Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Targets for  iGluR

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC18033 γDGG γDGG is a competitive AMPA receptor blocker. γDGG  Chemical Structure
  3. GC61847 (R)-Lanicemine (R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine. (R)-Lanicemine  Chemical Structure
  4. GC61446 (Rac)-Lanicemine (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. (Rac)-Lanicemine  Chemical Structure
  5. GC60413 (Rac)-NMDAR antagonist 1 (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. (Rac)-NMDAR antagonist 1  Chemical Structure
  6. GC62746 (RS)-AMPA monohydrate (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate  Chemical Structure
  7. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist (S)-(-)-5-Fluorowillardiine  Chemical Structure
  8. GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist. (S)-(-)-5-Fluorowillardiine hydrochloride  Chemical Structure
  9. GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine) is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. (S)-Willardiine ((-)-Willardiine)  Chemical Structure
  10. GC12863 1-BCP potentiator of AMPA-mediated responses 1-BCP  Chemical Structure
  11. GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol  Chemical Structure
  12. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2. 6-Methoxy-2-naphthoic acid (Naproxen impurity O)  Chemical Structure
  13. GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist 7-Chlorokynurenic acid  Chemical Structure
  14. GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site 7-Chlorokynurenic acid sodium salt  Chemical Structure
  15. GC62840 AMPA receptor modulator-2 AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor. AMPA receptor modulator-2  Chemical Structure
  16. GC68438 AMPA receptor modulator-3 AMPA receptor modulator-3  Chemical Structure
  17. GC13164 Ampalex An AMPA receptor modulator Ampalex  Chemical Structure
  18. GC17695 Aniracetam Nootropic drug for senile dementia Aniracetam  Chemical Structure
  19. GC30911 Apimostinel (NRX-1074) Apimostinel (NRX-1074) (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist. Apimostinel (NRX-1074)  Chemical Structure
  20. GC38497 ATPA ATPA  Chemical Structure
  21. GC33723 Becampanel (AMP 397) Becampanel (AMP 397) (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. Becampanel (AMP 397)  Chemical Structure
  22. GC62874 BPAM344 BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM). BPAM344  Chemical Structure
  23. GC64574 BZAD-01 BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01  Chemical Structure
  24. GC61963 Caroverine hydrochloride Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride  Chemical Structure
  25. GC18079 CFM-2 AMPA antagonist CFM-2  Chemical Structure
  26. GC38493 CGP 37849 CGP 37849  Chemical Structure
  27. GC14414 CIQ NMDA receptor potentiator CIQ  Chemical Structure
  28. GC13290 CMPDA positive allosteric modulator of AMPA receptors CMPDA  Chemical Structure
  29. GC11799 CNQX AMPA/kainate receptor antagonist CNQX  Chemical Structure
  30. GC32553 CNS-5161 hydrochloride (CNS 5161A) CNS-5161 hydrochloride (CNS 5161A) is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. CNS-5161 hydrochloride (CNS 5161A)  Chemical Structure
  31. GC16899 Coluracetam Nootropic agent of the racetam family Coluracetam  Chemical Structure
  32. GC70055 Crocetin meglumine

    Crocetin (Transcrocetin) meglumine is extracted from saffron (Crocus sativus L.) and is a highly affinity NMDA receptor antagonist.

    Crocetin meglumine  Chemical Structure
  33. GC14495 CX 546 AMPA receptor potentiator CX 546  Chemical Structure
  34. GC64244 CX 717 CX 717 is a positive allosteric modulator of AMPA receptor. CX 717  Chemical Structure
  35. GC61751 Cycloleucine Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine  Chemical Structure
  36. GC16315 D-AP5

    A NMDA antagonist

    D-AP5  Chemical Structure
  37. GC25345 Deudextromethorphan (AVP-786) Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan (AVP-786)  Chemical Structure
  38. GC63881 DL-Phenylalanine-d5 hydrochloride DL-Phenylalanine-d5 hydrochloride  Chemical Structure
  39. GC32755 DNQX (FG 9041) DNQX (FG 9041) (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively). DNQX (FG 9041)  Chemical Structure
  40. GC35917 Dynorphin A (1-10) TFA Dynorphin A (1-10) TFA  Chemical Structure
  41. GC35918 Dynorphin A 1-10 Dynorphin A 1-10 an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A 1-10  Chemical Structure
  42. GC15343 Eliprodil NMDA receptor antagonist Eliprodil  Chemical Structure
  43. GC36027 Fanapanel hydrate Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Fanapanel hydrate  Chemical Structure
  44. GC18223 Farampator Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 uM for evoking glutamate currents in isolated pyramidal neurons. Farampator  Chemical Structure
  45. GC10522 Felbamate antagonist at the NMDA-associated glycine binding site Felbamate  Chemical Structure
  46. GC15363 Felbamate hydrate N-methyl-D-aspartate (NMDA) inhibitor Felbamate hydrate  Chemical Structure
  47. GC36060 Flupirtine Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupirtine  Chemical Structure
  48. GC11470 Flupirtine maleate NMDA receptor antagonist Flupirtine maleate  Chemical Structure
  49. GC64245 Glycine-13C2 Glycine-13C2  Chemical Structure
  50. GC64249 Glycine-15N Glycine-15N  Chemical Structure
  51. GC14121 GLYX 13 GLYX 13 (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. GLYX 13  Chemical Structure
  52. GC31270 GNE 0723 GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. GNE 0723  Chemical Structure
  53. GC31076 GNE 5729 GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. GNE 5729  Chemical Structure
  54. GC50433 GNE 9278 Positive allosteric modulator of NMDA receptors; acts in transmembrane domain GNE 9278  Chemical Structure
  55. GC31019 GV-196771A GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist. GV-196771A  Chemical Structure
  56. GC14842 GYKI 53655 hydrochloride AMPA and kainate receptor antagonist GYKI 53655 hydrochloride  Chemical Structure
  57. GA11338 H-D-Asp-OH An amino acid and a precursor in NMDA biosynthesis H-D-Asp-OH  Chemical Structure
  58. GA11306 H-D-Ser-OH An NMDA co-agonist H-D-Ser-OH  Chemical Structure
  59. GA10750 H-Glu-OH H-Glu-OH  Chemical Structure
  60. GA10922 H-Gly-OH H-Gly-OH  Chemical Structure
  61. GC11715 Ibotenic acid NMDA and metabotropic glutamate receptor agonist Ibotenic acid  Chemical Structure
  62. GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction IC87201  Chemical Structure
  63. GC12521 Ifenprodil Tartrate NMDA receptor antagonist Ifenprodil Tartrate  Chemical Structure
  64. GC39848 Indole-2-carboxylic acid Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid  Chemical Structure
  65. GC34638 JNJ-61432059 JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. JNJ-61432059  Chemical Structure
  66. GC36411 Kynurenic acid sodium Kynurenic acid sodium  Chemical Structure
  67. GC14810 L-701,324 NMDA receptor antagonist L-701,324  Chemical Structure
  68. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid monosodium salt (Monosodium glutamate)  Chemical Structure
  69. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N  Chemical Structure
  70. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid-d5  Chemical Structure
  71. GC66843 L-Homocysteic acid L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders. L-Homocysteic acid  Chemical Structure
  72. GC64148 L-Phenylalanine-15N L-Phenylalanine-15N  Chemical Structure
  73. GC65050 L-Phenylalanine-d2 L-Phenylalanine-d2  Chemical Structure
  74. GC63982 L-Phenylalanine-d5 L-Phenylalanine-d5  Chemical Structure
  75. GC64290 L-Phenylalanine-d8 L-Phenylalanine-d8  Chemical Structure
  76. GC11124 Lanicemine

    voltage-dependent NMDA channel blocker

    Lanicemine  Chemical Structure
  77. GC61842 Lanicemine dihydrochloride Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Lanicemine dihydrochloride  Chemical Structure
  78. GN10122 Linalool Linalool  Chemical Structure
  79. GC36510 LY3130481 LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM. LY3130481  Chemical Structure
  80. GC45776 LY404187 A positive allosteric modulator of AMPA receptors LY404187  Chemical Structure
  81. GC36515 LY450108 LY450108 is a potent AMPA receptor potentiator. LY450108  Chemical Structure
  82. GC13010 LY451395 LY451395 (LY451395) is a potent and highly selective potentiator of the AMPA receptors. LY451395  Chemical Structure
  83. GC30951 MDL 105519 MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor. MDL 105519  Chemical Structure
  84. GC14039 MDL-29951 Glycine antagonist of NMDA receptor activation MDL-29951  Chemical Structure
  85. GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment Meclofenoxate hydrochloride  Chemical Structure
  86. GC10198 Memantine hydrochloride NMDA receptor antagonist Memantine hydrochloride  Chemical Structure
  87. GC30973 Mephenesin Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant. Mephenesin  Chemical Structure
  88. GC31036 MRZ 2-514 MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM. MRZ 2-514  Chemical Structure
  89. GC63112 N-Methyl-DL-aspartic acid N-Methyl-DL-aspartic acid is a glutamate analogue and a?NMDA?receptor?agonist and can be used for neurological diseases research. N-Methyl-DL-aspartic acid  Chemical Structure
  90. GC33668 Naspm (1-Naphthylacetyl spermine) Naspm (1-Naphthylacetyl spermine) (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Naspm (1-Naphthylacetyl spermine)  Chemical Structure
  91. GC13349 Naspm trihydrochloride Ca2+-permeable AMPA receptor antagonist Naspm trihydrochloride  Chemical Structure
  92. GC14156 NBQX

    NBQX is a highly selective and competitive AMPA receptor antagonist.

    NBQX  Chemical Structure
  93. GC30860 Neu2000 Neu2000 (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Neu2000  Chemical Structure
  94. GC17456 NMDA (N-Methyl-D-aspartic acid) NMDA (N-Methyl-D-aspartic acid) is a specific agonist forNMDA (N-Methyl-D-aspartic acid)receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. NMDA (N-Methyl-D-aspartic acid)  Chemical Structure
  95. GC34352 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist. NMDAR antagonist 1  Chemical Structure
  96. GC64521 NMDAR/TRPM4-IN-2 free base NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base  Chemical Structure
  97. GC10270 Noopept An Analytical Reference Standard Noopept  Chemical Structure
  98. GC64133 NS-102 NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102  Chemical Structure
  99. GC33740 NT 13 (TPPT) NT 13 (TPPT) (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 (TPPT)  Chemical Structure
  100. GC30852 Org-26576 Org-26576 is a AMPA receptor positive allosteric modulator. Org-26576  Chemical Structure
  101. GC13779 Orphenadrine Citrate Antiparkinsonian and analgesic drug Orphenadrine Citrate  Chemical Structure

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