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iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

Targets for  iGluR

Products for  iGluR

  1. Cat.No. Product Name Information
  2. GC33701 Orphenadrine hydrochloride A muscarinic acetylcholine receptor antagonist Orphenadrine hydrochloride  Chemical Structure
  3. GC16562 PEAQX NMDA antagonist PEAQX  Chemical Structure
  4. GC36865 PEAQX tetrasodium hydrate PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate  Chemical Structure
  5. GC13007 PEPA Novel allosteric potentiator of AMPA receptor desensitization PEPA  Chemical Structure
  6. GC36876 Perzinfotel Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel  Chemical Structure
  7. GC64929 Pesampator Pesampator (PF-04958242) is a potent and highly selective positive allosteric modulator of AMPA receptor (an AMPA potentiator) with an EC50 of 310 nM and a Ki of 170 nM. Pesampator  Chemical Structure
  8. GC14492 PF 4778574 positive allosteric modulator of AMPA receptors PF 4778574  Chemical Structure
  9. GC12703 Philanthotoxin 74 Philanthotoxin 74 (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Philanthotoxin 74  Chemical Structure
  10. GC13469 Piracetam cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA) Piracetam  Chemical Structure
  11. GC65954 Plazinemdor Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system.. Plazinemdor  Chemical Structure
  12. GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) Procyclidine (Tricyclamol, (±)-Procyclidine) hydrochloride , an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)  Chemical Structure
  13. GC16776 QNZ 46 NR2C/NR2D-selective NMDA receptor antagonist QNZ 46  Chemical Structure
  14. GC14547 Quinolinic acid NMDA agonist Quinolinic acid  Chemical Structure
  15. GC34753 Radiprodil

    An NMDA receptor antagonist

    Radiprodil  Chemical Structure
  16. GC33492 Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties. Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate)  Chemical Structure
  17. GC30835 Rislenemdaz (MK-0657) Rislenemdaz (MK-0657) (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively. Rislenemdaz (MK-0657)  Chemical Structure
  18. GC19310 Ro 25-6981 Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. Ro 25-6981  Chemical Structure
  19. GC18410 Ro 25-6981 (maleate) Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively). Ro 25-6981 (maleate)  Chemical Structure
  20. GC31039 RPR104632 RPR104632 is a specific antagonist of NMDA receptor, with potent neuroprotective properties. RPR104632  Chemical Structure
  21. GC13684 S 18986 positive allosteric modulator of AMPA receptors S 18986  Chemical Structure
  22. GC18118 SDZ 220-581 SDZ 220-581  Chemical Structure
  23. GC37612 SDZ 220-581 Ammonium salt SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7. SDZ 220-581 Ammonium salt  Chemical Structure
  24. GC16986 SDZ 220-581 hydrochloride NMDA receptor antagonist SDZ 220-581 hydrochloride  Chemical Structure
  25. GC61580 Sepimostat Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat  Chemical Structure
  26. GC61570 Sepimostat dimethanesulfonate Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate  Chemical Structure
  27. GC37703 Sunifiram Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam. Sunifiram  Chemical Structure
  28. GC16101 SYM 2081 kainate receptor agonist SYM 2081  Chemical Structure
  29. GC13728 SYM 2206 AMPA receptor antagonist SYM 2206  Chemical Structure
  30. GC64650 TAK-653 TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. TAK-653  Chemical Structure
  31. GC19346 Talampanel Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Talampanel  Chemical Structure
  32. GC30774 Tat-NR2B9c

    Tat-NR2B9c is designed to prevent nitric oxide (NO) production by preventing postsynaptic density protein 95 (PSD-95) binding to N-methyl-D-aspartate (NMDA) receptors and neuronal nitric oxide synthase.

    Tat-NR2B9c  Chemical Structure
  33. GC34828 Tat-NR2B9c TFA Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA  Chemical Structure
  34. GC60354 Tat-NR2Baa Tat-NR2BAA is the control peptide of Tat-NR2B9c, inactive. Tat-NR2Baa  Chemical Structure
  35. GC11585 TCN 237 dihydrochloride TCN 237 dihydrochloride is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. TCN 237 dihydrochloride  Chemical Structure
  36. GC16149 Topiramate An anticonvulsant Topiramate  Chemical Structure
  37. GC50198 Topiramate - d12 Deuterated topiramate Topiramate - d12  Chemical Structure
  38. GC33341 Transcrocetin (trans-Crocetin) Transcrocetin (trans-Crocetin) (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Transcrocetin (trans-Crocetin) (trans-Crocetin) is capable of crossing the blood-brain barrier and reach the central nervous system (CNS). Transcrocetin (trans-Crocetin)  Chemical Structure
  39. GC37821 Transcrocetin meglumine salt Transcrocetin meglumine salt, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Transcrocetin meglumine salt  Chemical Structure
  40. GC32447 Transcrocetinate disodium (Disodium trans-crocetinate) Transcrocetinate disodium (Disodium trans-crocetinate), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity. Transcrocetinate disodium (Disodium trans-crocetinate)  Chemical Structure
  41. GC30839 Traxoprodil

    An antagonist of NR2B subunit-containing NMDA receptors

    Traxoprodil  Chemical Structure
  42. GC33685 Tulrampator (CX-1632) Tulrampator (CX-1632) (CX-1632) is an orally bioavailable positive AMPAR (allosteric modulator of AMPA receptor). Tulrampator (CX-1632)  Chemical Structure
  43. GC38446 UBP 302 An antagonist of GluR5 subunit-containing kainate receptors UBP 302  Chemical Structure
  44. GC70084 UBP301 hydrochloride

    UBP301 hydrochloride is an effective selective antagonist of kainate receptors, with IC50 and KD values of 164 μM and 5.94 μM, respectively. UBP301 hydrochloride has a selectivity for kainate receptors over AMPA receptors that is 30 times higher. It is a derivative of Willardiine.

    UBP301 hydrochloride  Chemical Structure
  45. GC31153 UK-240455 UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. UK-240455  Chemical Structure
  46. GC67922 Zelquistinel Zelquistinel  Chemical Structure
  47. GC16300 ZK 200775 ZK 200775 (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. ZK 200775  Chemical Structure
  48. GC30818 ZL006 ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis. ZL006  Chemical Structure
  49. GC30457 Zonampanel (YM 872) Zonampanel (YM 872) (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor. Zonampanel (YM 872)  Chemical Structure

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