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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Targets for  iGluR

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC18033 γDGG γDGG is a competitive AMPA receptor blocker. γDGG Chemical Structure
  3. GC61847 (R)-Lanicemine (R)-Lanicemine ((R)-AZD6765) is the less active R-enantiomer of Lanicemine. (R)-Lanicemine Chemical Structure
  4. GC61446 (Rac)-Lanicemine (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. (Rac)-Lanicemine Chemical Structure
  5. GC60413 (Rac)-NMDAR antagonist 1 (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. (Rac)-NMDAR antagonist 1 Chemical Structure
  6. GC62746 (RS)-AMPA monohydrate

    (±)-AMPA monohydrate

     (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate Chemical Structure
  7. GC11889 (S)-(-)-5-Fluorowillardiine AMPA receptor agonist (S)-(-)-5-Fluorowillardiine Chemical Structure
  8. GC34998 (S)-(-)-5-Fluorowillardiine hydrochloride

    (5S)-Fluorowillardiine hydrochloride; (S)-5-Fluorowillardiine hydrochloride

     (S)-(-)-5-Fluorowillardiine hydrochloride is a potent and specific AMPAR agonist. (S)-(-)-5-Fluorowillardiine hydrochloride Chemical Structure
  9. GC30212 (S)-Willardiine ((-)-Willardiine) (S)-Willardiine ((-)-Willardiine) is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. (S)-Willardiine ((-)-Willardiine) Chemical Structure
  10. GC12863 1-BCP

    Piperonylic acid piperidide

     potentiator of AMPA-mediated responses 1-BCP Chemical Structure
  11. GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol Chemical Structure
  12. GC70850 4′-Demethylnobiletin 4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling. 4′-Demethylnobiletin Chemical Structure
  13. GC31309 6-Methoxy-2-naphthoic acid (Naproxen impurity O)

    6-methoxy Naphthalene Acetic Acid, 6-methoxy-2-Naphthylacetic Acid, 6-MNA, NSC 408786

     6-Methoxy-2-naphthoic acid (Naproxen impurity O) is an NMDA receptor modulator extracted from patent WO 2012019106 A2. 6-Methoxy-2-naphthoic acid (Naproxen impurity O) Chemical Structure
  14. GC10781 7-Chlorokynurenic acid

    7-CKA, 7-CTKA, 7-chloro KYNA, NSC 149792

     NMDA receptor glycine site antagonist 7-Chlorokynurenic acid Chemical Structure
  15. GC11395 7-Chlorokynurenic acid sodium salt NMDA receptor antagonist acting at the glycine site 7-Chlorokynurenic acid sodium salt Chemical Structure
  16. GC70946 AMPA receptor antagonist-3 AMPA receptor antagonist-3 is an AMPA receptor antagonist extracted from patent US20070027143A1. AMPA receptor antagonist-3 Chemical Structure
  17. GC70348 AMPA receptor modulator-1 AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9.7, more selective over GluA1/γ-2 (pIC50=5). AMPA receptor modulator-1 Chemical Structure
  18. GC62840 AMPA receptor modulator-2 AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor. AMPA receptor modulator-2 Chemical Structure
  19. GC68438 AMPA receptor modulator-3 AMPA receptor modulator-3 Chemical Structure
  20. GC13164 Ampalex

    Ampalex, BDP-12, Benzoyl-Piperidine-12

     An AMPA receptor modulator Ampalex Chemical Structure
  21. GC17695 Aniracetam

    Memodrin, Ro 13-5057, Sarpul

     Nootropic drug for senile dementia Aniracetam Chemical Structure
  22. GC30911 Apimostinel (NRX-1074)

    NRX-1074; AGN-241660

     Apimostinel (NRX-1074) (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist. Apimostinel (NRX-1074) Chemical Structure
  23. GC38497 ATPA ATPA Chemical Structure
  24. GC33723 Becampanel (AMP 397)

    AMP 397

     Becampanel (AMP 397) (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. Becampanel (AMP 397) Chemical Structure
  25. GC62874 BPAM344 BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM). BPAM344 Chemical Structure
  26. GC64574 BZAD-01 BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01 Chemical Structure
  27. GC61963 Caroverine hydrochloride

    Tinnex hydrochloride

     Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride Chemical Structure
  28. GC18079 CFM-2 AMPA antagonist CFM-2 Chemical Structure
  29. GC38493 CGP 37849 CGP 37849 Chemical Structure
  30. GC14414 CIQ NMDA receptor potentiator CIQ Chemical Structure
  31. GC13290 CMPDA positive allosteric modulator of AMPA receptors CMPDA Chemical Structure
  32. GC11799 CNQX

    6cyano7Nitroquinoxaline2,3dione, FG 9065

     CNQX is an effective competitive antagonist of AMPA/kainate receptors, with IC50 values of 0.3µM and 1.5µM, respectively[1]. CNQX Chemical Structure
  33. GC32553 CNS-5161 hydrochloride (CNS 5161A)

    CNS 5161A

     CNS-5161 hydrochloride (CNS 5161A) is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. CNS-5161 hydrochloride (CNS 5161A) Chemical Structure
  34. GC16899 Coluracetam

    BCI-540, MKC-231

     Nootropic agent of the racetam family Coluracetam Chemical Structure
  35. GC70055 Crocetin meglumine

    Transcrocetin meglumine; trans-Crocetin meglumine

    Crocetin (Transcrocetin) meglumine is extracted from saffron (Crocus sativus L.) and is a highly affinity NMDA receptor antagonist.

     Crocetin meglumine Chemical Structure
  36. GC14495 CX 546 AMPA receptor potentiator CX 546 Chemical Structure
  37. GC64244 CX 717 CX 717 is a positive allosteric modulator of AMPA receptor. CX 717 Chemical Structure
  38. GC61751 Cycloleucine Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation. Cycloleucine Chemical Structure
  39. GC16315 D-AP5

    D-2-Amino-5-Phosphonovaleric acid; D-APV

     D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist with a Kd value of 1.4μM. D-AP5 Chemical Structure
  40. GC70993 Dalzanemdor Dalzanemdor (SAGE-718) is a N-methyl-D-aspartate (NMDA) receptor positive allosteric modulator. Dalzanemdor Chemical Structure
  41. GC68954 Decanoic acid-d5

    Decanoic acid-d5 is the deuterated form of Decanoic acid. Decanoic acid is a component of medium-chain triglycerides and is a non-competitive inhibitor of AMPA receptors that can penetrate the blood-brain barrier. Decanoic acid has anticonvulsant properties.

     Decanoic acid-d5 Chemical Structure
  42. GC25345 Deudextromethorphan (AVP-786) Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist. Deudextromethorphan (AVP-786) Chemical Structure
  43. GC63881 DL-Phenylalanine-d5 hydrochloride

    2-Amino-3-phenylpropionic acid-d5 hydrochloride

     DL-Phenylalanine-d5 hydrochloride Chemical Structure
  44. GC32755 DNQX (FG 9041)

    6,7Dinitroquinoxaline2,3dione, FG 9041

     DNQX (FG 9041) (FG 9041), a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively). DNQX (FG 9041) Chemical Structure
  45. GC35917 Dynorphin A (1-10) TFA Dynorphin A (1-10) TFA Chemical Structure
  46. GC35918 Dynorphin A 1-10 Dynorphin A 1-10 an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A 1-10 Chemical Structure
  47. GC15343 Eliprodil

    SL 820715

     NMDA receptor antagonist Eliprodil Chemical Structure
  48. GC36027 Fanapanel hydrate

    ZK200775 hydrate; MPQX hydrate

     Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. Fanapanel hydrate Chemical Structure
  49. GC18223 Farampator

    CX-691

     Farampator is a positive allosteric modulator of AMPA receptors that has an EC50 value greater than 32 uM for evoking glutamate currents in isolated pyramidal neurons. Farampator Chemical Structure
  50. GC10522 Felbamate

    ADD 03055

     antagonist at the NMDA-associated glycine binding site Felbamate Chemical Structure
  51. GC15363 Felbamate hydrate

    W-554 hydrate; ADD-03055 hydrate

     N-methyl-D-aspartate (NMDA) inhibitor Felbamate hydrate Chemical Structure
  52. GC69118 Fluoroethylnormemantine

    Fluoroethylnormemantine is a derivative of Memantine and an antagonist of N-methyl-D-aspartate (NMDA) receptors. [18F]-Fluoroethylnormemantine can be used as a tracer for positron emission tomography (PET). Fluoroethylnormemantine has anti-amnesic, neuroprotective, antidepressant-like, and fear-reducing effects.

     Fluoroethylnormemantine Chemical Structure
  53. GC69119 Fluoroethylnormemantine hydrochloride

    Fluoroethylnormemantine hydrochloride is a derivative of Memantine and an antagonist of N-methyl-D-aspartate (NMDA) receptors. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride has anti-amnesic, neuroprotective, antidepressant-like, and fear-reducing effects.

     Fluoroethylnormemantine hydrochloride Chemical Structure
  54. GC36060 Flupirtine Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupirtine Chemical Structure
  55. GC11470 Flupirtine maleate NMDA receptor antagonist Flupirtine maleate Chemical Structure
  56. GC69175 GluN2B-NMDAR antagonist-1

    GluN2B-NMDAR antagonist-1 is an orally active GluN2B-NMDAR antagonist. It has neuroprotective activity and can be used in research on ischemic injury.

     GluN2B-NMDAR antagonist-1 Chemical Structure
  57. GC64245 Glycine-13C2 Glycine-13C2 Chemical Structure
  58. GC64249 Glycine-15N Glycine-15N Chemical Structure
  59. GC14121 GLYX 13

    Rapastinel

     GLYX 13 (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. GLYX 13 Chemical Structure
  60. GC31270 GNE 0723 GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. GNE 0723 Chemical Structure
  61. GC31076 GNE 5729 GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. GNE 5729 Chemical Structure
  62. GC50433 GNE 9278 Positive allosteric modulator of NMDA receptors; acts in transmembrane domain GNE 9278 Chemical Structure
  63. GC31019 GV-196771A GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist. GV-196771A Chemical Structure
  64. GC14842 GYKI 53655 hydrochloride

    LY300168 hydrochloride

     AMPA and kainate receptor antagonist GYKI 53655 hydrochloride Chemical Structure
  65. GA11338 H-D-Asp-OH

    NSC 97922

     An amino acid and a precursor in NMDA biosynthesis H-D-Asp-OH Chemical Structure
  66. GA11306 H-D-Ser-OH

    NSC 77689, (R)-Serine

     An NMDA co-agonist H-D-Ser-OH Chemical Structure
  67. GA10750 H-Glu-OH H-Glu-OH Chemical Structure
  68. GA10922 H-Gly-OH H-Gly-OH Chemical Structure
  69. GC69208 HBT1

    HBT1 is an effective enhancer of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPA-R). HBT1 binds to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner, specifically at S518. HBT1 did not show significant bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons.

     HBT1 Chemical Structure
  70. GC11715 Ibotenic acid

    NSC 204850

     NMDA and metabotropic glutamate receptor agonist Ibotenic acid Chemical Structure
  71. GC30847 IC87201 An inhibitor of the nNOS-PSD-95 protein-protein interaction IC87201 Chemical Structure
  72. GC12521 Ifenprodil Tartrate NMDA receptor antagonist Ifenprodil Tartrate Chemical Structure
  73. GC39848 Indole-2-carboxylic acid Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid Chemical Structure
  74. GC34638 JNJ-61432059 JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. JNJ-61432059 Chemical Structure
  75. GC36411 Kynurenic acid sodium Kynurenic acid sodium Chemical Structure
  76. GC14810 L-701,324 NMDA receptor antagonist L-701,324 Chemical Structure
  77. GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate) L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid monosodium salt (Monosodium glutamate) Chemical Structure
  78. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N Chemical Structure
  79. GC65095 L-Glutamic acid-d5 L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid-d5 Chemical Structure
  80. GC66843 L-Homocysteic acid

    L-HCA

     L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders. L-Homocysteic acid Chemical Structure
  81. GC64148 L-Phenylalanine-15N L-Phenylalanine-15N Chemical Structure
  82. GC65050 L-Phenylalanine-d2 L-Phenylalanine-d2 Chemical Structure
  83. GC63982 L-Phenylalanine-d5 L-Phenylalanine-d5 Chemical Structure
  84. GC64290 L-Phenylalanine-d8 L-Phenylalanine-d8 Chemical Structure
  85. GC11124 Lanicemine

    AZD 6765,AR-R 15896AR

    voltage-dependent NMDA channel blocker

     Lanicemine Chemical Structure
  86. GC61842 Lanicemine dihydrochloride Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Lanicemine dihydrochloride Chemical Structure
  87. GN10122 Linalool

    dl-Linalool, NSC 3789

     Linalool Chemical Structure
  88. GC36510 LY3130481 LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM. LY3130481 Chemical Structure
  89. GC45776 LY404187 A positive allosteric modulator of AMPA receptors LY404187 Chemical Structure
  90. GC36515 LY450108 LY450108 is a potent AMPA receptor potentiator. LY450108 Chemical Structure
  91. GC13010 LY451395

    LY451395

     LY451395 (LY451395) is a potent and highly selective potentiator of the AMPA receptors. LY451395 Chemical Structure
  92. GC30951 MDL 105519 MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor. MDL 105519 Chemical Structure
  93. GC14039 MDL-29951 Glycine antagonist of NMDA receptor activation MDL-29951 Chemical Structure
  94. GC10443 Meclofenoxate hydrochloride

    Dimethylaminoethyl 4-chlorophenoxyacetate, Methocynal

     Drug for senile dementia and AD treatment Meclofenoxate hydrochloride Chemical Structure
  95. GC10198 Memantine hydrochloride

    Akatinol, Axura, Ebix, Namenda, NSC 102290, SUN Y7017

     NMDA receptor antagonist Memantine hydrochloride Chemical Structure
  96. GC30973 Mephenesin Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant. Mephenesin Chemical Structure
  97. GC31036 MRZ 2-514 MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM. MRZ 2-514 Chemical Structure
  98. GC63112 N-Methyl-DL-aspartic acid N-Methyl-DL-aspartic acid is a glutamate analogue and a?NMDA?receptor?agonist and can be used for neurological diseases research. N-Methyl-DL-aspartic acid Chemical Structure
  99. GC33668 Naspm (1-Naphthylacetyl spermine)

    1-Naphthylacetyl spermine

     Naspm (1-Naphthylacetyl spermine) (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Naspm (1-Naphthylacetyl spermine) Chemical Structure
  100. GC13349 Naspm trihydrochloride

    1-Naphthylacetyl spermine

     Ca2+-permeable AMPA receptor antagonist Naspm trihydrochloride Chemical Structure
  101. GC14156 NBQX NBQX is a highly selective and competitive AMPA receptor antagonist. NBQX Chemical Structure

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