GPCR/G protein
- Neuropeptide FF/AF Receptors(43)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(415)
- Acetylcholine(19)
- Adenosine Deaminase(12)
- Adenosine Receptor(133)
- Adenosine Kinase(5)
- Adiponectin Receptor(4)
- Adrenergic Receptor(404)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(110)
- Bombesin Receptors(22)
- Bradykinin Receptors(27)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(137)
- Calcimimetic Agent(3)
- CaSR(24)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(79)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(82)
- CysLT1 receptor(1)
- Endothelin Receptor(50)
- EP1 Receptor(3)
- EP4 Receptor(5)
- ERRγ(2)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(20)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(22)
- GIP Receptor(5)
- Glucagon Receptor(66)
- Glucocorticoid Receptor(87)
- GLUT1(2)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(13)
- GPR109A(4)
- GPR119(11)
- GPR120(12)
- GPR35(8)
- GPR44(1)
- GPR55(10)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(55)
- LPA Receptor(15)
- LPL Receptor(60)
- LTD4 Receptor(2)
- mGluR (115)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(49)
- Melatonin Receptors(23)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(21)
- NK2 Receptors(7)
- NK3 Receptor(8)
- NOP Receptor(22)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(42)
- Oxytocin Receptors(21)
- P2Y Receptor(55)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(15)
- PGD2 Receptor(2)
- Prostaglandin Receptor(168)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(4)
- S1P receptor(9)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(34)
- Sigma Receptor(54)
- Vasopressin Receptor(33)
- 17,20-lyase(7)
- Ras(118)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(5)
- TSH Receptor(10)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(22)
- GPR84(5)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(4)
- CRFR(21)
- RGS Protein(7)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(23)
- GPR139(3)
- mAChR(179)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(72)
- cGMP(18)
- GRK(1)
Products for GPCR/G protein
- Cat.No. Product Name Information
- GC30996 Alvameline (Lu 25-109) Alvameline (Lu 25-109) (Lu25-109) is a partial M1 agonist and M2/M3 antagonist.
- GC10891 Alverine Citrate Drug used for functional gastrointestinal disorders
- GC32208 ALX 40-4C ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.
- GC34386 ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.
- GC14908 Alytesin Amphibian bombesin-like peptide
- GC16480 AM 281 A CB1 antagonist
- GC15908 AM-095 free base A selective LPA1 receptor antagonist
- GC31607 AM-1638 AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM.
- GC34464 AM-4668 AM-4668 is a GPR40 agonist for type 2 diabetes.
- GC62835 AM-6538 AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist.
- GC15220 AM095 A selective LPA1 receptor antagonist
- GC15414 AM1241 Cannabinoid CB2 receptor agonist,potent and selective
- GC31718 AM211 (AM211 free acid) AM211 (AM211 free acid) is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.
-
GC15717
AM251
A potent CB1 antagonist
- GC15093 AM4113 AM4113 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5 nM.
-
GC10147
AM630
An inverse agonist at CB2 and partial agonist at CB1 receptors
- GC14661 AM6545 CB1 selective neutral antagonist
- GC13476 AM966 A potent and selective LPA1 receptor antagonist
- GC17184 Ambrisentan ETA-receptor antagonist
- GC31815 Ambutonium bromide (BL700) Ambutonium bromide (BL700) is an acetylcholine antagonist.
- GC42782 Amcinonide Amcinonide is a synthetic corticosteroid.
- GC10473 AMD 3465 CXCR4 antagonist,potent and selective
- GC16706 AMD 3465 hexahydrobromide potent, selective CXCR4 antagonist
- GC12196 AMD-070 A CXCR4 antagonist
- GC17018 AMD-070 hydrochloride CXCR4 antagonist,potent and selective
- GC31929 Amebucort Amebucort is a synthetic glucocorticoid corticosteroid, may used for the research of inflammatory disorders.
- GC32058 Amelubant (BIIL 284) Amelubant (BIIL 284) (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM in vital cells and membranes.
- GC32516 Amezinium methylsulfate (Amezinium metilsulfate) Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.
-
GC11939
AMG 487
AMG 487 is an oral, selective chemokine receptor 3 (CXCR3) antagonist that inhibits CXCL10 and CXCL11 binding to CXCR3 with IC50 values of 8.0 and 8.2 nM, respectively.
- GC19030 AMG 837 AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents
- GC35313 AMG 837 calcium hydrate AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1.
- GC50333 AMG 837 hemicalcium salt AMG 837 hemicalcium salt is a potent, orally bioavailable and partial agonist of GPR40/FFA1.
- GC35314 AMG 837 sodium salt AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
- GC50240 AMG 853 AMG 853 (AMG 853) is a phenylacetic acid derivative.
- GC31830 AMG-009 AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.
- GC19546 AMG-510 racemate Sotorasib (AMG-510) racemate is the racemate of Sotorasib (AMG-510). AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
- GC32548 Aminaftone (Aminaftone) Aminaftone (Aminaftone), a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene.
- GC19031 Amiselimod hydrochloride Amiselimod hydrochloride is a novel sphingosine 1-phosphate receptor-1 (S1P1) modulator, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators.
- GC33983 Amitraz (BTS-27419) Amitraz (BTS-27419) is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.
- GC13723 Amitriptyline HCl Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively.
- GC63922 AMN082 free base AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain.
-
GC31229
AMPD2 inhibitor 1
AMPD2 inhibitor 1 is an adenosine monophosphate deaminase 2 (AMPD2) inhibitor, used in the research of sugar craving, salt craving, umami craving, and addictions including drug, tobacco, nicotine and alcohol addictions.
- GC16513 Amylin Amylin, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis.
- GC13253 Anamorelin A small molecule agonist of GHS-R1a
- GC35337 Anamorelin Fumarate Anamorelin Fumarate is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
- GC35338 Anamorelin hydrochloride Anamorelin (RC-1291) hydrochloride is a potent ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
- GC35339 Anandamide An immune modulator in the central nervous system
- GC32582 Ancarolol Ancarolol is a beta-adrenergic blocking agent.
- GC62843 Angiopeptin TFA Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26?nM and 6.92?nM, respectively.
-
GP10077
Angiotensin (1-7)
Ang-(1-7) (H - Asp - Arg - Val - Tyr - Ile - His - Pro - OH) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively[1].
- GC61496 Angiotensin (1-7) (acetate) Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells.
- GA20760 Angiotensin A (1-7) Angiotensin A (1-7), a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD.
- GC12671 Angiotensin Fragment 1-7 (acetate) type 1 angiotensin II receptor agonist
- GC61952 Angiotensin I/II (1-6) (TFA) Angiotensin I/II (1-6) TFA contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.
-
GC35351
Angiotensin II (1-4), human
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE).
-
GC35352
Angiotensin II (3-8), human
Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.
-
GC35353
Angiotensin II (3-8), human TFA
Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT1 receptor.
- GC42810 Angiotensin II (5-8) (human, rat, mouse) Angiotensin II (5-8) (human, rat, mouse) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.
-
GC35354
Angiotensin II 5-valine
Angiotensin II 5-valine is an agonist of angiotensin receptor.
-
GC60584
Angiotensin II human acetate
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system.
-
GC62844
Angiotensin II human TFA
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system.
- GC35355 Angiotensin III
- GP10110 Angiotensin III (human, mouse) An agonist at AT1 and AT2 receptors
- GC35356 Angiotensin III TFA
- GC66025 Angiotensin III, human, mouse TFA Angiotensin III, human, mouse (TFA) is an angiotensin.
-
GC17736
Anisodamine
weak antagonist of α1-adrenoceptors
- GC60049 Anisodamine hydrobromide Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist.
- GC15030 ANQ 11125 Motilin receptor antagonist,selective
- GC16159 ANR 94 Adenosine A2A-R antagonist
- GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively.
- GC15253 Antalarmin hydrochloride CRF1 antagonist
- GC42817 Antileukinate Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2.
- GC35361 Antineoplaston A10 Antineoplaston A10, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
- GC16842 Antisauvagine-30 corticotropin-releasing factor CRF2 receptor antagonist
- GC38886 Antisauvagine-30 TFA Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist.
- GC35364 AP5 AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM).
- GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
- GC16688 APC 366 mast cell tryptase inhibitor,selective and competitive
- GC19033 APD597 APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.
- GC12738 APD668 Potent GPR119 agonist
- GC10284 Apelin-13 Apelin-13 is a peptide known as the ligand of the G-protein-coupled receptor APJ.
- GC10961 Apelin-17 (human, bovine) Endogenous apelin receptor agonist
- GC16715 Apelin-36 (human) Endogenous APJ receptor agonist
- GC10308 Apelin-36 (rat, mouse) Endogenous APJ receptor agonist
- GC32336 Aplaviroc (AK 602) Aplaviroc (AK 602) (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
- GC62610 Aplaviroc hydrochloride Aplaviroc (AK 602) hydrochloride, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
- GC33702 APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist.
- GC15200 Aprepitant Substance P (SP) inhibitor
- GC68320 Aprocitentan D4
- GC14944 AR 231453 GPR119 agonist,potent and selective
- GC31291 AR-A 2 (AR-A 000002) AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety.
- GC50081 AR-C 118925XX Selective and competitive P2Y2 antagonist
- GC12914 AR-C 66096 tetrasodium salt P2Y12 antagonist,potent and selective
- GC11955 AR-M 1896 Selective GAL2 agonist
-
GC42831
AR420626
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).
- GC18435 Arachidonoyl 2'-Chloroethylamide A potent and selective CB1 receptor agonist
- GC16826 Arachidonoyl amide CB1 receptor agonist
- GC18097 Arachidonoyl Serinol CB1 receptor agonist
- GC11849 Arachidonyl serotonin Arachidonyl serotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 μM.
- GC35381 Arborine Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure.