Oxytocin Receptors

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Products for Oxytocin Receptors

Cat.No. Product Name Information
GC12194 Atosiban

RW22164; RWJ22164

mixed antagonist of oxytocin and vasopressin receptors
GC39849 Atosiban acetate Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue.
GC11419 Carbetocin oxytocin receptor agonist
GC30594 Epelsiban (GSK 557296)

GSK 557296
Epelsiban (GSK 557296) (GSK 557296) is a potent, selective and orally bioavailable oxytocin receptor antagonist, with a pKi of 9.9 for human oxytocin receptor.
GC16620 L-368,899 hydrochloride L-368,899 hydrochloride is an orally active and selective OT (oxytocin ) receptor antagonist, with IC50s of 8.9 and 26 nM for uterus of rat and human, respectively.
GC11991 L-371,257 human oxytocin (OT) receptor antagonist
GC63036 L-372662 L-372662 is a potent and orally active non-peptide oxytocin antagonist with a Ki value of 4.8.
GC38922 LIT-001 LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).
GC32425 OT antagonist 1 OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
GC34364 OT antagonist 1 demethyl derivative OT antagonist 1 demethyl derivative is the demethyl derivative of OT antagonist 1.
GC32431 OT antagonist 3 OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.
GC36823 OT-R antagonist 1

Oxytocin receptor antagonist 1
OT-R antagonist 1 is a new potent and selective nonpeptide low molecular weight OT-R antagonist.
GC33540 OT-R antagonist 2 (Oxytocin receptor antagonist 2)

Oxytocin receptor antagonist 2
OT-R antagonist 2 (Oxytocin receptor antagonist 2) is a nonpeptide low molecular weight OT-R antagonist.
GC16222 Oxytocin Oxytocin is a pleiotropic hypothalamic peptide that helps in childbirth, lactation and prosocial behavior.
GC44526 Oxytocin (acetate)

Oxt

Oxytocin is a nonapeptide hormone primarily synthesized in magnocellular neurons of the paraventricular and supraoptic nuclei of the hypothalamus.
GC17249 PF-3274167 Oral oxytocin antagonist
GC31068 Retosiban (GSK 221149)

GSK 221149; GSK 221149A
Retosiban (GSK 221149) (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.
GC37635 SHR1653 SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR.
GC14001 TC OT 39 oxytocin receptor partial agonist
GC74398 Vasopressin Dimer (parallel) (TFA) Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin.
GC11042 WAY 267464 dihydrochloride WAY 267464 dihydrochloride is a non-peptide oxytocin receptor (OTR) agonist.
GC68698 [Asp5]-Oxytocin
[Asp5]-Oxytocin is a highly potent 5-position-neurohypophysial hormone analog. It can induce uterine contractions in vitro in rats and can be enhanced by magnesium ions. [Asp5]-Oxytocin has the ability to act as a rat uterotonic, avian vasopressin inhibitor, and rat antidiuretic agent.