GPR109A

GPR109A (also known as hydroxycarboxylic acid receptor 2) is a nicotinic acid/niacin and (D)-beta-hydroxybutyrate receptor. It conveys acid-induced apoptosis in matureneutrophils and may lead to neutrophilapoptosis after niacin activation.

Products for GPR109A

Cat.No. Product Name Information
GC32464 MK-0354 MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
GC15006 MK-6892
GC15653 PF-05212384 (PKI-587) PF-05212384 (PKI-587) (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PF-05212384 (PKI-587) is equally effective in both complexes of mTOR, mTORC1 and mTORC2.