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Home >> Signaling Pathways >> Immunology/Inflammation >> 5-Lipoxygenase

5-Lipoxygenase

5-lipoxygenase catalyzes oxidation of AA at the 5-position to yield 5-HpETE and is a current target for pharmaceutical intervention in a number of diseases such as asthma, atherosclerosis and several cancers.

Products for  5-Lipoxygenase

  1. Cat.No. Product Name Information
  2. GC13379 1-Naphthyl 3,5-dinitrobenzoate

    1-(3,5-Dinitrobenzoyloxy)naphthalene,1-Naphthalonol 3,5-dinitrobenzoate

     dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor 1-Naphthyl 3,5-dinitrobenzoate Chemical Structure
  3. GC10821 11-keto-β-Boswellic Acid

    11-oxo-β-Boswellic acid,KBA

     11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid Chemical Structure
  4. GC17951 2-TEDC 5-, 12-, and 15-lipoxygenase inhibitor 2-TEDC Chemical Structure
  5. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     3-acetyl-11-keto-β-Boswellic Acid (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. 3-acetyl-11-keto-β-Boswellic Acid Chemical Structure
  6. GC12232 BAY-X 1005

    BAY X 1005; DG-031

     BAY-X 1005 (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. BAY-X 1005 Chemical Structure
  7. GC14601 BW 755C dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways BW 755C Chemical Structure
  8. GC10709 BW-B 70C

    5-Lipoxygenase inhibitor,potent and selective

     BW-B 70C Chemical Structure
  9. GC10331 Ebselen Ebselen is a selenoorganic compound with glutathione peroxidase-like activity and is an anti-inflammatory and antioxidant agent. Ebselen is an inhibitor of inositol monophosphatase (IMPase) with an IC50 of 1.5μM. Ebselen Chemical Structure
  10. GC12159 HZ52 5-lipoxygenase inhibitor HZ52 Chemical Structure
  11. GC14751 Malotilate

    NKK-105

     Stimulates hepatocyte regeneration Malotilate Chemical Structure
  12. GC12277 MK 886

    L-663,536

     FLAP and PPARα inhibitor, inhibits leukotriene biosynthesis MK 886 Chemical Structure
  13. GC12205 PD 146176

    NSC 168807

     PD 146176 is one of the potent and selective inhibitors of reticulocyte 15-LOX-1. PD 146176 Chemical Structure
  14. GC16046 Piriprost (potassium salt)

    U-60257B

     5-lipoxygenase inhibitor Piriprost (potassium salt) Chemical Structure
  15. GC10451 U-73122 U-73122 is a potent and selective phospholipase C (PLC) inhibitor with an IC50 value of approximately 1-2.1µM. It also inhibits 5-lipoxygenase (5-LO). U-73122 Chemical Structure
  16. GC16014 Zileuton

    A 64077

    5-lipoxygenase (5-LOX) inhibitor, orally active

     Zileuton Chemical Structure
  17. GC14435 Zileuton sodium 5-lipoxygenase and leukotrienes inhibitor Zileuton sodium Chemical Structure
  18. GC15961 β-acetyl-Boswellic Acid

    ABA,3-O-acetyl-β-Boswellic acid,β-Boswellic acid acetate

     β-acetyl-Boswellic Acid is a boswellic acid isolated from Boswellia serrata gum resin. β-acetyl-Boswellic Acid Chemical Structure

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