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Home >> Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

NOD-like Receptor (NLR)

Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

Targets for  NOD-like Receptor (NLR)

Products for  NOD-like Receptor (NLR)

  1. Cat.No. Product Name Information
  2. GC50569 NLRP3-IN-2

    NLRP3 inflammasome inhibitor

     NLRP3-IN-2 Chemical Structure
  3. GC70787 β-Aminoarteether β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether Chemical Structure
  4. GC71405 ADS032 ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 Chemical Structure
  5. GC72081 Antcin A Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A Chemical Structure
  6. GC35385 Arglabin A sesquiterpene lactone Arglabin Chemical Structure
  7. GC62507 BMS-986299 BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. BMS-986299 Chemical Structure
  8. GC38059 Cardamonin A chalconoid with anti-inflammatory and anti-tumor activity Cardamonin Chemical Structure
  9. GC50342 CP 424174 Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3 CP 424174 Chemical Structure
  10. GC73796 CVN293 CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 Chemical Structure
  11. GC19113 CY-09 CY-09, a specific inhibitor of the NLRP3 inflammasome, directly targets NLRP3 and has an IC50 value of 18.9, 8.18, >50, >50 and 26.0 uM for each of the five major cytochrome P450 enzymes. CY-09 Chemical Structure
  12. GC34555 Dapansutrile

    3-methanesulfonyl Propanenitrile

     An NLRP3 inflammasome inhibitor Dapansutrile Chemical Structure
  13. GC69156 GDC-2394

    GDC-2394 is an orally effective and selective NLRP3 inhibitor that also inhibits IL-1β, with IC50 values of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits caspase-1 activity induced by NLRP3, but does not inhibit inflammasome activation dependent on NLRC4.

     GDC-2394 Chemical Structure
  14. GC60887 GSK717 GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 Chemical Structure
  15. GC71351 HMGB1-IN-1 HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC50 value of 15.9 ± 0.6 μM. HMGB1-IN-1 Chemical Structure
  16. GC74070 INF 195 INF 195 is an NLRP3 inhibitor. INF 195 Chemical Structure
  17. GC19201 INF39 INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. INF39 Chemical Structure
  18. GC60958 JC-171 JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages. JC-171 Chemical Structure
  19. GC62300 JC124 JC124 is a specific NLRP3 inflammasome inhibitor. JC124 Chemical Structure
  20. GC69311 JC2-11

    JC2-11 is an inhibitor of inflammasomes. It inhibits the NLRP3, AIM2, and non-canonical (NC) inflammasomes that contain a recruitment domain protein. JC2-11 reduces the secretion of caspase-1 (p20), cleavage of gasdermin D (GSDMD), and release of IL-1β and lactate dehydrogenase (LDH) in inflammasomes. JC2-11 inhibits the activation of inflammasomes by disrupting the production of reactive oxygen species and the activity of caspase-1.

     JC2-11 Chemical Structure
  21. GC72284 M-TriDAP M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1/2 agoist and biological active peptide. M-TriDAP Chemical Structure
  22. GC62454 MCC7840 sodium

    MCC7840 sodium

     Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium Chemical Structure
  23. GC31644 MCC950 (CP-456773)

    CP 456,773

     MCC950 (CP-456773) (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 (CP-456773) Chemical Structure
  24. GC10634 MCC950 sodium

    CRID3 sodium salt

    MCC950 is a potent, selective, small molecule inhibitor of NLRP3.

     MCC950 sodium Chemical Structure
  25. GC16641 ML130 (Nodinitib-1)

    CID1088438, ML130

     ML130 (Nodinitib-1) (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM. ML130 (Nodinitib-1) Chemical Structure
  26. GC50556 NBC 19 Potent NLRP3 inflammasome inhibitor NBC 19 Chemical Structure
  27. GC50611 NBC 6 NBC 6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NBC 6 Chemical Structure
  28. GC71149 NIC-0102 NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 Chemical Structure
  29. GC39719 Nigericin

    K+/H+ ionophore,promoting K+/H+ exchange across mitochondrial membrane

     Nigericin Chemical Structure
  30. GC15811 Nigericin sodium salt

    NSC 292567

     Nigericin sodium salt is an electrically neutral K +/H + ionophore from Streptomyctus hygroscopicus an antibiotic that is lipophilic and selectively causes potassium to drain from the mitochondrial membrane. Nigericin sodium salt Chemical Structure
  31. GC69570 NLRP3-IN-10

    NLRP3-IN-10 is a potent inhibitor of NLRP3 that inhibits IL-1β with an IC50 of 251.1 nM. NLRP3-IN-10 can reduce ASC speck formation and inhibit NLRP3 inflammasome activation.

     NLRP3-IN-10 Chemical Structure
  32. GC69571 NLRP3-IN-11

    NLRP3-IN-11 is an inhibitor of the NLRP3 protein. It has biological activity with an IC50 value of <0.3 μM. NLRP3-IN-11 can be used for research on inflammatory and degenerative diseases, including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout and many other autoimmune inflammatory diseases.

     NLRP3-IN-11 Chemical Structure
  33. GC69572 NLRP3-IN-13

    NLRP3-IN-13 (compound C77 in reference patent) is an effective selective NLRP3 inhibitor (IC50: 2.1 μM). It inhibits NLRP3 and NLRC4 inflammasomes, and suppresses IL-1β production mediated by NLRP3. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. It can be used for research on neuroinflammatory diseases.

     NLRP3-IN-13 Chemical Structure
  34. GC71230 NLRP3-IN-17 NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 Chemical Structure
  35. GC69573 NLRP3-IN-18

    NLRP3-IN-18 (compound 13) is an effective NLRP3 inhibitor with an IC50 value of ≤ 1.0 µM[1].

     NLRP3-IN-18 Chemical Structure
  36. GC69569 NLRP3/AIM2-IN-2

    NLRP3/AIM2-IN-2 is a novel potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-dependent cell pyroptosis, with an IC50 value of 0.2392 ±0.0233μM.

     NLRP3/AIM2-IN-2 Chemical Structure
  37. GC31657 NOD-IN-1 An inhibitor of NOD1 and NOD2 NOD-IN-1 Chemical Structure
  38. GC65995 NOD2 antagonist 1 NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs. NOD2 antagonist 1 Chemical Structure
  39. GC71499 NP3-562 NP3-562 is a potent, orally active, tricyclic NLRP3 Inhibitor, with an IC50 of 214 nM. NP3-562 Chemical Structure
  40. GC73942 NT-0249 free base NT-0249 free base is an orally active NLRP3 inhibitor. NT-0249 free base Chemical Structure
  41. GC73644 NT-0796 NT-0796 is an orally active, selective and CNS-penetrant NLRP3 inflammasome inhibitor. NT-0796 Chemical Structure
  42. GC74298 Oxidized low density lipoprotein (Human)

    Human ox-LDL

    Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis.

     Oxidized low density lipoprotein (Human) Chemical Structure
  43. GC72139 Peptide5 TFA Peptide5 TFA, a connexin 43 mimetic peptide, reduces animals swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 TFA Chemical Structure
  44. GC63377 QS-21 QS-21 is an immune-stimulatory saponin that can be used as an effective vaccine adjuvant. QS-21 Chemical Structure
  45. GN10172 Ruscogenin Ruscogenin Chemical Structure
  46. GC64089 Selnoflast Selnoflast (example 6) is a NLRP3 inhibitor (extracted from patent WO2019008025). Selnoflast Chemical Structure
  47. GC61284 Soyasaponin II Soyasaponin II is a saponin with antiviral activity. Soyasaponin II Chemical Structure
  48. GC40928 Trimethylamine N-oxide

    TMAO

     Trimethylamine N-oxide (TMAO) is a product of the oxidation of TMA by flavin-containing mono-oxygenase 3 in the liver. Trimethylamine N-oxide Chemical Structure
  49. GC15933 Troxerutin

    Trihydroxyethylrutin, Vitamin P4

     flavonoid Troxerutin Chemical Structure
  50. GC71396 Usnoflast Usnoflast is a NLRP3 modulator, as well as a non-steroidal anti-inflammatory agent (NSAD). Usnoflast Chemical Structure
  51. GC39311 YQ128 YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 ?M. YQ128 Chemical Structure

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