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Home >> Signaling Pathways >> GPCR/G protein >> 5-HT Receptor

5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC14392 SB 242084 5-HT2C receptor antagonist SB 242084 Chemical Structure
  3. GC15138 SB 243213 dihydrochloride SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride Chemical Structure
  4. GC38173 SB 243213 hydrochloride SB 243213 hydrochloride Chemical Structure
  5. GC12383 SB 258585 hydrochloride 5-HT6 receptor antagonist SB 258585 hydrochloride Chemical Structure
  6. GC37596 SB 258719 SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 Chemical Structure
  7. GC12798 SB 258719 hydrochloride Selective 5-HT7 receptor antagonist SB 258719 hydrochloride Chemical Structure
  8. GC37597 SB 271046 Hydrochloride SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride Chemical Structure
  9. GC15660 SB 399885 hydrochloride 5-HT6 antagonist SB 399885 hydrochloride Chemical Structure
  10. GC12524 SB 699551 5-ht5a receptor antagonist SB 699551 Chemical Structure
  11. GC44875 SB-242084 (hydrochloride) SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB-242084 (hydrochloride) Chemical Structure
  12. GC37599 SB-269970 SB-269970 is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 Chemical Structure
  13. GC31025 SB-616234A SB-616234A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity. SB-616234A Chemical Structure
  14. GC38492 SB228357 SB228357 Chemical Structure
  15. GC10769 SB269970 HCl SB269970 HCl is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB269970 HCl Chemical Structure
  16. GC14550 SB271046 5-HT6 receptor antagonist, orally active SB271046 Chemical Structure
  17. GC12091 SB742457 SB742457 (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors. SB742457 Chemical Structure
  18. GC17219 SDZ 205-557 hydrochloride 5-HT3/5-HT4 receptor antagonist SDZ 205-557 hydrochloride Chemical Structure
  19. GC12735 SDZ SER 082 fumarate 5-HT2B/2C receptor antagonist SDZ SER 082 fumarate Chemical Structure
  20. GC14843 Serotonin HCl Endogenous 5-HT receptor agonist Serotonin HCl Chemical Structure
  21. GC69879 Serotonin-d4

    Serotonin-d4 is a deuterated derivative of serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also an inhibitor of catechol-O-methyltransferase (COMT), with a Ki value of 44 μM.

     Serotonin-d4 Chemical Structure
  22. GC30787 Sertindole (Lu 23-174) Sertindole (Lu 23-174) (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole (Lu 23-174) Chemical Structure
  23. GC10991 SGS 518 oxalate 5-HT6 antagonist SGS 518 oxalate Chemical Structure
  24. GC11416 Spiperone hydrochloride 5-HT2A serotonin and selective D2-like dopamine receptor antagonist Spiperone hydrochloride Chemical Structure
  25. GC15630 SR 57227 hydrochloride

    A 5-HT3 receptor agonist

     SR 57227 hydrochloride Chemical Structure
  26. GC16910 ST 1936 oxalate ST 1936 oxalate is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST 1936 oxalate Chemical Structure
  27. GC34033 Sulamserod (RS-100302) Sulamserod (RS-100302) is a 5-HT4 receptor antagonist, with antiarrhythmic activities. Sulamserod (RS-100302) Chemical Structure
  28. GC31044 T 82 T 82 is a potent 5-HT3 antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease. T 82 Chemical Structure
  29. GC10945 Tandospirone Anxiolytic and antidepressant reagent Tandospirone Chemical Structure
  30. GC37734 Tandospirone citrate Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). Tandospirone citrate Chemical Structure
  31. GC11490 TCB-2 5-HT2A receptor agonist TCB-2 Chemical Structure
  32. GC30273 Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) Chemical Structure
  33. GC17826 Tegaserod maleate Partial agonist of 5-HT4 Tegaserod maleate Chemical Structure
  34. GC30826 Temanogrel (APD791) Temanogrel (APD791) is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM. Temanogrel (APD791) Chemical Structure
  35. GC32637 Tertatolol ((±)-Tertatolol) Tertatolol ((±)-Tertatolol) is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects. Tertatolol ((±)-Tertatolol) Chemical Structure
  36. GC19354 TG6-10-1 TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors. TG6-10-1 Chemical Structure
  37. GC11977 Thioridazine HCl Thioridazine HCl, an orally active antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine HCl Chemical Structure
  38. GC10121 Tianeptine sodium Tianeptine sodium is a selective facilitator of 5-HT uptake. Tianeptine sodium Chemical Structure
  39. GC26002 Trazodone Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders. Trazodone Chemical Structure
  40. GC14927 Trazodone HCl Trazodone (hydrochloride) (AF-1161) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders. Trazodone HCl Chemical Structure
  41. GC17488 Trimipramine (maleate) potent antagonist of histamine H1 receptor Trimipramine (maleate) Chemical Structure
  42. GC16284 Tropisetron 5-HT3 receptor antagonist Tropisetron Chemical Structure
  43. GC15223 Tropisetron Hydrochloride 5-HT3 receptor antagonist Tropisetron Hydrochloride Chemical Structure
  44. GC65265 UNC9994 hydrochloride UNC9994 hydrochloride is a functionally selective, β-arrestin–biased dopamine D2 receptor (D2R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride Chemical Structure
  45. GC37861 Urapidil Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. Urapidil Chemical Structure
  46. GC15829 Urapidil HCl Urapidil HCl is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil HCl Chemical Structure
  47. GC64080 Usmarapride Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride Chemical Structure
  48. GC64660 Usmarapride free base Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride free base Chemical Structure
  49. GC30964 Vabicaserin hydrochloride (SCA 136) Vabicaserin hydrochloride (SCA 136) is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM. Vabicaserin hydrochloride (SCA 136) Chemical Structure
  50. GC10911 Venlafaxine hydrochloride Dual serotonin/noradrenalin re-uptake inhibitor Venlafaxine hydrochloride Chemical Structure
  51. GC37906 Vilazodone D8 Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. Vilazodone D8 Chemical Structure
  52. GC14437 Vortioxetine (Lu AA21004) HBr Vortioxetine (Lu AA21004) HBr is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine (Lu AA21004) HBr Chemical Structure
  53. GC13501 VUF 10166 5-HT3 receptor antagonist VUF 10166 Chemical Structure
  54. GC11980 WAY 161503 hydrochloride 5-HT2C receptor agonist WAY 161503 hydrochloride Chemical Structure
  55. GC33344 WAY 163909 WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with a Ki of 10.5±1.1 nM. WAY 163909 Chemical Structure
  56. GC14149 WAY 208466 dihydrochloride 5-HT6 agonist WAY 208466 dihydrochloride Chemical Structure
  57. GC12300 WAY 629 hydrochloride

    5-HT2C agonist

     WAY 629 hydrochloride Chemical Structure
  58. GC15754 WAY-100635 Maleate 5-HT1A receptor agonist WAY-100635 Maleate Chemical Structure
  59. GC45157 WAY-161503 WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. WAY-161503 Chemical Structure
  60. GC31041 Wf-516 Wf-516 is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively, and has potent antidepressant activity. Wf-516 Chemical Structure
  61. GC19389 YL0919 YL0919 (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT1Areceptor agonist (Ki=0.19 nM). YL0919 Chemical Structure
  62. GC31503 YM348 YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM). YM348 Chemical Structure
  63. GC17343 Zacopride hydrochloride 5-HT3 receptor antagonist and 5-HT4 receptor agonist Zacopride hydrochloride Chemical Structure
  64. GC31203 Zatosetron maleate (LY 277359 maleate) Zatosetron maleate (LY 277359 maleate) is a potent and selective 5HT3 receptor antagonist. Zatosetron maleate (LY 277359 maleate) Chemical Structure
  65. GC37969 Ziprasidone D8 Ziprasidone D8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. Ziprasidone D8 Chemical Structure
  66. GC11521 Ziprasidone HCl Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone HCl Chemical Structure
  67. GC17808 Zolmitriptan Potent 5-HT1B/1D/1F agonist Zolmitriptan Chemical Structure
  68. GC14088 Zotepine 5-HT2A receptor and dopamine D2 receptor antagonist Zotepine Chemical Structure

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