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MCHR1 (GPR24)

MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, belongs to a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone, and is one of the melanin-concentrating hormone receptors found in all mammals. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. MCHR1 is thought to regulate appetite, and also functions in stress, anxiety and depression.

Targets for  MCHR1 (GPR24)

Products for  MCHR1 (GPR24)

  1. Cat.No. Product Name Information
  2. GC31388 ALB-127158(a) ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist. ALB-127158(a)  Chemical Structure
  3. GC31643 AZD1979 AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM. AZD1979  Chemical Structure
  4. GC31479 BMS-819881 BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881  Chemical Structure
  5. GC63822 Ethyl linolenate Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate  Chemical Structure
  6. GC10175 GW 803430 melanin-concentrating hormone receptor 1 (MCH1) antagonist GW 803430  Chemical Structure
  7. GC31422 MCH-1 antagonist 1

    MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM.

    MCH-1 antagonist 1  Chemical Structure
  8. GC31628 MCHr1 antagonist 1 MCHR1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a Kb of 1 nM and a Ki of 4 nM at human MCH1, and may be used to reduce the body mass. MCHr1 antagonist 1  Chemical Structure
  9. GC31505 MCHr1 antagonist 2 MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHr1 antagonist 2  Chemical Structure
  10. GC31149 Melanin Concentrating Hormone, salmon (MCH (salmon)) Melanin Concentrating Hormone, salmon (MCH (salmon)) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin Concentrating Hormone, salmon (MCH (salmon))  Chemical Structure
  11. GC36580 Melanin Concentrating Hormone, salmon (TFA) Melanin Concentrating Hormone, salmon (TFA)  Chemical Structure
  12. GC36727 Neuropeptide EI, rat Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms. Neuropeptide EI, rat  Chemical Structure
  13. GC31504 NGD-4715 NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist . NGD-4715  Chemical Structure
  14. GC31506 SB-568849 SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7. SB-568849  Chemical Structure
  15. GC17846 SNAP 94847 hydrochloride SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity overMCHα1Aand MCHD2receptors respectively. SNAP 94847 hydrochloride  Chemical Structure
  16. GC10865 TC-MCH 7c melanin-concentrating hormone receptor 1 (MCH1R) antagonist TC-MCH 7c  Chemical Structure
  17. GC40787 γ-Linolenic Acid ethyl ester α-Linolenic acid (ALA) is an essential fatty acid found in leafy green vegetables. γ-Linolenic Acid ethyl ester  Chemical Structure

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