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Home >> Signaling Pathways >> GPCR/G protein >> TSH Receptor

TSH Receptor

The thyrotropin receptor (TSHR), one of the primary antigens in autoimmune thyroid disease, is a target of both antigen-specific T cells and antibodies in patients with this condition. Autoantibodies to the TSHR (TSHR-Ab) act as thyroid stimulating factor (TSH) agonists in autoimmune hyperthyroidism (Robert Graves disease) but as TSH antagonists in autoimmune hypothyroidism (Hashimoto thyroiditis). The TSHR antigen is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been reported in a variety of cell types, some of which show evidence of receptor activity.

TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment.

TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function.

Products for  TSH Receptor

  1. Cat.No. Product Name Information
  2. GC60737 D3-βArr D3-βArr Chemical Structure
  3. GC31490 ML-109 ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM. ML-109 Chemical Structure
  4. GC12956 ML224 selective TSHR inverse agonist ML224 Chemical Structure
  5. GC64079 NCGC00229600 NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 Chemical Structure
  6. GC19543 NCGC00379308 NCGC00379308 is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro. NCGC00379308 Chemical Structure
  7. GC32423 Org41841 Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Org41841 Chemical Structure
  8. GC26016 TSHR antagonist S37 TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR). TSHR antagonist S37 Chemical Structure
  9. GC62519 TSHR antagonist S37a TSHR antagonist S37a is a highly selective thyrotropin receptor (TSHR) antagonist, with potential for the treatment of Graves' orbitopathy. TSHR antagonist S37a Chemical Structure
  10. GC62506 TSHR antagonist S37b TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a. TSHR antagonist S37b Chemical Structure
  11. GC65946 VA-K-14 hydrochloride VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM). VA-K-14 hydrochloride Chemical Structure

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