iGluR
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
Targets for iGluR
Products for iGluR
- Cat.No. Product Name Information
- GC18033 γDGG γDGG is a competitive AMPA receptor blocker.
- GC61847 (R)-Lanicemine (R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine.
- GC61446 (Rac)-Lanicemine (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine.
- GC60413 (Rac)-NMDAR antagonist 1 (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1.
- GC62746 (RS)-AMPA monohydrate (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist.
- GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist
- GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist.
- GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine) is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM.
- GC12863 1-BCP potentiator of AMPA-mediated responses
- GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
- GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O) 6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2.
- GC10781 7-Chlorokynurenic acid NMDA receptor glycine site antagonist
- GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site
- GC62840 AMPA receptor modulator-2 AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor.
- GC68438 AMPA receptor modulator-3
- GC13164 Ampalex An AMPA receptor modulator
- GC17695 Aniracetam Nootropic drug for senile dementia
- GC30911 Apimostinel (NRX-1074) Apimostinel (NRX-1074) (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist.
- GC38497 ATPA
- GC33723 Becampanel (AMP 397) Becampanel (AMP 397) (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent.
- GC62874 BPAM344 BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM).
- GC64574 BZAD-01 BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM.
- GC61963 Caroverine hydrochloride Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor.
- GC18079 CFM-2 AMPA antagonist
- GC38493 CGP 37849
- GC14414 CIQ NMDA receptor potentiator
- GC13290 CMPDA positive allosteric modulator of AMPA receptors
- GC11799 CNQX AMPA/kainate receptor antagonist
- GC32553 CNS-5161 hydrochloride (CNS 5161A) CNS-5161 hydrochloride (CNS 5161A) is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
- GC16899 Coluracetam Nootropic agent of the racetam family
-
GC70055
Crocetin meglumine
Crocetin (Transcrocetin) meglumine is extracted from saffron (Crocus sativus L.) and is a highly affinity NMDA receptor antagonist.
- GC14495 CX 546 AMPA receptor potentiator
- GC64244 CX 717 CX 717 is a positive allosteric modulator of AMPA receptor.
- GC61751 Cycloleucine Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation.
-
GC16315
D-AP5
A NMDA antagonist
- GC25345 Deudextromethorphan (AVP-786) Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist.
- GC63881 DL-Phenylalanine-d5 hydrochloride
- GC32755 DNQX (FG 9041) DNQX (FG 9041) (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).
- GC35917 Dynorphin A (1-10) TFA
- GC35918 Dynorphin A 1-10 Dynorphin A 1-10 an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor.
- GC15343 Eliprodil NMDA receptor antagonist
- GC36027 Fanapanel hydrate Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
- GC18223 Farampator Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 uM for evoking glutamate currents in isolated pyramidal neurons.
- GC10522 Felbamate antagonist at the NMDA-associated glycine binding site
- GC15363 Felbamate hydrate N-methyl-D-aspartate (NMDA) inhibitor
- GC36060 Flupirtine Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
- GC11470 Flupirtine maleate NMDA receptor antagonist
- GC64245 Glycine-13C2
- GC64249 Glycine-15N
- GC14121 GLYX 13 GLYX 13 (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.
- GC31270 GNE 0723 GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively.
- GC31076 GNE 5729 GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
- GC50433 GNE 9278 Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
- GC31019 GV-196771A GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist.
- GC14842 GYKI 53655 hydrochloride AMPA and kainate receptor antagonist
- GA11338 H-D-Asp-OH An amino acid and a precursor in NMDA biosynthesis
- GA11306 H-D-Ser-OH An NMDA co-agonist
- GA10750 H-Glu-OH
- GA10922 H-Gly-OH
- GC11715 Ibotenic acid NMDA and metabotropic glutamate receptor agonist
- GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction
- GC12521 Ifenprodil Tartrate NMDA receptor antagonist
- GC39848 Indole-2-carboxylic acid Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation.
- GC34638 JNJ-61432059 JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8.
- GC36411 Kynurenic acid sodium
- GC14810 L-701,324 NMDA receptor antagonist
- GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
- GC64352 L-Glutamic acid-15N
- GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid.
- GC66843 L-Homocysteic acid L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders.
- GC64148 L-Phenylalanine-15N
- GC65050 L-Phenylalanine-d2
- GC63982 L-Phenylalanine-d5
- GC64290 L-Phenylalanine-d8
-
GC11124
Lanicemine
voltage-dependent NMDA channel blocker
- GC61842 Lanicemine dihydrochloride Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively).
- GN10122 Linalool
- GC36510 LY3130481 LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM.
- GC45776 LY404187 A positive allosteric modulator of AMPA receptors
- GC36515 LY450108 LY450108 is a potent AMPA receptor potentiator.
- GC13010 LY451395 LY451395 (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
- GC30951 MDL 105519 MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor.
- GC14039 MDL-29951 Glycine antagonist of NMDA receptor activation
- GC10443 Meclofenoxate hydrochloride Drug for senile dementia and AD treatment
- GC10198 Memantine hydrochloride NMDA receptor antagonist
- GC30973 Mephenesin Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.
- GC31036 MRZ 2-514 MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.
- GC63112 N-Methyl-DL-aspartic acid N-Methyl-DL-aspartic acid is a glutamate analogue and a?NMDA?receptor?agonist and can be used for neurological diseases research.
- GC33668 Naspm (1-Naphthylacetyl spermine) Naspm (1-Naphthylacetyl spermine) (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
- GC13349 Naspm trihydrochloride Ca2+-permeable AMPA receptor antagonist
-
GC14156
NBQX
NBQX is a highly selective and competitive AMPA receptor antagonist.
- GC30860 Neu2000 Neu2000 (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA).
- GC17456 NMDA (N-Methyl-D-aspartic acid) NMDA (N-Methyl-D-aspartic acid) is a specific agonist forNMDA (N-Methyl-D-aspartic acid)receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
- GC34352 NMDAR antagonist 1 NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist.
- GC64521 NMDAR/TRPM4-IN-2 free base NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor.
- GC10270 Noopept An Analytical Reference Standard
- GC64133 NS-102 NS-102 is a selective kainate (GluK2) receptor antagonist.
- GC33740 NT 13 (TPPT) NT 13 (TPPT) (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide.
- GC30852 Org-26576 Org-26576 is a AMPA receptor positive allosteric modulator.
- GC13779 Orphenadrine Citrate Antiparkinsonian and analgesic drug