT

    Melatonin receptor antagonist

    4-P-PDOT  Chemical Structure
  56. GC13357 4-PPBP maleate σ ligand and NR1a/2B NMDA receptors antagonist 4-PPBP maleate  Chemical Structure
  57. GC17100 4-Quinolone-3-Carboxamide CB2 Ligand ligand of the CB2 receptor 4-Quinolone-3-Carboxamide CB2 Ligand  Chemical Structure
  58. GC15850 4-Quinolone-3-Carboxamide Furan CB2 Agonist 4-Quinolone-3-Carboxamide Furan CB2 Agonist is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. 4-Quinolone-3-Carboxamide Furan CB2 Agonist  Chemical Structure
  59. GC16040 4F 4PP oxalate 5-HT2A antagonist 4F 4PP oxalate  Chemical Structure
  60. GC11002 5'-(N-Cyclopropyl)carboxamidoadenosine adenosine A2 receptor agonist 5'-(N-Cyclopropyl)carboxamidoadenosine  Chemical Structure
  61. GC14814 5-Carboxamidotryptamine maleate 5-HT1 agonist 5-Carboxamidotryptamine maleate  Chemical Structure
  62. GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. 5-HT1A modulator 1  Chemical Structure
  63. GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity. 5-HT2 antagonist 1  Chemical Structure
  64. GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1  Chemical Structure
  65. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1  Chemical Structure
  66. GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT3 antagonist 1  Chemical Structure
  67. GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. 5-HT3 antagonist 2  Chemical Structure
  68. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5  Chemical Structure
  69. GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. 5-HT3-In-1  Chemical Structure
  70. GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 5-HT4 antagonist 1  Chemical Structure
  71. GC14801 5-Iodotubercidin An adenosine kinase inhibitor 5-Iodotubercidin  Chemical Structure
  72. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride  Chemical Structure
  73. GC35168 5-O-Demethylnobiletin 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin  Chemical Structure
  74. GC13588 5-OMe-UDP trisodium salt

    Potent P2Y6 agonist

    5-OMe-UDP trisodium salt  Chemical Structure
  75. GC17719 5-trans U-46619 Prostaglandin E synthase inhibitor 5-trans U-46619  Chemical Structure
  76. GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM. 5HT6-ligand-1  Chemical Structure
  77. GC42587 6α-Methylprednisolone 21-hemisuccinate 6α-Methylprednisolone 21-hemisuccinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent. 6α-Methylprednisolone 21-hemisuccinate  Chemical Structure
  78. GC12014 6-Chloromelatonin

    melatonin agonist

    6-Chloromelatonin  Chemical Structure
  79. GC11350 6-OAU synthetic agonist for GPR84 6-OAU  Chemical Structure
  80. GC15478 6H05 K-Ras inhibitor 6H05  Chemical Structure
  81. GC60533 6H05 (TFA) An allosteric inhibitor of oncogenic K-Ras(G12C) 6H05 (TFA)  Chemical Structure
  82. GC34427 6H05 trifluoroacetate (K-Ras inhibitor) 6H05 trifluoroacetate (K-Ras inhibitor)  Chemical Structure
  83. GC35185 7,4'-Dihydroxyflavone 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone  Chemical Structure
  84. GC14433 7α,25-dihydroxy Cholesterol A GPR183 agonist 7α,25-dihydroxy Cholesterol  Chemical Structure
  85. GC11199 8-(3-Chlorostyryl)caffeine 8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist. 8-(3-Chlorostyryl)caffeine  Chemical Structure
  86. GC13274 8-Aminoadenine

    Adenine receptor agonist

    8-Aminoadenine  Chemical Structure
  87. GC50588 8-Azaadenosine ADAR1 (adenosine deaminases acting on double-stranded RNA) inhibitor; inhibits leukemia stem cell self-renewal 8-Azaadenosine  Chemical Structure
  88. GC50354 8-Cyclopentyl-1,3-dimethylxanthine High affinity adenosine A1 receptor antagonist 8-Cyclopentyl-1,3-dimethylxanthine  Chemical Structure
  89. GC16020 8-M-PDOT Melatonin receptor agonist 8-M-PDOT  Chemical Structure
  90. GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5). 8-OH-DPAT (8-Hydroxy-DPAT)  Chemical Structure
  91. GC50247 A 127722 Highly potent, selective ETA antagonist; orally bioavailable A 127722  Chemical Structure
  92. GC14527 A 61603 hydrobromide A 61603 hydrobromide is a selective α1A-adrenergic receptor agonist. A 61603 hydrobromide  Chemical Structure
  93. GC11004 A 779 angiotensin-(1-7)/ Mas receptor antagonist A 779  Chemical Structure
  94. GC13027 A 80426 mesylate α2-adrenoceptor antagonist and 5-HT uptake inhibitor A 80426 mesylate  Chemical Structure
  95. GC60544 A-192621 A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621  Chemical Structure
  96. GC16913 A-71623 CCK1 agonist A-71623  Chemical Structure
  97. GC18199 A-836339 A-836339 is a synthetic cannabinoid (CB) which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 receptor (Ki = 270 nM). A-836339  Chemical Structure
  98. GC42664 A-971432

    A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 μM, respectively).

    A-971432  Chemical Structure
  99. GC30918 A2A receptor antagonist 1 A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM, respectively. A2A receptor antagonist 1  Chemical Structure
  100. GC30987 A2AR-agonist-1 An agonist of adenosine A2A receptor and inhibitor of ENT1 A2AR-agonist-1  Chemical Structure
  101. GC38104 A2aR/A2bR antagonist-1 A2aR/A2bR antagonist-1 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. A2aR/A2bR antagonist-1  Chemical Structure

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