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iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC18033 γDGG glutamate receptor antagonist
  3. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist
  4. GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride
  5. GC30212 (S)-Willardiine ((-)-Willardiine)
  6. GC12863 1-BCP potentiator of AMPA-mediated responses
  7. GC33673 24-Hydroxycholesterol
  8. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O)
  9. GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist
  10. GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site
  11. GC13164 Ampalex Ampakine and nootropic
  12. GC17695 Aniracetam Nootropic drug for senile dementia
  13. GC30911 Apimostinel (NRX-1074)
  14. GC38497 ATPA
  15. GC33723 Becampanel (AMP 397)
  16. GC18079 CFM-2 AMPA antagonist
  17. GC38493 CGP 37849
  18. GC14414 CIQ NMDA receptor potentiator
  19. GC13290 CMPDA positive allosteric modulator of AMPA receptors
  20. GC11799 CNQX AMPA/kainate receptor antagonist
  21. GC32553 CNS-5161 hydrochloride (CNS 5161A)

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