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P-glycoprotein

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

Products for  P-glycoprotein

  1. Cat.No. Product Name Information
  2. GC30371 Alisol F
  3. GC12945 Atazanavir

    HIV protease inhibitor,highly potent

  4. GC10240 Atazanavir sulfate (BMS-232632-05)

    Protease inhibitor

  5. GC33338 Biricodar (VX-710)
  6. GC35892 Dofequidar
  7. GC13375 Dofequidar fumarate MDR reversal agent
  8. GC17215 Elacridar BCRP inhibitor
  9. GC17163 Elacridar hydrochloride BCRP and P-GP inhibitor
  10. GC31340 Encequidar (HM30181)
  11. GC33185 Encequidar mesylate (HM30181 (mesylate))
  12. GC10391 Hypophyllanthin P-glycoprotein (P-gp) inhibitor
  13. GC16609 LY335979 (Zosuquidar 3HCL) Pgp (P-glycoprotein) inhibitor
  14. GC33375 MCI826
  15. GC32518 Norverapamil hydrochloride ((±)-Norverapamil hydrochloride)
  16. GC18470 NSC 23925
  17. GN10020 Piperine MAPK inhibitor
  18. GC33151 Polyoxyethylene stearate (POES)
  19. GN10805 Protopanaxdiol Extracted from Panax ginseng C. A. Mey.;Suitability:Acetone,DMSO;Store the product in sealed,cool and dry condition
  20. GC12523 Reversan inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp)
  21. GC12986 Risperidone

    SR-2A inhibitor

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