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Home >> Signaling Pathways >> GPCR/G protein >> Bradykinin Receptors

Bradykinin Receptors

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.

Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.

Products for  Bradykinin Receptors

  1. Cat.No. Product Name Information
  2. GA20221 (Hyp³)-Bradykinin (Hyp³)-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. (Hyp³)-Bradykinin Chemical Structure
  3. GC16761 Bombinakinin M Potent bradykinin receptor agonist Bombinakinin M Chemical Structure
  4. GC14629 Bombinakinin-GAP Bioactive bradykinin-related peptide Bombinakinin-GAP Chemical Structure
  5. GC35548 Bradykinin Bradykinin is an active peptide that is generated by the kallikrein-kinin system. Bradykinin Chemical Structure
  6. GC32576 Bradykinin 1-3 Bradykinin 1-3 is a 3-amino acid residue peptide. Bradykinin 1-3 Chemical Structure
  7. GC32592 Bradykinin 1-5 Bradykinin 1-5 is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). Bradykinin 1-5 Chemical Structure
  8. GC32605 Bradykinin 1-6 Bradykinin 1-6 is an amino-truncated Bradykinin peptide. Bradykinin 1-6 Chemical Structure
  9. GC32601 Bradykinin 1-7(Bradykinin Fragment 1-​7) Bradykinin 1-7 (Bradykinin Fragment 1-​7) is an amino-truncated Bradykinin peptide. Bradykinin 1-7(Bradykinin Fragment 1-​7) Chemical Structure
  10. GC34042 Bradykinin 2-9 (Des-Arg1-bradykinin) Bradykinin 2-9 (Des-Arg1-bradykinin) is an amino-truncated Bradykinin peptide. Bradykinin 2-9 (Des-Arg1-bradykinin) Chemical Structure
  11. GC16820 ELN441958

    Potent and selective bradykinin B1 receptor antagonist

     ELN441958 Chemical Structure
  12. GC31926 FR167344 free base FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base Chemical Structure
  13. GC15587 HOE 140 HOE 140 (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. HOE 140 Chemical Structure
  14. GC43888 Icatibant (acetate) Icatibant is a synthetic peptide antagonist of the bradykinin B2 receptor with IC50 and Ki values of 1.07 and 0.798 nM, respectively, in guinea pig ileal cell membranes. Icatibant (acetate) Chemical Structure
  15. GC17164 Lys-Bradykinin Endogenous bradykinin receptor agonist Lys-Bradykinin Chemical Structure
  16. GC10255 Lys-[Des-Arg9]Bradykinin bradykinin B1 receptor agonist Lys-[Des-Arg9]Bradykinin Chemical Structure
  17. GC61535 Lys-[Des-Arg9]Bradykinin TFA Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA Chemical Structure
  18. GC15188 MEN 11270 B2 bradykinin receptor antagonist MEN 11270 Chemical Structure
  19. GC16110 R 715 bradykinin B1 receptor antagonist R 715 Chemical Structure
  20. GC13179 R 892 bradykinin B1 receptor antagonist R 892 Chemical Structure
  21. GC50373 Retrobradykinin Reverse analog of Bradykinin Retrobradykinin Chemical Structure
  22. GC11961 Sar-[D-Phe8]-des-Arg9-Bradykinin selective bradykinin B1 receptor agonist Sar-[D-Phe8]-des-Arg9-Bradykinin Chemical Structure
  23. GC19339 SSR240612 SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively. SSR240612 Chemical Structure
  24. GC17933 WIN 64338 hydrochloride bradykinin B2 receptor antagonist, competitive WIN 64338 hydrochloride Chemical Structure
  25. GC35015 [Des-Arg9]-Bradykinin [Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors. [Des-Arg9]-Bradykinin Chemical Structure
  26. GC33850 [Des-Arg9]-Bradykinin acetate [Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors. [Des-Arg9]-Bradykinin acetate Chemical Structure
  27. GC18038 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin Selective bradykinin B2 receptor agonist [Phe8Ψ(CH-NH)-Arg9]-Bradykinin Chemical Structure

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