GPCR/G protein
- Neuropeptide FF/AF Receptors(43)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(415)
- Acetylcholine(19)
- Adenosine Deaminase(12)
- Adenosine Receptor(133)
- Adenosine Kinase(5)
- Adiponectin Receptor(4)
- Adrenergic Receptor(404)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(110)
- Bombesin Receptors(22)
- Bradykinin Receptors(27)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(137)
- Calcimimetic Agent(3)
- CaSR(24)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(79)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(82)
- CysLT1 receptor(1)
- Endothelin Receptor(50)
- EP1 Receptor(3)
- EP4 Receptor(5)
- ERRγ(2)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(20)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(22)
- GIP Receptor(5)
- Glucagon Receptor(66)
- Glucocorticoid Receptor(87)
- GLUT1(2)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(13)
- GPR109A(4)
- GPR119(11)
- GPR120(12)
- GPR35(8)
- GPR44(1)
- GPR55(10)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(55)
- LPA Receptor(15)
- LPL Receptor(60)
- LTD4 Receptor(2)
- mGluR (115)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(49)
- Melatonin Receptors(23)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(21)
- NK2 Receptors(7)
- NK3 Receptor(8)
- NOP Receptor(22)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(42)
- Oxytocin Receptors(21)
- P2Y Receptor(55)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(15)
- PGD2 Receptor(2)
- Prostaglandin Receptor(168)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(4)
- S1P receptor(9)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(34)
- Sigma Receptor(54)
- Vasopressin Receptor(33)
- 17,20-lyase(7)
- Ras(118)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(5)
- TSH Receptor(10)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(22)
- GPR84(5)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(4)
- CRFR(21)
- RGS Protein(7)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(23)
- GPR139(3)
- mAChR(179)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(72)
- cGMP(18)
- GRK(1)
Products for GPCR/G protein
- Cat.No. Product Name Information
- GC60593 Arbutamine Arbutamine is a short-acting, potent and nonselective β-adrenoceptor agonist.
- GC10965 ARC 239 dihydrochloride α2B adrenoceptor antagonist
- GC10264 Arecoline hydrobromide muscarinic acetylcholine receptor agonist
- GC42851 Arformoterol (tartrate) Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol.
- GC30764 Argipressin (Vasopressin) Argipressin (Vasopressin) (Arg8-vasopressin) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
- GC10117 Aripiprazole 5-HT receptor partial agonist
- GC35386 Aripiprazole D8
-
GC68687
Aripiprazole-d8
Aripiprazole-d8 is the deuterated form of Aripiprazole.
- GC11201 ARM1 LTB4 synthesis inhibitor
- GC38887 Arotinolol Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker.
- GC34114 ARS-1323 ARS-1323, the racemate of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
- GC65480 ARS-1323-alkyne ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
- GC34055 ARS-1620 ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
- GC34091 ARS-1630 ARS-1630, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.
- GC19037 ARS-853 ARS-853 is a selective, covalent KRASG12C inhibitor with an IC50 of 2.5 uM.
- GC10205 Arvanil Cannabinoid CB1 and vanilloid TRPV1 (VR1) agonist
- GC12018 AS 1269574 GPR119 receptor agonist
- GC17525 AS 19 Potent 5-HT7 agonist
- GC11467 AS 2034178 AS 2034178, a specific and orally active GPR40 agonist, exhibits glucose-dependent insulin secretion enhancement.
- GC31774 AS-35 AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.
- GC31904 AS2717638 AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5.
- GC31702 Asapiprant (S-555739) Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
- GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor
- GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.
- GC31870 ASP-4058 ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
- GC62851 ASP-4058 hydrochloride ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
- GC64341 ASP2453 ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
- GC35409 ASP6432 ASP6432 is a potent and selective type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC50s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively.
- GC16216 Asterric Acid ETA receptor inhibitor
- GC16218 Astressin corticotropin-releasing factor (CRF) receptor antagonist
-
GC15720
Astressin 2B
Astressin 2B is selective and potent antagonist of corticotropin-releasing factor receptor 2 (CRF2) (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively) that antagonizes CRF2-mediated inhibition of gastric emptying.
- GC16807 AT 1015 Long-acting 5-HT2A antagonist
-
GC10994
ATC 0065
MCH1 antagonist,potent and selective
- GC10700 ATC 0175 hydrochloride ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively.
- GC14711 ATI-2341 CXCR4 allosteric agonist
- GC38541 ATI-2341 TFA ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13.
- GC30791 Atipamezole (MPV 1248) Atipamezole (MPV 1248) (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.
- GC16106 Atipamezole hydrochloride α2-adrenergic receptor antagonist
-
GC12194
Atosiban
mixed antagonist of oxytocin and vasopressin receptors
- GC39849 Atosiban acetate Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue.
- GC46893 Atranorin A depside lichen metabolite with diverse biological activities
- GC35424 Atrasentan Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA.
- GC11783 Atrasentan hydrochloride
- GC11314 Atrial natriuretic factor (1-28) (rat) Atrial natriuretic factor (1-28) (rat) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
- GC34023 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch.
- GC34025 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch.
- GC35426 Atrial Natriuretic Peptide (ANP) (1-28), rat TFA Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.
- GC16526 Atropine MAChRs antagonist
- GC35427 Atropine methyl bromide A muscarinic acetylcholine receptor antagonist
- GC35428 Atropine sulfate Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively.
- GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
- GC65389 Auglurant Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human).
- GC12065 AVE 0991 AVE 0991 is a Nonpeptide Mimic of the Effects of Angiotensin-(1-7) on the Endothelium.
- GC17686 AVE 0991 sodium salt Ang-(1-7) receptor Mas agonist
- GC14115 AVE-1625 AVE-1625 (AVE1625) is an orally active CB1 receptor antagonist.
- GC19032 AVex-73 hydrochloride AVex-73 hydrochloride is a Sigma-1 Receptor agonist with an IC50 of 860 nM.
- GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM).
- GC11405 Avosentan
- GC50655 AZ 10397767
- GC46092 AZ 12216052 A positive allosteric modulator of mGluR8
- GC50578 AZ 1729 FFA2 allosteric agonist; displays bias for the Gi signaling pathway
-
GC31456
AZ-1355
AZ-1355 is an effctive lipid-lowering compound, which also inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.
-
GC18152
AZ-3451
A potent, and selective PAR2 antagonist with Kd of 13.5 nM.
- GC65213 AZ084 AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM.
- GC60611 AZ12672857 AZ12672857 is an orally active inhibitor of EphB4 (IC50=1.3 nM) and Src kinases. AZ12672857 shows good inhibition of proliferation of c-Src transfected 3T3 cells (IC50=2 nM) as well as autophosphorylation of EphB4 in transfected CHO-K1 cells (IC50=9 nM).
- GC15687 Azasetron HCl Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist.
- GC35446 AZD 2066 AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5.
- GC60614 AZD 2066 hydrate AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5.
- GC31233 AZD 9272 A negative allosteric modulator of mGluR5 receptors
- GC63284 AZD-4818 AZD-4818 is a potent antagonist of chemokine CCR1.
- GC32707 AZD-5069 A CXCR2 antagonist
- GC64274 AZD-5672 AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM).
- GC31097 AZD-8529 AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
- GC60065 AZD-8529 mesylate AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
- GC14956 AZD1283 Potent P2Y12 antagonist
- GC62855 AZD1940 AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively.
- GC31643 AZD1979 AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM.
- GC12434 AZD1981 CRTh2 antagonist,potent and selective
- GC31662 AZD2098 A CCR4 receptor antagonist
- GC60615 AZD2423 AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator.
- GC32585 AZD2906 AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats.
- GC19049 AZD4635 AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors.
- GC64312 AZD4721 AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2).
- GC64949 AZD5423 AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM).
- GC19051 AZD7594 AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM.
- GC31653 AZD8797 AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively.
- GC31894 AZD9567 AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM.
- GC13277 Azilsartan Potent angiotensin II type 1 (AT1) receptor inverse agonist
- GC35452 Azilsartan D5 Azilsartan D5 (TAK-536 D5) is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
-
GC11407
Azilsartan Medoxomil
Angiotensin II receptor type 1 antagonist
-
GC10642
Azilsartan medoxomil monopotassium
Angiotensin II receptor type 1 antagonist
- GC66468 Azilsartan mepixetil Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).
- GC66440 Azilsartan mopivabil Azilsartan mopivabil is the potent antagonist of angiotensin II receptor.
- GC31430 AZP-531 AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
- GC14491 B-HT 920 A potent agonist of D2 receptors
- GC14514 B-HT 933 dihydrochloride Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively.
- GC50215 BA 1 Potent bombesin agonist
- GC60619 BA 1 TFA BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors.
- GC17201 BAF312 (Siponimod) BAF312 (Siponimod) (BAF-312) is an orally active and selective sphingosine-1-phosphate (S1P) receptor modulator.
- GC25120 Balixafortide (POL6326)