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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Monocarboxylate Transporters

Monocarboxylate Transporters

Monocarboxylate transporters (MCTs) constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such aslactate and pyruvate, across biological membranes. Highly malignant tumors rely heavily on aerobic glycolysis (metabolism of glucose to lactic acid even under ample tissue oxygen; Warburg Effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from being "pickled to death". The MCTs have been successfully targeted in pre-clinical studies using RNAi and a small-molecule inhibitor alpha-cyano-4-hydroxycinnamic acid (ACCA; CHC) to show that inhibiting lactic acid efflux is a very effective therapeutic strategy against highly glycolytic malignant tumors.

Products for  Monocarboxylate Transporters

  1. Cat.No. Product Name Information
  2. GC13691 7ACC1

    Coumarin D 1421, 7-DCCA, 7-Diethylamino-2-oxo-2H-chromen-3-carboxylic Acid

     MCT inhibitor 7ACC1 Chemical Structure
  3. GC14642 7ACC2 MCT inhibitor 7ACC2 Chemical Structure
  4. GC50226 AR-C 141990 hydrochloride MCT1 inhibitor AR-C 141990 hydrochloride Chemical Structure
  5. GC10680 AR-C155858 An inhibitor of MCT1 and 2 AR-C155858 Chemical Structure
  6. GC11010 AZD 3965 Ki = 1.6 nM for MCT1

    AZD 3965 is a potent inhibitor of monocarboxylate transporter 1 (MCT1). AZD 3965 Chemical Structure

  7. GC68713 AZD0095

    AZD0095 is a selective and orally active MCT4 inhibitor (IC50: 1.3 nM). When used in combination with Cediranib, AZD0095 effectively inhibits tumor growth of NCI-H358 xenografts.

     AZD0095 Chemical Structure
  8. GC19488 BAY-8002

    BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1)

     BAY-8002 Chemical Structure
  9. GC10877 CHC

    CHC, α-CHCA, NSC 173138

     CHC (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). CHC Chemical Structure
  10. GC73305 MCT-IN-1 MCT-IN-1 (compound 2) is a potent inhibitor of monocarboxylate transporter (MCT), with the IC50 of 9 nM and 14 nM for MCT1 and MCT4, respectively. MCT-IN-1 Chemical Structure
  11. GC63062 MCT4-IN-1

    MCT4-IN-1

     MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research. MCT4-IN-1 Chemical Structure
  12. GC50163 SR 13800 SR 13800 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. SR 13800 has anti-cancer activity. SR 13800 Chemical Structure
  13. GC63496 VB124 VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 Chemical Structure

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