Bombesin Receptors
Bombesin, a peptide of 14 amino acids, is an amphibian homolog to the mammalian gastrin-releasing peptide (GRP), that has been extensively studied as a targeting ligand for diagnosis and therapy of GRP positive tumors, such as breast, pancreas, lungs and prostate cancers. Bombesin binds to and activates G-protein coupled receptors, known as gastrin releasing peptide receptor (GRPR).
Bombesin, a tetradecapeptide isolated from the skin of the frog Bombina bombina, have shown broad spectrum of biological activities. The BBS activates three G protein-coupled receptors: bombesin receptor 1 (BB1), bombesin receptor 2 (BB2), and bombesin receptor 3 (BB3). BBS-like peptides-Neuromedin B (NB) and gastrin releasing peptide (GRP) are natural ligand of the BB1 and BB2 receptors, respectively.
In mammals, BBS receptors and BBS-like peptides are distributed in the Central Nervous System (CNS) including regions involved in the cardiorespiratory control.
The mammalian bombesin G-protein-coupled receptor subfamily comprises three structurally related members, the receptors for neuromedin B (NMBR or BB1), gastrin-releasing peptide (GRPR or BB2), and bombesin receptor subtype-3 (BRS-3 or BB3).
Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor implicated in the regulation of energy homeostasis.
Products for Bombesin Receptors
- Cat.No. Product Name Information
- GC14908 Alytesin Amphibian bombesin-like peptide
- GC50215 BA 1 Potent bombesin agonist
- GC60619 BA 1 TFA BA 1 TFA is a potent agonist for the bombesin (BB) family of receptors.
- GC15165 BIM 187 Bombesin/GRP receptor agonist
- GC14279 BIM 189 Bombesin antagonist
- GC17080 BIM 23042 Antagonist of neuromedin B receptor,selective
- GC11620 BIM 23127 Antagonist of neuromedin B receptor
- GC14014 Bombesin Neuropeptide with many biological effects
- GC16415 GRP (human) GRP (human) (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release.
- GC16854 GRP (porcine) agonist for the gastrin-releasing peptide receptor (GRPR)
- GC36404 Kuwanon G Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity.
- GC38510 Kuwanon H eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex).
- GC14662 Litorin Amphibian bombesin-like peptide
- GC19413 MK-5046 MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).
- GC33152 ML-18 A BB3 receptor antagonist
- GC12707 Neuromedin B (porcine) Neuromedin B (porcine) (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
- GC16376 Neuromedin C (porcine) Mammalian bombesin-like neuropeptide
- GC13768 PD 176252 gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist
- GC37072 RC-3095 RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist.
- GC64112 RC-3095 TFA RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist.
- GC17156 [D-Phe12,Leu14]-Bombesin Bombesin receptor antagonist
- GC15163 [D-Phe12]-Bombesin Bombesin receptor antagonist