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Home >> Signaling Pathways >> GPCR/G protein >> Melatonin Receptors

Melatonin Receptors

Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.

Products for  Melatonin Receptors

  1. Cat.No. Product Name Information
  2. GC14690 2-Iodomelatonin melatonin agonist 2-Iodomelatonin Chemical Structure
  3. GC11288 2-Phenylmelatonin

    N-acetyl-5methoxy-2phenyl Tryptamine

     2-Phenylmelatonin is a high affinity melatonin (MT) membrane receptor agonist. 2-Phenylmelatonin Chemical Structure
  4. GC16186 4-P-PDOT

    AH 024

    Melatonin receptor antagonist

     4-P-PDOT Chemical Structure
  5. GC12014 6-Chloromelatonin

    melatonin agonist

     6-Chloromelatonin Chemical Structure
  6. GC16020 8-M-PDOT

    AH 002

     Melatonin receptor agonist 8-M-PDOT Chemical Structure
  7. GC62825 ACH-000143 ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively. ACH-000143 Chemical Structure
  8. GC17981 Agomelatine

    S20098

     Agomelatine is a melatonin (MT) receptor agonist with Ki values of 0.1 nM and 0.12 nM for MT1 and MT2, respectively. Agomelatine is also a 5-hydroxytryptamine (5-HT) receptor antagonist with Ki values of 631 nM and 660 nM for 5-HT2C and 5-HT2B respectively. Agomelatine Chemical Structure
  9. GC35269 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride Chemical Structure
  10. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid Chemical Structure
  11. GC14728 DH 97 MT2 melatonin receptor antagonist DH 97 Chemical Structure
  12. GC11188 GR 135531

    5-METHOXYCARBONYLAMINO-N-ACETYLTRYPTAMINE

     MT3 receptor agonist GR 135531 Chemical Structure
  13. GC17898 Luzindole

    N-0774

    Melatonin antagonist

     Luzindole Chemical Structure
  14. GC15618 Melatonin

    NSC 56423, NSC 113928, Regulin

    Melatonin receptors agonist

     Melatonin Chemical Structure
  15. GC60241 Melatonin D5 An internal standard for the quantification of melatonin Melatonin D5 Chemical Structure
  16. GC69448 Melatonin-d3

    N-Acetyl-5-methoxytryptamine-d3

    Melatonin-d3 is the deuterated form of melatonin. Melatonin is a hormone produced by the pineal gland that activates melatonin receptors. It plays a role in sleep and has important antioxidant and anti-inflammatory properties. Melatonin is a novel selective ATF-6 inhibitor that induces apoptosis in human liver cancer cells through COX-2 downregulation. Melatonin also reduces palmitic acid-induced mouse granule cell apoptosis by attenuating endoplasmic reticulum stress.

     Melatonin-d3 Chemical Structure
  17. GC15365 N-Acetylserotonin

    N-Acetyl-5-hydroxytryptamine,NAS

     N-Acetylserotonin is a Melatonin precursor, and that it can potently activate TrkB receptor. N-Acetylserotonin Chemical Structure
  18. GC13047 N-Acetyltryptamine melatonin receptor modulator N-Acetyltryptamine Chemical Structure
  19. GC15053 Ramelteon

    TAK-375

     Agonist of melatonin receptor(M1-M2),highly selective Ramelteon Chemical Structure
  20. GC37070 Ramelteon metabolite M-II A mixed isomer preparation of ramelteon metabolite M-II Ramelteon metabolite M-II Chemical Structure
  21. GC68331 Ramelteon metabolite M-II-d3 Ramelteon metabolite M-II-d3 Chemical Structure
  22. GC64204 S-22153 S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 Chemical Structure
  23. GC38844 S26131 S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 Chemical Structure
  24. GC30781 Tasimelteon (BMS-214778)

    BMS 214778

     Tasimelteon (BMS-214778) (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon (BMS-214778) Chemical Structure

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