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Home >> Signaling Pathways >> GPCR/G protein >> Melanocortin (MC) Receptors

Melanocortin (MC) Receptors

Melanocortin receptors (MCRs) comprise a family of five, class A, G protein-coupled receptors designated MC1R-MC5R with diverse physiological roles. MCRs are found in chordates and are regarded as having evolved from a single ancestral receptor, possibly corresponding most closely to MC4R. Signaling by MCRs has primarily been observed as occurring through the stimulatory α unit Gs which activates adenylyl cyclase to produce cAMP.

The central nervous melanocortin system is involved in energy homeostasis, regulating food intake and energy expenditure. The brain melanocortin system is defined as the primary neurons that express neuropeptide ligands, and secondary neurons expressing the predominant neural melanocortin receptors (MC3R, MC4R). Mutations in the gene encoding melanocortin receptor agonists, or the genes encoding MC3R or MC4R cause obesity. The other members of the melanocortin receptor family are primarily expressed in the periphery, and are involved in regulating pigmentation (MC1R), adrenal gland function (MC2R), immune function (MC1R/MC3R), and sebaceous gland activity (MC5R).

Products for  Melanocortin (MC) Receptors

  1. Cat.No. Product Name Information
  2. GC38007 β-Melanocyte Stimulating Hormone (MSH), human TFA β-Melanocyte Stimulating Hormone (MSH), human TFA Chemical Structure
  3. GC61462 γ-1-Melanocyte Stimulating Hormone (MSH), amide γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure
  4. GC17002 γ1-MSH γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH Chemical Structure
  5. GC33693 β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)), a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist. β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) Chemical Structure
  6. GC34231 γ-1-Melanocyte Stimulating Hormone (MSH), amide γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure
  7. GC35244 ACTH (1-17) TFA ACTH (1-17) TFA Chemical Structure
  8. GC12239 ACTH (1-39) ACTH (1-39) is a melanocortin receptor agonist. ACTH (1-39) Chemical Structure
  9. GC66383 ACTH (11-24) (acetate) ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system. ACTH (11-24) (acetate) Chemical Structure
  10. GC31109 ACTH 1-17 (α1-17-ACTH) ACTH 1-17 (α1-17-ACTH), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. ACTH 1-17 (α1-17-ACTH) Chemical Structure
  11. GC31954 ACTH 11-24 (Adrenocorticotropic Hormone (11-24)) ACTH 11-24 (Adrenocorticotropic Hormone (11-24)) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH 11-24 (Adrenocorticotropic Hormone (11-24)) Chemical Structure
  12. GC35254 Adrenocorticotropic Hormone (ACTH) (1-39), rat Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist. Adrenocorticotropic Hormone (ACTH) (1-39), rat Chemical Structure
  13. GC35255 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 (MC2) receptor agonist. Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA Chemical Structure
  14. GC34002 Bremelanotide Acetate (PT-141 Acetate) Bremelanotide Acetate (PT-141 Acetate) (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction. Bremelanotide Acetate (PT-141 Acetate) Chemical Structure
  15. GC64525 Fenoprofen Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID). Fenoprofen Chemical Structure
  16. GC12840 HS 014 melanocortin MC4 receptor antagonist HS 014 Chemical Structure
  17. GC10747 HS 024 melanocortin MC4 receptor antagonist HS 024 Chemical Structure
  18. GC63724 HS014 TFA HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA Chemical Structure
  19. GC63770 HS024 TFA HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 TFA Chemical Structure
  20. GC10701 JKC 363 melanocortin MC4 receptor antagonist JKC 363 Chemical Structure
  21. GC30194 JNJ-10229570 JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 Chemical Structure
  22. GC13806 Lys-γ3-MSH Lys-γ3-MSH is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH Chemical Structure
  23. GC31629 MC-4R Agonist 1 MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R), used in the research of obesity, diabetes, and sexual dysfunction. MC-4R Agonist 1 Chemical Structure
  24. GC14127 MCL 0020 melanocortin MC4 receptor antagonist MCL 0020 Chemical Structure
  25. GC16276 Melanotan II Melanotan II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning. Melanotan II Chemical Structure
  26. GC64427 MK-0493 MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake. MK-0493 Chemical Structure
  27. GC13798 ML 00253764 hydrochloride melanocortin MC4 receptor antagonist ML 00253764 hydrochloride Chemical Structure
  28. GC50303 MSG 606

    MSG-606 has potent antagonist activity and receptor selectivity for the human melanocortin 1 receptor (hMC1R) (IC50 = 17 nM) .

     MSG 606 Chemical Structure
  29. GC36727 Neuropeptide EI, rat Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms. Neuropeptide EI, rat Chemical Structure
  30. GC36756 Nonapeptide-1 acetate salt Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt Chemical Structure
  31. GC32420 PF-00446687 PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12?±?1 nM. PF-00446687 Chemical Structure
  32. GC12163 PG 106 hMC3 receptor antagonist PG 106 Chemical Structure
  33. GC17626 PG 931 melanocortin 4 (MC4) receptor agonist PG 931 Chemical Structure
  34. GC63756 PG106 TFA PG106 TFA is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50= 210 nM) and has noactivity at?hMC4?receptors (EC50=9900 nM) and?hMC5?receptor. PG106 TFA Chemical Structure
  35. GC69813 Resomelagon

    Resomelagon (AP1189) is an orally effective melanocortin receptor (MR) agonist, including MC1 and MC3. Resomelagon induces phosphorylation of ERK1/2 and Ca2+ flow. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research.

     Resomelagon Chemical Structure
  36. GC69814 Resomelagon acetate

    Resomelagon (AP1189) acetate is an orally effective melanocortin receptor (MR) agonist, including MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca2+ flux. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research.

     Resomelagon acetate Chemical Structure
  37. GC37629 Setmelanotide TFA Setmelanotide TFA Chemical Structure
  38. GC13565 SHU 9119 melanocortin MC3 and MC4 receptor antagonist SHU 9119 Chemical Structure
  39. GC31600 SNT-207707 SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. SNT-207707 Chemical Structure
  40. GC31560 SNT-207858 SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT-207858 Chemical Structure
  41. GC38107 SNT-207858 free base SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT-207858 free base Chemical Structure
  42. GC18458 Terrein Terrein is a fungal metabolite produced by A. Terrein Chemical Structure
  43. GC16069 THIQ melanocortin 4 (MC4) receptor agonist THIQ Chemical Structure
  44. GC10947 [D-Trp8]-γ-MSH [D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH Chemical Structure
  45. GC13068 [Nle4,D-Phe7]-α-MSH [Nle4,D-Phe7]-α-MSH is a potent non-selective melanocortin receptor (MCR) agonist. [Nle4,D-Phe7]-α-MSH is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. [Nle4,D-Phe7]-α-MSH can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. [Nle4,D-Phe7]-α-MSH can be used for sunlight-induced skin cancers research. [Nle4,D-Phe7]-α-MSH Chemical Structure
  46. GC14374 α-MSH Alpha-melanocyte stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties. α-MSH Chemical Structure

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