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Home >> Signaling Pathways >> Immunology/Inflammation >> NF-κB

NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

Products for  NF-κB

  1. Cat.No. Product Name Information
  2. GC40266 (+)-Praeruptorin A (+)-Praeruptorin A is a coumarin derivative originally isolated from P. (+)-Praeruptorin A Chemical Structure
  3. GC40264 (+)-Valencene

    (+)-Valencene is a sesquiterpene that has been found in C.

     (+)-Valencene Chemical Structure
  4. GC32705 (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) Chemical Structure
  5. GC61564 (E/Z)-IT-603 (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 Chemical Structure
  6. GC13030 (R)-(-)-Ibuprofen Inhibitor of Cox-1 and Cox-2 (R)-(-)-Ibuprofen Chemical Structure
  7. GC69823 (R)-(-)-Ibuprofen-d3

    (R)-(-)-Ibuprofen-d3 is the deuterated form of (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, which has no effect on COX and can inhibit NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory properties and can be used in pain relief research.

     (R)-(-)-Ibuprofen-d3 Chemical Structure
  8. GC39321 (Rac)-Myrislignan (Rac)-Myrislignan is the racemate of Myrislignan. (Rac)-Myrislignan Chemical Structure
  9. GC10821 11-keto-β-Boswellic Acid 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid Chemical Structure
  10. GC40763 14-deoxy-11,12-didehydro Andrographolide 14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. 14-deoxy-11,12-didehydro Andrographolide Chemical Structure
  11. GC68044 2,4,6-Trihydroxybenzaldehyde 2,4,6-Trihydroxybenzaldehyde Chemical Structure
  12. GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. 2,5-Dihydroxyacetophenone Chemical Structure
  13. GC60467 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone? 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Chemical Structure
  14. GC42406 4'-hydroxy Chalcone 4'-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. 4'-hydroxy Chalcone Chemical Structure
  15. GC38663 4-Hydroxychalcone A chalcone metabolite with diverse biological activities 4-Hydroxychalcone Chemical Structure
  16. GC35143 4-O-Methyl honokiol A phenol with diverse biological activities 4-O-Methyl honokiol Chemical Structure
  17. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7 Chemical Structure
  18. GC35185 7,4'-Dihydroxyflavone 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone Chemical Structure
  19. GC35199 8-Deoxygartanin 8-Deoxygartanin, a prenylated xanthones from G. 8-Deoxygartanin Chemical Structure
  20. GN10212 8-O-Acetyl shanzhiside methyl ester 8-O-Acetyl shanzhiside methyl ester Chemical Structure
  21. GC15598 Ac2-26 inhibitor of leukocyte extravasation Ac2-26 Chemical Structure
  22. GC35224 Ac2-26 TFA Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 TFA Chemical Structure
  23. GN10536 Aconine Aconine Chemical Structure
  24. GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol Chemical Structure
  25. GC67968 ALPK1-IN-2 ALPK1-IN-2 Chemical Structure
  26. GC39254 Anatabine dicitrate Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate Chemical Structure
  27. GN10718 Andrographolide Andrographolide Chemical Structure
  28. GC35340 Andropanolide Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. Andropanolide Chemical Structure
  29. GN10685 Anemarsaponin B Anemarsaponin B Chemical Structure
  30. GN10579 Aristolochic Acid A Aristolochic Acid A Chemical Structure
  31. GC35394 Armepavine Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine Chemical Structure
  32. GC35401 Asatone Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways. Asatone Chemical Structure
  33. GC35412 Asperulosidic Acid Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid Chemical Structure
  34. GN10415 Astilbin Astilbin Chemical Structure
  35. GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Avenanthramide-C methyl ester Chemical Structure
  36. GC39280 B022 B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki of 4.2 nM; IC50=15.1 nM). B022 Chemical Structure
  37. GN10018 Baicalin

    A flavonoid with diverse biological activities

     Baicalin Chemical Structure
  38. GC10345 Bay 11-7085

    NK-κB activation inhibitor

     Bay 11-7085 Chemical Structure
  39. GC13035 Bay 11-7821

    A selective and irreversible NF-κB inhibitor

     Bay 11-7821 Chemical Structure
  40. GC35494 Benzoyloxypaeoniflorin Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM. Benzoyloxypaeoniflorin Chemical Structure
  41. GN10443 Berbamine Berbamine Chemical Structure
  42. GN10358 Berbamine hydrochloride Berbamine hydrochloride Chemical Structure
  43. GC10480 Betulinic acid A plant triterpenoid similar to bile acids Betulinic acid Chemical Structure
  44. GC65010 Bortezomib-d8 Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity. Bortezomib-d8 Chemical Structure
  45. GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee. Cafestol Chemical Structure
  46. GC10692 Caffeic Acid Phenethyl Ester NF-κB activation inhibitor Caffeic Acid Phenethyl Ester Chemical Structure
  47. GC18069 Cardamonin Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. Cardamonin Chemical Structure
  48. GC43165 CAY10512 The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. CAY10512 Chemical Structure
  49. GC41601 CAY10591 CAY10591 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. CAY10591 Chemical Structure
  50. GC43190 CAY10682 (±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 Chemical Structure
  51. GC15394 CBL0137 (hydrochloride)

    curaxin that activates p53 and inhibits NF-κB

     CBL0137 (hydrochloride) Chemical Structure
  52. GC35629 CDDO-dhTFEA CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA Chemical Structure
  53. GC52081 Chamazulene

    Chamazulene is a terpene that has been found in chamomile (M. recutita) flowers and has anti-inflammatory and antioxidant activities.

     Chamazulene Chemical Structure
  54. GC31886 Chelidonic acid A pyran with diverse biological activities Chelidonic acid Chemical Structure
  55. GC12532 CHPG mGlu5 metabotropic glutamate receptor agonist CHPG Chemical Structure
  56. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt Chemical Structure
  57. GC17873 CID-2858522 A selective inhibitor of NF-κB activation CID-2858522 Chemical Structure
  58. GC39701 Convallatoxin Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin Chemical Structure
  59. GN10409 cor-nuside cor-nuside Chemical Structure
  60. GC38031 CORM-3 CORM-3 Chemical Structure
  61. GN10442 Curculigoside Curculigoside Chemical Structure
  62. GC30806 Cyclo(his-pro) (Cyclo(histidyl-proline)) Cyclo(his-pro) (Cyclo(histidyl-proline)) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) (Cyclo(histidyl-proline)) Chemical Structure
  63. GC38761 Cyclo(his-pro) TFA Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA Chemical Structure
  64. GN10178 Cyclohexanecarboxylicacid Cyclohexanecarboxylicacid Chemical Structure
  65. GC33330 Cynaropicrin A sesquiterpene lactone Cynaropicrin Chemical Structure
  66. GC38182 Dauricine Dauricine Chemical Structure
  67. GC38184 Dehydrodiisoeugenol Dehydrodiisoeugenol Chemical Structure
  68. GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine Chemical Structure
  69. GC38101 Demethyleneberberine Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity. Demethyleneberberine Chemical Structure
  70. GC34556 Dendrophenol Dendrophenol (Moscatilin) acts as a NF-κB inhibitor. Antineoplastic activity. Dendrophenol Chemical Structure
  71. GC60129 Deoxyelephantopin Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling. Deoxyelephantopin Chemical Structure
  72. GC33150 DHMEQ racemate (rel-DHMEQ) DHMEQ racemate (rel-DHMEQ) is a NF-κB inhibitor. DHMEQ racemate (rel-DHMEQ) is less active than (-)-DHMEQ. DHMEQ racemate (rel-DHMEQ) Chemical Structure
  73. GN10056 Dihydroartemisinin Dihydroartemisinin Chemical Structure
  74. GC52194 Dimethylamino Parthenolide Dimethylamino Parthenolide Chemical Structure
  75. GC43498 DL-α-Lipoic Acid DL-α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. DL-α-Lipoic Acid Chemical Structure
  76. GC34901 DMAPT A water-soluble parthenolide analog DMAPT Chemical Structure
  77. GC31557 Edasalonexent (CAT-1004) Edasalonexent (CAT-1004) (CAT-1004) is an orally bioavailable NF-κB inhibitor. Edasalonexent (CAT-1004) Chemical Structure
  78. GC16044 Emodin Natural CK2 inhibitor and ER agonist Emodin Chemical Structure
  79. GN10646 Engeletin Engeletin Chemical Structure
  80. GC43611 Enniatin B1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Enniatin B1 Chemical Structure
  81. GC18046 Erdosteine mucolytic Erdosteine Chemical Structure
  82. GC38637 Ergolide Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide Chemical Structure
  83. GC36006 Esculentoside H Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Esculentoside H Chemical Structure
  84. GN10004 EsculentosideA EsculentosideA Chemical Structure
  85. GC10519 Ethacrynic acid - d5 Used as an internal standard for GC- or LC-mass spectrometry Ethacrynic acid - d5 Chemical Structure
  86. GC38678 Ethyl Caffeate Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl Caffeate Chemical Structure
  87. GC38548 Eurycomalactone Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone Chemical Structure
  88. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin Fisetin-d5 Chemical Structure
  89. GC33717 Flaconitine (Acetylaconitine) Flaconitine (Acetylaconitine) is considered to be a NF-κB inhibitor. Flaconitine (Acetylaconitine) Chemical Structure
  90. GN10727 Forsythoside B Forsythoside B Chemical Structure
  91. GC39382 FW1256 FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 Chemical Structure
  92. GC64663 Galloylpaeoniflorin Galloylpaeoniflorin is a NF-κB inhibitor. Galloylpaeoniflorin Chemical Structure
  93. GN10156 Ginsenoside Rb1 Ginsenoside Rb1 Chemical Structure
  94. GN10220 Ginsenoside Rb3 Ginsenoside Rb3 Chemical Structure
  95. GN10549 Ginsenoside Rd Ginsenoside Rd Chemical Structure
  96. GN10307 Ginsenoside Re Ginsenoside Re Chemical Structure
  97. GN10544 Ginsenoside Rg1

    Ginsenoside Rg1 is one of the main active ingredients of ginseng and a steroidal glycoside with various biological activities. Ginsenoside Rg1 reduces brain Aβ levels and reduces NF-κB nuclear translocation.

     Ginsenoside Rg1 Chemical Structure
  98. GN10614 Ginsenoside Rg2 Ginsenoside Rg2 Chemical Structure
  99. GN10799 Ginsenoside Rg3 Ginsenoside Rg3 Chemical Structure
  100. GC31706 Ginsenoside Rg5 A ginsenoside with diverse biological activities Ginsenoside Rg5 Chemical Structure
  101. GN10019 Ginsenoside Rg6 Ginsenoside Rg6 Chemical Structure

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