CRAC Channel
The Ca2+ release-activated Ca2+ (CRAC) channel is a highly Ca2+-selective store-operated channel expressed in T cells, mast cells, and various other tissues. CRAC channels regulate critical cellular processes such as gene expression, motility, and the secretion of inflammatory mediators. The identification of Orai1, a key subunit of the CRAC channel pore, and STIM1, the endoplasmic reticulum (ER) Ca2+ sensor, have provided the tools to illuminate the mechanisms of regulation and the pore properties of CRAC channels. Opening of CRAC channels enables the refilling of ER Ca2+ stores and sustains long-lasting Ca2+ oscillations and plateau signals, critical for the proliferation of T cells and production of cytokines following antigenic stimulation.
Targets for CRAC Channel
Products for CRAC Channel
- Cat.No. Product Name Information
- GC50179 5J 4 CRAC channel blocker; anti-inflammatory
- GC19107 CM-4620 CM-4620 (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively.
- GC31852 CRAC intermediate 1 CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9.
- GC30361 CRAC intermediate 2 CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1.
- GC31680 GSK-5498A GSK-5498A is a selective CARC channel inhibitor (IC50: 1 μM).
- GC11683 MRS 1845 store-operated Ca2+ channels blocker
- GC65999 piCRAC-1 piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage.
- GC60327 RO2959 hydrochloride RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM.
- GC61248 RO2959 monohydrochloride RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM.
- GC37658 SOCE inhibitor 1 SOCE inhibitor 1 is a store-operated calcium entry (SOCE) inhibitor with an IC50 of 4.4 μM.
- GC33472 Synta66 Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease.
- GN10809 Tanshinone IIA sulfonate sodium
- GC14665 YM 58483 store-operated Ca2+ entry (SOCE) blocker