MCHR1 (GPR24)

MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, belongs to a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone, and is one of the melanin-concentrating hormone receptors found in all mammals. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. MCHR1 is thought to regulate appetite, and also functions in stress, anxiety and depression.

Targets for MCHR1 (GPR24)

Products for MCHR1 (GPR24)

Cat.No. Product Name Information
GC31388 ALB-127158(a) ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist.
GC31643 AZD1979 AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM.
GC31479 BMS-819881 BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM.
GC63822 Ethyl linolenate

ALAEE, Ethyl αLinolenate, Ethyl Linolenate, LAEE, Linolenic Acid ethyl ester
Ethyl linolenate is a fatty acid ethyl ester (FAEE).
GC10175 GW 803430

GW 3430
melanin-concentrating hormone receptor 1 (MCH1) antagonist
GC31422 MCH-1 antagonist 1
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM.
GC31628 MCHr1 antagonist 1 MCHR1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a Kb of 1 nM and a Ki of 4 nM at human MCH1, and may be used to reduce the body mass.
GC31505 MCHr1 antagonist 2 MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.
GC31149 Melanin Concentrating Hormone, salmon (MCH (salmon)) Melanin Concentrating Hormone, salmon (MCH (salmon)) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system.
GC36580 Melanin Concentrating Hormone, salmon (TFA)

MCH (salmon) (TFA)
GC36727 Neuropeptide EI, rat Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.
GC31504 NGD-4715 NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist .
GC31506 SB-568849 SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7.
GC17846 SNAP 94847 hydrochloride SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity overMCHα1Aand MCHD2receptors respectively.
GC10865 TC-MCH 7c melanin-concentrating hormone receptor 1 (MCH1R) antagonist
GC40787 γ-Linolenic Acid ethyl ester

GLA ethyl ester
α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables.