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Home >> Signaling Pathways >> GPCR/G protein >> GPR84

GPR84

GPR84 is a G protein-coupled receptor for medium-chain fatty acids. GPR84 is a receptor for free fatty acids and can be potently activated by saturated medium-chain free fatty acids (MCFAs) like decanoic acid, undecanoic acid and lauric acid. GPR84, a receptor for medium-length free fatty acids is upregulated on protein level in LPS activated tolerant CD14+ monocytes and THP-1 cells.

GPR84 is activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. GPR84 is now considered to be a member of FFA-sensing GPCRs. MCFAs with carbon chain lengths of 9–14 activate GPR84, coupling primarily to a pertussis toxin (PTX)-sensitive Gi/o pathway. GPR84 should be a proinflammatory receptor and may be a novel, attractive target for treating chronic low grade inflammation associated-diseases.

Products for  GPR84

  1. Cat.No. Product Name Information
  2. GC11350 6-OAU

    GTPL5846

     synthetic agonist for GPR84 6-OAU Chemical Structure
  3. GC64229 GPR84 antagonist 1 GPR84 antagonist 1 is a high affinity and highly selective competitive antagonist of human GPR84. GPR84 antagonist 1 Chemical Structure
  4. GC69187 GPR84 antagonist 2

    GPR84 antagonist 2 (compound 33) is an orally effective, selective GPR84 antagonist (IC50=8.95 nM). It has demonstrated greater potency in calcium mobilization assays and inhibits the chemotaxis of neutrophils and macrophages upon activation of GPR84. GPR84 antagonist 2 has potential for research into ulcerative colitis.

     GPR84 antagonist 2 Chemical Structure
  5. GC73332 GPR84 antagonist 3 GPR84 antagonist 3 (compound 42) is a potent GPR84 (G-protein-coupled receptor 84) antagonist. GPR84 antagonist 3 Chemical Structure
  6. GC31712 GPR84 antagonist 8 GPR84 antagonist 8 is a selective GPR84 antagonist. GPR84 antagonist 8 Chemical Structure
  7. GC71478 OX04528 OX04528 (compound 68) is a potent, G-protein biased, and orally active GPR84 agonist. OX04528 Chemical Structure
  8. GC31698 PBI-4050 sodium salt (Setogepram (sodium salt))

    Setogepram sodium; PBI-4050 sodium

     Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. PBI-4050 sodium salt (Setogepram (sodium salt)) Chemical Structure
  9. GC71501 TUG-2208 TUG-2208 (compound 42a) is a GPR84 agonist (pEC50=8.98) with low lipophilicity and good solubility, in vitro permeability and microsomal stability. TUG-2208 Chemical Structure

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