Monocarboxylate Transporters

Monocarboxylate transporters (MCTs) constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such aslactate and pyruvate, across biological membranes. Highly malignant tumors rely heavily on aerobic glycolysis (metabolism of glucose to lactic acid even under ample tissue oxygen; Warburg Effect) and thus need to efflux lactic acid via MCTs to the tumor micro-environment to maintain a robust glycolytic flux and to prevent the tumor from being "pickled to death". The MCTs have been successfully targeted in pre-clinical studies using RNAi and a small-molecule inhibitor alpha-cyano-4-hydroxycinnamic acid (ACCA; CHC) to show that inhibiting lactic acid efflux is a very effective therapeutic strategy against highly glycolytic malignant tumors.

Products for Monocarboxylate Transporters

Cat.No. Product Name Information
GC13691 7ACC1 MCT inhibitor
GC14642 7ACC2 MCT inhibitor
GC50226 AR-C 141990 hydrochloride MCT1 inhibitor
GC10680 AR-C155858 An inhibitor of MCT1 and 2
GC11010 AZD 3965 potent inhibitor of monocarboxylate transporter 1 (MCT1)
GC19488 BAY-8002
BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1)
GC10877 CHC CHC (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs).
GC63062 MCT4-IN-1 MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research.
GC50163 SR 13800 SR 13800 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. SR 13800 has anti-cancer activity.
GC63496 VB124 VB124 is an orally active, potent, and selective MCT4 inhibitor.