Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

NOD-like Receptor (NLR)

Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

Targets for  NOD-like Receptor (NLR)

Products for  NOD-like Receptor (NLR)

  1. Cat.No. Product Name Information
  2. GC50569 NLRP3-IN-2

    NLRP3 inflammasome inhibitor

     NLRP3-IN-2 Chemical Structure
  3. GC35385 Arglabin A sesquiterpene lactone Arglabin Chemical Structure
  4. GC62507 BMS-986299 BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. BMS-986299 Chemical Structure
  5. GC38059 Cardamonin A chalconoid with anti-inflammatory and anti-tumor activity Cardamonin Chemical Structure
  6. GC50342 CP 424174 Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3 CP 424174 Chemical Structure
  7. GC19113 CY-09

    CY-09, a specific inhibitor of the NLRP3 inflammasome, directly targets NLRP3 and has an IC50 value of 18.

     CY-09 Chemical Structure
  8. GC34555 Dapansutrile An NLRP3 inflammasome inhibitor Dapansutrile Chemical Structure
  9. GC60887 GSK717 GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 Chemical Structure
  10. GC19201 INF39 INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. INF39 Chemical Structure
  11. GC60958 JC-171 JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages. JC-171 Chemical Structure
  12. GC62300 JC124 JC124 is a specific NLRP3 inflammasome inhibitor. JC124 Chemical Structure
  13. GC62454 MCC7840 sodium Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium Chemical Structure
  14. GC31644 MCC950 (CP-456773) MCC950 (CP-456773) (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 (CP-456773) Chemical Structure
  15. GC10634 MCC950 sodium

    MCC950 is a potent, selective, small molecule inhibitor of NLRP3.

     MCC950 sodium Chemical Structure
  16. GC16641 ML130 (Nodinitib-1) ML130 (Nodinitib-1) (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM. ML130 (Nodinitib-1) Chemical Structure
  17. GC50556 NBC 19 Potent NLRP3 inflammasome inhibitor NBC 19 Chemical Structure
  18. GC50611 NBC 6 NBC 6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NBC 6 Chemical Structure
  19. GC39719 Nigericin

    K+/H+ ionophore,promoting K+/H+ exchange across mitochondrial membrane

     Nigericin Chemical Structure
  20. GC15811 Nigericin sodium salt

    Nigericin sodium salt is an electrically neutral K +/H +?ionophore from Streptomyctus hygroscopicus an antibiotic that is lipophilic and selectively causes potassium to drain from the mitochondrial membrane.

     Nigericin sodium salt Chemical Structure
  21. GC69570 NLRP3-IN-10

    NLRP3-IN-10 is a potent inhibitor of NLRP3 that inhibits IL-1β with an IC50 of 251.1 nM. NLRP3-IN-10 can reduce ASC speck formation and inhibit NLRP3 inflammasome activation.

     NLRP3-IN-10 Chemical Structure
  22. GC69571 NLRP3-IN-11

    NLRP3-IN-11 is an inhibitor of the NLRP3 protein. It has biological activity with an IC50 value of <0.3 μM. NLRP3-IN-11 can be used for research on inflammatory and degenerative diseases, including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout and many other autoimmune inflammatory diseases.

     NLRP3-IN-11 Chemical Structure
  23. GC69572 NLRP3-IN-13

    NLRP3-IN-13 (compound C77 in reference patent) is an effective selective NLRP3 inhibitor (IC50: 2.1 μM). It inhibits NLRP3 and NLRC4 inflammasomes, and suppresses IL-1β production mediated by NLRP3. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. It can be used for research on neuroinflammatory diseases.

     NLRP3-IN-13 Chemical Structure
  24. GC69573 NLRP3-IN-18

    NLRP3-IN-18 (compound 13) is an effective NLRP3 inhibitor with an IC50 value of ≤ 1.0 µM[1].

     NLRP3-IN-18 Chemical Structure
  25. GC69569 NLRP3/AIM2-IN-2

    NLRP3/AIM2-IN-2 is a novel potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-dependent cell pyroptosis, with an IC50 value of 0.2392 ±0.0233μM.

     NLRP3/AIM2-IN-2 Chemical Structure
  26. GC31657 NOD-IN-1 An inhibitor of NOD1 and NOD2 NOD-IN-1 Chemical Structure
  27. GC65995 NOD2 antagonist 1 NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs. NOD2 antagonist 1 Chemical Structure
  28. GC63377 QS-21

    QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant.

     QS-21 Chemical Structure
  29. GN10172 Ruscogenin Ruscogenin Chemical Structure
  30. GC64089 Selnoflast Selnoflast (example 6) is a NLRP3 inhibitor (extracted from patent WO2019008025). Selnoflast Chemical Structure
  31. GC61284 Soyasaponin II Soyasaponin II is a saponin with antiviral activity. Soyasaponin II Chemical Structure
  32. GC40928 Trimethylamine N-oxide Trimethylamine N-oxide (TMAO) is a product of the oxidation of TMA by flavin-containing mono-oxygenase 3 in the liver. Trimethylamine N-oxide Chemical Structure
  33. GC15933 Troxerutin flavonoid Troxerutin Chemical Structure
  34. GC39311 YQ128 YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 ?M. YQ128 Chemical Structure

33 Item(s)

per page

Set Descending Direction