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Home >> Signaling Pathways >> GPCR/G protein >> Endothelin Receptor

Endothelin Receptor

Endothelin receptors are members of rhodopsin-like g-protein coupled receptor (GPCRA) with 4 types (ETA, ETB1, ETB2 and ETC), which mediate various physiological processes including vasoconstriction, vasodilation, and neurotransmission etc.

Products for  Endothelin Receptor

  1. Cat.No. Product Name Information
  2. GC50247 A 127722 Highly potent, selective ETA antagonist; orally bioavailable A 127722 Chemical Structure
  3. GC60544 A-192621 A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 Chemical Structure
  4. GC13236 ACT-132577 ACT-132577 (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. ACT-132577 Chemical Structure
  5. GC17184 Ambrisentan ETA-receptor antagonist Ambrisentan Chemical Structure
  6. GC32548 Aminaftone (Aminaftone) Aminaftone (Aminaftone), a derivative of 4-aminobenzoic acid, downregulates endothelin-1 (ET-1) production in vitro by interfering with the transcription of the pre-pro-ET-1 gene. Aminaftone (Aminaftone) Chemical Structure
  7. GC68320 Aprocitentan D4 Aprocitentan D4 Chemical Structure
  8. GC35424 Atrasentan Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA. Atrasentan Chemical Structure
  9. GC11783 Atrasentan hydrochloride Atrasentan hydrochloride Chemical Structure
  10. GC11314 Atrial natriuretic factor (1-28) (rat) Atrial natriuretic factor (1-28) (rat) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. Atrial natriuretic factor (1-28) (rat) Chemical Structure
  11. GC34023 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Chemical Structure
  12. GC34025 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Chemical Structure
  13. GC35426 Atrial Natriuretic Peptide (ANP) (1-28), rat TFA Atrial Natriuretic Peptide (ANP) (1-28), rat (TFA) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner. Atrial Natriuretic Peptide (ANP) (1-28), rat TFA Chemical Structure
  14. GC11405 Avosentan Avosentan Chemical Structure
  15. GC16269 Bosentan Endothelin receptor antagonist Bosentan Chemical Structure
  16. GC11465 Bosentan Hydrate endothelin receptor antagonist Bosentan Hydrate Chemical Structure
  17. GC15887 BQ-123 Selective ETA receptor antagonist BQ-123 Chemical Structure
  18. GC60094 BQ-3020 TFA BQ-3020 (TFA) is a selective agonist of ETB receptor, inhibits [125I]ET-1 binding to ETB receptor with an IC50 of 0.2 nM in cerebellum, and causes vasoconstriction. BQ-3020 TFA Chemical Structure
  19. GC35546 BQ-788 BQ-788 is a potent, selective ETB receptor antagonist with IC50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC50 of 1300 nM. BQ-788 Chemical Structure
  20. GC15916 BQ-788 sodium salt ET B-receptor antagonist,potent and selective BQ-788 sodium salt Chemical Structure
  21. GC68435 Clazosentan Clazosentan Chemical Structure
  22. GC35811 Darusentan Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan Chemical Structure
  23. GC64457 Endothelin 1 (swine, human) (TFA) Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 (swine, human) (TFA) Chemical Structure
  24. GC30485 Endothelin 1 swine, human Endothelin 1 swine, human is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 swine, human Chemical Structure
  25. GC13924 Endothelin 3 (human, rat) Endothelin 3 (human, rat) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB. Endothelin 3 (human, rat) Chemical Structure
  26. GC30577 Endothelin Mordulator 1 Endothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders. Endothelin Mordulator 1 Chemical Structure
  27. GC30937 IRL-1620 IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. IRL-1620 Chemical Structure
  28. GC38641 IRL-1620 TFA IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. IRL-1620 TFA Chemical Structure
  29. GC15246 IRL-2500 endothelin receptor antagonist IRL-2500 Chemical Structure
  30. GC18501 Kendomycin Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM). Kendomycin Chemical Structure
  31. GC17785 Macitentan Endothelin (ET)(A) and ET(B) receptor antagonist Macitentan Chemical Structure
  32. GC36525 Macitentan n-butyl analogue Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan n-butyl analogue Chemical Structure
  33. GC45723 Macitentan-d4 An internal standard for the quantification of macitentan Macitentan-d4 Chemical Structure
  34. GC60266 Nebentan free base Nebentan free base (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan free base Chemical Structure
  35. GC61118 Nebentan potassium Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan potassium Chemical Structure
  36. GC34031 PD-159020 PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively. PD-159020 Chemical Structure
  37. GC32528 Ro 46-2005 Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. Ro 46-2005 Chemical Structure
  38. GC63837 Ro 46-8443 Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 Chemical Structure
  39. GC13175 Sarafotoxin S6a Endothelin receptor agonist Sarafotoxin S6a Chemical Structure
  40. GC14678 Sarafotoxin S6b non-selective endothelin receptor agonist Sarafotoxin S6b Chemical Structure
  41. GC17769 Sitaxentan sodium Sitaxentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors. Sitaxentan sodium Chemical Structure
  42. GC37644 Sitaxsentan Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist. Sitaxsentan Chemical Structure
  43. GC32479 Sparsentan (RE-021) Sparsentan (RE-021) (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. Sparsentan (RE-021) Chemical Structure
  44. GC12231 Sulfisoxazole selective ETA endothelin receptor antagonist Sulfisoxazole Chemical Structure
  45. GC30942 Tezosentan (RO 610612) Tezosentan (RO 610612) (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively. Tezosentan (RO 610612) Chemical Structure
  46. GC32556 ZD-1611 ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke. ZD-1611 Chemical Structure
  47. GC16862 Zibotentan (ZD4054) Zibotentan (ZD4054) (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan (ZD4054) Chemical Structure

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