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GPCR/G protein

Products for  GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC60593 Arbutamine Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine  Chemical Structure
  3. GC10965 ARC 239 dihydrochloride α2B adrenoceptor antagonist ARC 239 dihydrochloride  Chemical Structure
  4. GC10264 Arecoline hydrobromide muscarinic acetylcholine receptor agonist Arecoline hydrobromide  Chemical Structure
  5. GC42851 Arformoterol (tartrate) Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol. Arformoterol (tartrate)  Chemical Structure
  6. GC30764 Argipressin (Vasopressin) Argipressin (Vasopressin) (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin (Vasopressin)  Chemical Structure
  7. GC10117 Aripiprazole 5-HT receptor partial agonist Aripiprazole  Chemical Structure
  8. GC35386 Aripiprazole D8 Aripiprazole D8  Chemical Structure
  9. GC68687 Aripiprazole-d8

    Aripiprazole-d8 is the deuterated form of Aripiprazole.

    Aripiprazole-d8  Chemical Structure
  10. GC11201 ARM1 LTB4 synthesis inhibitor ARM1  Chemical Structure
  11. GC38887 Arotinolol Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol  Chemical Structure
  12. GC34114 ARS-1323 ARS-1323, the racemate of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1. ARS-1323  Chemical Structure
  13. GC65480 ARS-1323-alkyne ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells. ARS-1323-alkyne  Chemical Structure
  14. GC34055 ARS-1620 ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics. ARS-1620  Chemical Structure
  15. GC34091 ARS-1630 ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1. ARS-1630  Chemical Structure
  16. GC19037 ARS-853 ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 uM. ARS-853  Chemical Structure
  17. GC10205 Arvanil Cannabinoid CB1 and vanilloid TRPV1 (VR1) agonist Arvanil  Chemical Structure
  18. GC12018 AS 1269574 GPR119 receptor agonist AS 1269574  Chemical Structure
  19. GC17525 AS 19 Potent 5-HT7 agonist AS 19  Chemical Structure
  20. GC11467 AS 2034178 AS 2034178, a specific and orally active GPR40 agonist, exhibits glucose-dependent insulin secretion enhancement. AS 2034178  Chemical Structure
  21. GC31774 AS-35 AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities. AS-35  Chemical Structure
  22. GC31904 AS2717638 AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638  Chemical Structure
  23. GC31702 Asapiprant (S-555739) Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM. Asapiprant (S-555739)  Chemical Structure
  24. GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor Asenapine  Chemical Structure
  25. GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Asenapine maleate  Chemical Structure
  26. GC31870 ASP-4058 ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. ASP-4058  Chemical Structure
  27. GC62851 ASP-4058 hydrochloride ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. ASP-4058 hydrochloride  Chemical Structure
  28. GC64341 ASP2453 ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM. ASP2453  Chemical Structure
  29. GC35409 ASP6432 ASP6432 is a potent and selective type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC50s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively. ASP6432  Chemical Structure
  30. GC16216 Asterric Acid ETA receptor inhibitor Asterric Acid  Chemical Structure
  31. GC16218 Astressin corticotropin-releasing factor (CRF) receptor antagonist Astressin  Chemical Structure
  32. GC15720 Astressin 2B

    Astressin 2B is selective and potent antagonist of corticotropin-releasing factor receptor 2 (CRF2) (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively) that antagonizes CRF2-mediated inhibition of gastric emptying.

    Astressin 2B  Chemical Structure
  33. GC16807 AT 1015 Long-acting 5-HT2A antagonist AT 1015  Chemical Structure
  34. GC10994 ATC 0065

    MCH1 antagonist,potent and selective

    ATC 0065  Chemical Structure
  35. GC10700 ATC 0175 hydrochloride ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC 0175 hydrochloride  Chemical Structure
  36. GC14711 ATI-2341 CXCR4 allosteric agonist ATI-2341  Chemical Structure
  37. GC38541 ATI-2341 TFA ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 TFA  Chemical Structure
  38. GC30791 Atipamezole (MPV 1248) Atipamezole (MPV 1248) (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM. Atipamezole (MPV 1248)  Chemical Structure
  39. GC16106 Atipamezole hydrochloride α2-adrenergic receptor antagonist Atipamezole hydrochloride  Chemical Structure
  40. GC12194 Atosiban

    mixed antagonist of oxytocin and vasopressin receptors

    Atosiban  Chemical Structure
  41. GC39849 Atosiban acetate Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban acetate  Chemical Structure
  42. GC46893 Atranorin A depside lichen metabolite with diverse biological activities Atranorin  Chemical Structure
  43. GC35424 Atrasentan Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA. Atrasentan  Chemical Structure
  44. GC11783 Atrasentan hydrochloride Atrasentan hydrochloride  Chemical Structure
  45. GC11314 Atrial natriuretic factor (1-28) (rat) Atrial natriuretic factor (1-28) (rat) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. Atrial natriuretic factor (1-28) (rat)  Chemical Structure
  46. GC34023 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Atrial Natriuretic Peptide (ANP) (1-28), human, porcine  Chemical Structure
  47. GC34025 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate  Chemical Structure
  48. GC35426 Atrial Natriuretic Peptide (ANP) (1-28), rat TFA Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. Atrial Natriuretic Peptide (ANP) (1-28), rat TFA  Chemical Structure
  49. GC16526 Atropine MAChRs antagonist Atropine  Chemical Structure
  50. GC35427 Atropine methyl bromide A muscarinic acetylcholine receptor antagonist Atropine methyl bromide  Chemical Structure
  51. GC35428 Atropine sulfate Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate  Chemical Structure
  52. GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect. Atropine sulfate monohydrate  Chemical Structure
  53. GC65389 Auglurant Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant  Chemical Structure
  54. GC12065 AVE 0991 AVE 0991 is a Nonpeptide Mimic of the Effects of Angiotensin-(1-7) on the Endothelium. AVE 0991  Chemical Structure
  55. GC17686 AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist AVE 0991 sodium salt  Chemical Structure
  56. GC14115 AVE-1625 AVE-1625 (AVE1625) is an orally active CB1 receptor antagonist. AVE-1625  Chemical Structure
  57. GC19032 AVex-73 hydrochloride AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM. AVex-73 hydrochloride  Chemical Structure
  58. GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). AVN-492  Chemical Structure
  59. GC11405 Avosentan Avosentan  Chemical Structure
  60. GC50655 AZ 10397767 AZ 10397767  Chemical Structure
  61. GC46092 AZ 12216052 A positive allosteric modulator of mGluR8 AZ 12216052  Chemical Structure
  62. GC50578 AZ 1729 FFA2 allosteric agonist; displays bias for the Gi signaling pathway AZ 1729  Chemical Structure
  63. GC31456 AZ-1355

    AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.

    AZ-1355  Chemical Structure
  64. GC18152 AZ-3451

    A potent, and selective PAR2 antagonist with Kd of 13.5 nM.

    AZ-3451  Chemical Structure
  65. GC65213 AZ084 AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. AZ084  Chemical Structure
  66. GC60611 AZ12672857 AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM). AZ12672857  Chemical Structure
  67. GC15687 Azasetron HCl Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron HCl  Chemical Structure
  68. GC35446 AZD 2066 AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066  Chemical Structure
  69. GC60614 AZD 2066 hydrate AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate  Chemical Structure
  70. GC31233 AZD 9272 A negative allosteric modulator of mGluR5 receptors AZD 9272  Chemical Structure
  71. GC63284 AZD-4818 AZD-4818 is a potent antagonist of chemokine CCR1. AZD-4818  Chemical Structure
  72. GC32707 AZD-5069 A CXCR2 antagonist AZD-5069  Chemical Structure
  73. GC64274 AZD-5672 AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672  Chemical Structure
  74. GC31097 AZD-8529 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD-8529  Chemical Structure
  75. GC60065 AZD-8529 mesylate AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD-8529 mesylate  Chemical Structure
  76. GC14956 AZD1283 Potent P2Y12 antagonist AZD1283  Chemical Structure
  77. GC62855 AZD1940 AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940  Chemical Structure
  78. GC31643 AZD1979 AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM. AZD1979  Chemical Structure
  79. GC12434 AZD1981 CRTh2 antagonist,potent and selective AZD1981  Chemical Structure
  80. GC31662 AZD2098 A CCR4 receptor antagonist AZD2098  Chemical Structure
  81. GC60615 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423  Chemical Structure
  82. GC32585 AZD2906 AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906  Chemical Structure
  83. GC19049 AZD4635 AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors. AZD4635  Chemical Structure
  84. GC64312 AZD4721 AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721  Chemical Structure
  85. GC64949 AZD5423 AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423  Chemical Structure
  86. GC19051 AZD7594 AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. AZD7594  Chemical Structure
  87. GC31653 AZD8797 AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively. AZD8797  Chemical Structure
  88. GC31894 AZD9567 AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. AZD9567  Chemical Structure
  89. GC13277 Azilsartan Potent angiotensin II type 1 (AT1) receptor inverse agonist Azilsartan  Chemical Structure
  90. GC35452 Azilsartan D5 Azilsartan D5 (TAK-536 D5) is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist. Azilsartan D5  Chemical Structure
  91. GC11407 Azilsartan Medoxomil

    Angiotensin II receptor type 1 antagonist

    Azilsartan Medoxomil  Chemical Structure
  92. GC10642 Azilsartan medoxomil monopotassium

    Angiotensin II receptor type 1 antagonist

    Azilsartan medoxomil monopotassium  Chemical Structure
  93. GC66468 Azilsartan mepixetil Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A). Azilsartan mepixetil  Chemical Structure
  94. GC66440 Azilsartan mopivabil Azilsartan mopivabil is the potent antagonist of angiotensin II receptor. Azilsartan mopivabil  Chemical Structure
  95. GC31430 AZP-531 AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. AZP-531  Chemical Structure
  96. GC14491 B-HT 920 A potent agonist of D2 receptors B-HT 920  Chemical Structure
  97. GC14514 B-HT 933 dihydrochloride Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. B-HT 933 dihydrochloride  Chemical Structure
  98. GC50215 BA 1 Potent bombesin agonist BA 1  Chemical Structure
  99. GC60619 BA 1 TFA BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors. BA 1 TFA  Chemical Structure
  100. GC17201 BAF312 (Siponimod) BAF312 (Siponimod) (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator. BAF312 (Siponimod)  Chemical Structure
  101. GC25120 Balixafortide (POL6326) Balixafortide (POL6326)  Chemical Structure

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